Abstract
The search for optimal nanoparticlesfor magnetic particle imaging (MPI) has been receiving much attention. Currently, Resovist® an iron oxide nanoparticle-based MR contrast agent is considered as the gold standard for MPS and MPI measurements. In this paper, we evaluate the initial MPS response of iron oxide-based nanoparticle systems with variation in core size and coating. In this context, we synthesized iron oxide nanoparticles with different core sizes (5 and 10 nm) by employing co-preciptiation method. Further, these iron cores were adsorptivelycoated with endogenous fluorophores (flavin analogues: FMN, FAD) to increase their stability and to enhance MR contrast. We have performed initial experiments on these particles in a magnetic particle spectrometer. Their spectrum of higher harmonics was obtained and found to fall off more rapidly than Resovist®. No difference in magnetic behavior was seen between particles with different coatings.
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Jayapaul, J., Truhn, D., Kiessling, F., Lüdtke-Buzug, K., Buzug, T.M. (2012). Initial MPS Response of Adsorptively-Coated Fluorescent Iron Oxide Nanoparticles. In: Buzug, T., Borgert, J. (eds) Magnetic Particle Imaging. Springer Proceedings in Physics, vol 140. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24133-8_8
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DOI: https://doi.org/10.1007/978-3-642-24133-8_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-24132-1
Online ISBN: 978-3-642-24133-8
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