Skip to main content

End-of-Life Decision Making in Older Patients with Acute Kidney Injury and End-Stage Renal Disease: Ethical Perspectives

  • Chapter
  • First Online:
Managing Renal Injury in the Elderly Patient

Abstract

End-of-life discussions with older patients facing the prospect of dialysis are challenging and require acknowledgement of and respect for ethical principles. Medical advancements and the development of life-sustaining interventions often require patients to make difficult decisions about options for medical care in times of immense emotional distress. The decision to start dialysis because of acute kidney injury (AKI) may pose an ethical dilemma in the case of some older patients; similarly, older patients with unexpectedly rapid progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD) may have comorbid conditions that undermine the success of dialysis in prolonging quality in addition to quantity of life. Finally, continuing to dialyze patients whose functional or clinical status has declined poses an ethical dilemma for nephrologists, especially when patients are no longer able to participate in decisions about their own care. This chapter explores the ethical aspects of end-of-life decision making in older patients facing major life transitions and decisions related to (1) the pursuit of dialysis because of AKI, (2) the consideration of dialysis when there is progression of CKD to ESRD, and (3) the continuation or withdrawal of dialysis in patients whose clinical status has changed since the initiation of dialysis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Moss AH (2012) To dialyze or not: the patient with metastatic cancer and AKI in the Intensive Care Unit. Clin J Am Soc Nephrol 10:1–6

    Google Scholar 

  2. Dennen P, Douglas IS, Anderson R (2010) Acute kidney injury in the intensive care unit: an update and primer for the intensivist. Crit Care Med 38:261–275

    Article  PubMed  Google Scholar 

  3. Ostermann M, Chang RWS (2007) Acute kidney injury in the intensive care unit according to RIFLE. Crit Care Med 35:1837–1843

    Article  PubMed  Google Scholar 

  4. Uchino S, Kellum JA, Bellomo R et al (2005) Beginning and ending supportive therapy for the kidney (BEST Kidney) Investigators: acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294:813–818

    Article  PubMed  CAS  Google Scholar 

  5. Mehta RL, Pascual MT, Soroko S et al (2004) Program to improve care in acute renal disease: spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 66:613–1621

    Article  Google Scholar 

  6. Liaño F, Felipe C, Tenorio MT et al (2007) Long-term outcome of acute tubular necrosis: a contribution to its natural history. Kidney Int 71:679–686

    Article  PubMed  Google Scholar 

  7. Kurella M, Covinsky KE, Collins AJ, Chertow GM (2007) Octogenarians and nonagenarians starting dialysis in the United States. Ann Intern Med 146:177–183

    Article  PubMed  Google Scholar 

  8. Renal Data System US (2009) USRDS 2009 Annual Data Report: atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda

    Google Scholar 

  9. Schmidt R (2012) Informing our elders about dialysis: is an age-attuned approach warranted? Clin J Am Soc Nephrol 7:1–7

    Article  Google Scholar 

  10. Bagshaw SM (2008) Short- and long-term survival after acute kidney injury. Nephrol Dial Transplant 23:2126–2128

    Article  PubMed  Google Scholar 

  11. Bagshaw SM, Laupland KB, Doig CJ et al (2005) Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study. Crit Care 9:R700–R709

    Article  PubMed  Google Scholar 

  12. Schmitt R, Coca S, Kanbay M, Tinetti ME, Cantley LG, Parikh CR (2008) Recovery of kidney function after acute kidney injury in the elderly: a systemic review and meta-analysis. Am J Kidney Dis 52:262–271

    Article  PubMed  Google Scholar 

  13. Banerjee D, Ma JZ, Collins AJ, Herzog CA (2007) Long-term survival of incident hemodialysis patients who are hospitalized for congestive heart failure, pulmonary edema, or fluid overload. Clin J Am Soc Nephrol 2:1186–1190

    Article  PubMed  Google Scholar 

  14. Harnett JD, Foley RN, Kent GM, Barre PE, Murray D, Parfrey PS (1995) Congestive heart failure in dialysis patients: prevalence, incidence, prognosis and risk factors. Kidney Int 47:884–890

    Article  PubMed  CAS  Google Scholar 

  15. Issen AC (2011) Difficult decisions about care and treatment in end-stage renal disease. www.hospiceofthecomforter.org. pp 4–9.

  16. Renal Physicians Association (2010) Clinical practice guideline for shared decision making in the appropriate initiation and withdrawal from dialysis, 2nd edn. Renal Physicians Association, Rockville

    Google Scholar 

  17. Smith C, Da-Silva-Gane M, Chandna S, Warwicker P, Greenwood R, Farrington K (2003) Choosing not to dialyse: evaluation of planned non-dialytic management in a cohort of patients with end-stage renal failure. Nephron Clin Pract 95:c40–c46

    Article  PubMed  Google Scholar 

  18. Carson RC, Juszczak M, Davenport A, Burns A (2009) Is maximum conservative management an equivalent treatment option to dialysis for elderly patients with significant comorbid disease? Clin J Am Soc Nephrol 4:1611–1619

    Article  PubMed  Google Scholar 

  19. Wong CF, McCarthy M, Howse ML, Williams PS (2007) Factors affecting survival in advanced chronic kidney disease patients who choose not to receive dialysis. Ren Fail 29:653–659

    Article  PubMed  CAS  Google Scholar 

  20. Ellam T, El-Kossi M, Prasanth KC, El-Nahas M, Khwaja A (2009) Conservatively managed patients with stage 5 chronic kidney disease-outcomes from a single center experience. QIM 102:547–554

    Article  CAS  Google Scholar 

  21. Murtagh FE, Marsh JE, Donohoe P, Ekbal NJ, Sheerin NS, Harris FE (2007) Dialysis or not? A comparative survival study of patients over 75 years with chronic kidney disease stage 5. Nephrol Dial Transplant 22:1955–1962

    Article  PubMed  Google Scholar 

  22. Kaufman SR, Shim JK, Russ AJ (2004) Revisiting the biomedicalization of aging: clinical trends and ethical challenges. Gerontologist 44:731–738

    Article  PubMed  Google Scholar 

  23. Touchcalc. www.touchcalc.com. Accessed 8 Feb 2013

  24. Dalrymple LS, Katz R, Kestenbaum B et al (2011) Chronic kidney disease and the risk of end-stage renal disease versus death. J Gen Intern Med 26:379–385

    Article  PubMed  Google Scholar 

  25. Moss AH, Ganjoo J, Sharma S et al (2008) Utility of the “surprise” question to identify dialysis patients with high mortality. Clin J Am Soc Nephrol 3:1379–1384

    Article  PubMed  Google Scholar 

  26. Cohen LM, Ruthazer R, Moss AH, Germain MJ (2010) Predicting six-month mortality for patients who are on maintenance hemodialysis. Clin J Am Soc Nephrol 5:72–79

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sana R. Akbar MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Akbar, S.R., Schmidt, R.J. (2014). End-of-Life Decision Making in Older Patients with Acute Kidney Injury and End-Stage Renal Disease: Ethical Perspectives. In: Haase, M., Haase-Fielitz, A. (eds) Managing Renal Injury in the Elderly Patient. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39947-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-39947-3_9

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-39946-6

  • Online ISBN: 978-3-642-39947-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics