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Membranous Nephropathy in Children

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Pediatric Nephrology

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Abstract

Membranous nephropathy (MN), also known as membranous glomerulonephritis, is a pathologic condition associated with an immune complex deposition within the glomerulus resulting in glomerular dysfunction. Clinical manifestations of MN include proteinuria, hematuria, overt nephrotic syndrome, and in some cases renal dysfunction. In adults, MN is the most common primary glomerulopathy associated with the nephrotic syndrome, accounting for approximately 25–35 % of adults diagnosed with this condition [1–3]. In children, MN may present as the nephrotic syndrome or as asymptomatic proteinuria and is considered to a much less common condition than that seen in adults [4, 5]. MN may be idiopathic or secondary to infections, autoimmune diseases, or medications. Recent breakthrough discoveries regarding the pathogenesis of idiopathic MN have reenergized the field and should aid clinicians going forward with regard to developing novel means to monitor and treat patients with membranous nephropathy [6–8].

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Authors and Affiliations

  1. Pediatric Nephrology, Children’s Hospital of Michigan, Detroit, MI, USA

    Rudolph P. Valentini

  2. Wayne State University School of Medicine, Detroit, MI, USA

    Rudolph P. Valentini

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  1. Rudolph P. Valentini
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Correspondence to Rudolph P. Valentini .

Editor information

Editors and Affiliations

  1. Children's Hospital of Wisconsin Children's Research Institute, Milwaukee, Wisconsin, USA

    Ellis D. Avner

  2. Harvard Medical School Children's Hospital Boston, Boston, Massachusetts, USA

    William E. Harmon

  3. Hôpital Necker Enfants Malades Dept. Néphrologie Pédiatrique, Paris, France

    Patrick Niaudet

  4. Wakayama Medical University Dept. Pediatrics, Wakayama City, Japan

    Norishige Yoshikawa

  5. Department of Nephrology and Urology Division of Nephrology, Children's Hospital Bambino Gesù, IRCCS, Rome, Italy

    Francesco Emma

  6. Division of Nephrology and Hypertension The Heart Institute, University of Cincinnati Cincinnati Children’s Hospital Medical C, Cincinnati, Ohio, USA

    Stuart Goldstein

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Valentini, R.P. (2014). Membranous Nephropathy in Children. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27843-3_30-1

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  • DOI: https://doi.org/10.1007/978-3-642-27843-3_30-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27843-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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