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Carcinoma of the Biliary Tract

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Gastrointestinal Oncology

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Abstract

The gallbladder and bile ducts share a common embryologic origin and are lined with a simple columnar epithelium. Most malignancies of the biliary tract are adenocarcinomas that arise from the malignant transformation of this columnar epithelium. Adenocarcinomas of the bile ducts are often referred to as cholangiocarcinomas. Malignant transformation can occur anywhere along the biliary system from the ampulla of Vater to the terminal intrahepatic bile ducts. Gallbladder cancers arise from the epithelium of the gallbladder or cystic duct. Intrahepatic cholangiocarcinoma (ICC) develops in bile ducts within the liver and proximal to the lobar hepatic ducts and hepatic duct confluence. Extrahepatic bile duct cancer develops in the biliary tree from the ampulla of Vater to the hepatic duct confluence. Extrahepatic bile duct tumors can be further subdivided into intrapancreatic cholangiocarcinoma, which are managed similarly to other periampullary malignancies (and are not discussed here), and proximal or hilar cholangiocarcinoma.

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Authors and Affiliations

  1. Department of Radiation Oncology, University Health Network, Princess Margaret Hospital, 610 University Ave, Toronto, ON, M5G 2M9, Canada

    Laura Ann Dawson

  2. Division of General Surgery, Department of Surgery, University Health Network, Toronto General Hospital, Toronto, ON, Canada

    Sean P. Cleary

  3. Department of Medical Oncology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada

    Jennifer Knox

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  1. Sean P. Cleary
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  2. Jennifer Knox
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  3. Laura Ann Dawson
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Correspondence to Laura Ann Dawson .

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  1. Div. Medical Oncology, University of British Columbia, West 10th Avenue 600, Vancouver, V5Z 4E6, British Columbia, Canada

    Charles D. Blanke

  2. FB 19 Zentrum der Radiologie, Klinik f. Strahlentherapie, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, Frankfurt, 60590, Germany

    Claus Rödel

  3. Evanston Northwestern Healthcare, Northwestern University, Ridge Ave. 2650, Evanston, 60201, Illinois, USA

    Mark S. Talamonti

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Cleary, S.P., Knox, J., Dawson, L.A. (2011). Carcinoma of the Biliary Tract. In: Blanke, C., Rödel, C., Talamonti, M. (eds) Gastrointestinal Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13306-0_10

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