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Other Binary Genodermatoses, Including “Pseudodidymosis”

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Mosaicism in Human Skin

Abstract

Phacomatosis pigmentokeratotica can certainly be taken as a binary genodermatosis because such coexistence of papular nevus spilus and nevus sebaceus is rather often noted. This phenotype represents as an example of pseudodidymosis because both nevus sebaceus and papular nevus spilus originate form one single HRAS mutation present in a heterozygous state. Similarly, the coexistence of sebaceous nevus with melorheostosis or with aplasia cutis congenita can no longer be explained as a didymosis. – The paired occurrence of vascular and pigmentary nevi have likewise been taken as possible examples of twin spotting. Again, this assumption should today be regarded with great caution.

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Authors and Affiliations

  1. Department of Dermatology, Freiburg University Medical Center, Freiburg, Germany

    Rudolf Happle

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Happle, R. (2014). Other Binary Genodermatoses, Including “Pseudodidymosis”. In: Mosaicism in Human Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38765-4_9

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  • DOI: https://doi.org/10.1007/978-3-642-38765-4_9

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  • Print ISBN: 978-3-642-38764-7

  • Online ISBN: 978-3-642-38765-4

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