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Posterior Pituitary Hormones

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

Several authors, such as Dale and Laidlaw (1912), Fromherz (1926), Glaubach and Molitor (1932), Lipschitz and Klar (1933), and Simon (1933), used the isolated uterus of virgin guinea pigs as a sensitive test for determination of oxytocin activity. The isolated uterus of the rat (Holton 1948) is less sensitive, but, in contrast to the guinea pig, the rat uterus shows no spontaneous contractions in solutions with low calcium and glucose concentrations. Historically, the method has been adopted by several pharmacopoeias, e.g., by the British Pharmacopoeia (1988). The United States Pharmacopeia 23 (1995) uses the isolated guinea pig uterus for determination of oxytocin activity in vasopressin preparations. Physicochemical assays are now used for standardizing drug content, instead of the biological responses.

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References and Further Reading

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  1. Frankfurt-Main University, Centre of Pharmacology, Glashuetten, Germany

    Jürgen Sandow

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  1. Jürgen Sandow
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Correspondence to Jürgen Sandow .

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  1. Dieburg, Germany

    Franz J. Hock

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Sandow, J. (2015). Posterior Pituitary Hormones. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_82-1

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