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Tumors of the Skull Base

  • Chapter
Oncology of CNS Tumors

Abstract

The skull base is affected by a wide range of tumor pathologies. They are often slow-growing, benign, extra-axial tumors that cause symptoms by involvement of the cranial nerves or a mass effect on the brain stem and cerebellum. They are often located in critical areas within the cranium that are especially hard to reach with routine surgical techniques. Involvement of cranial nerves and vessels makes these lesions particularly challenging to treat surgically. Due to the benign nature of most of these lesions, complete surgical removal often affords a cure, although some skull-base tumors require a combination of surgical and radiation therapies.

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References

  1. Surawicz TS, McCarthy BJ, Kupelian V. (1999) Descriptive epidemiology of primary brain and CNS tumors: results from the central brain tumor registry of the United States. Neuro-oncology 1(1):14–25

    PubMed  CAS  Google Scholar 

  2. Heffelfinger MJ, Dahlin DC, MacCarty CS, Beabout JW. (1973) Chordomas and cartilaginous tumors at the skull base. Cancer 32(2):410–420

    Article  PubMed  CAS  Google Scholar 

  3. Krayenbuhl H, Yasargil MG. (1975) Cranial Chordomas. Prg Neurol Surg 6:380–434

    Google Scholar 

  4. Borba LA, Al-Mefty O, Mrak RE, Suen J. (1996) Cranial chordomas in children and adolescents. J Neurosurg 84 (4):584–591

    Article  PubMed  CAS  Google Scholar 

  5. al-Mefty O, Borba LA. (1997) Skull base chordomas: a management challenge. J Neurosurg 86(2):182–189

    Article  PubMed  CAS  Google Scholar 

  6. Colli B, Al-Mefty O. (2001) Chordomas of the craniocervi-cal junction: follow-up review and prognostic factors. J Neurosurg 95(6):933–943

    Article  PubMed  CAS  Google Scholar 

  7. Arnautovic KI, Al-Mefty O. (2001) Surgical seeding of chordomas. J Neurosurg 95(5):798–803

    Article  PubMed  CAS  Google Scholar 

  8. Hug EB, Loredo LN, Slater JD, DeVries A, Grove RI, Schaefer RA, Rosenberg AE, Slater JM. (1999) Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg 91(3):432–439

    Article  PubMed  CAS  Google Scholar 

  9. Munzenrider JE, Liebsch NJ. (1999) Proton therapy for tumors of the skull base. Strahlenther Onkol 175(Suppl 2):57–63

    Article  PubMed  Google Scholar 

  10. Casali PG, Messina A, Stacchiotti S, Tamborini E, Crippa F, Gronchi A, Orlandi R, Ripamonti C, Spreafico C, Bertieri R, Bertulli R, Colecchia M, Fumagalli E, Greco A, Grosso F, Olmi P, Pierotti MA, Pilotti S. (2004) Imatinib mesylate in chordoma. Cancer 101(9):2086–2097

    Article  PubMed  CAS  Google Scholar 

  11. Ron E, Modan B, Joice JD, Alfandary E, Stovall M, Chetrit A, et al (1988) Tumors of the brain and nervous system after radiotherapy in childhood. New England Journal of Medicine 319:1033–1039

    Article  PubMed  CAS  Google Scholar 

  12. Al-Mefty O, Topsakal C, Pravdenkova S, Sawyer JR, Harrison MJ. (2004) Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics. J Neurosurgery 100(6):1002–1

    Article  Google Scholar 

  13. Maini CL, Sciuto R, Tofani A, Ferraironi A, Carapella CM, Occhipinti E, Mottolese M, Crecco M. (1995) Somatostatin receptor imaging in CNS tumours using 111In-octreotide. Nucl Med Commun 16(9):756–766

    Article  PubMed  CAS  Google Scholar 

  14. Kleihues P, Cavenee W (eds). (2000) World Health Organization classification of tumors: pathology and genetics of tumors of the nervous sytem. IARC Press, Lyon, France

    Google Scholar 

  15. Perry A, Stafford SL, Scheithauer BW, Suman VJ, Lohse CM. (1997) Meningioma grading: an analysis of his-tologic parameters. Am J Surg Pathol 21(12):1455–1465

    Article  PubMed  CAS  Google Scholar 

  16. Perry A, Scheithauer BW, Stafford SL, Lohse CM, Wollan PC. (1999) “Malignancy” in meningiomas: a clini-copathologic study of 116 patients, with grading implications. Cancer 85(9):2046–2056

    PubMed  CAS  Google Scholar 

  17. Al-Mefty O, Kadri PA, Pravdenkova S, Sawyer JR, Stangeby C, Husain M. (2004) Malignant progression in meningioma: documentation of a series and analysis of cyto-genetic findings. J Neurosurg 101(2):210–218

    Article  PubMed  Google Scholar 

  18. Cushing h, Eisenhardt L. (1938) Meningiomas: their classi-fication, regional behaviour, life history, and surgical end results. Charles c Thomas, Springfield, IL

    Google Scholar 

  19. Pieper DR, Al-Mefty O, Hanada Y, Buechner D. (1999) Hyperostosis associated with meningioma of the cranial base: secondary changes or tumor invasion. Neurosurgery 44(4):742–746; discussion 746–747

    Article  PubMed  CAS  Google Scholar 

  20. Al-Mefty O. (1990) Clinoidal meningiomas. J Neurosurg 73(6):840–849

    Article  PubMed  CAS  Google Scholar 

  21. DeMonte F, Smith HK, al-Mefty O. (1994) Outcome of aggressive removal of cavernous sinus meningiomas. J Neurosurg 81(2):245–251

    Article  PubMed  CAS  Google Scholar 

  22. Arnautovic KI, Al-Mefty O. (2002) Primary meningiomas of the jugular fossa. J Neurosurg 97(1):12–20

    Article  PubMed  Google Scholar 

  23. Simpson D. (1957) The recurrence of intracranial menin-giomas after surgical treatment. J Neurochem 20(1):22–39

    CAS  Google Scholar 

  24. Pollock BE, Stafford SL, Utter A, Giannini C, Schreiner SA. (2003) Stereotactic radiosurgery provides equivalent tumor control to Simpson Grade 1 resection for patients with small-to medium-size meningiomas. Int J Radiat Oncol Biol Phys 55(4):1000–1005

    Article  PubMed  Google Scholar 

  25. Borba LA, Al-Mefty O. (1996) Intravagal paragangliomas: report of four cases. Neurosurgery 38(3):569–575; discussion 575

    PubMed  CAS  Google Scholar 

  26. Fisch U. (1982) Infratemporal fossa approach for glomus tumors of the temporal bone. Ann Otol Rhinol Laryngol 91(5 Pt 1):474–479

    PubMed  CAS  Google Scholar 

  27. Jackson CG, Glasscock ME 3rd, McKennan KX, Koopmann CF Jr, Levine SC, Hays JW, Smith HP. (1987) The surgical treatment of skull-base tumors with intracranial extension. Otolaryngol Head Neck Surg 96(2):175–185

    PubMed  CAS  Google Scholar 

  28. Al-Mefty O, Teixeira A. (2002) Complex tumors of the glo-mus jugulare: criteria, treatment, and outcome. J Neurosurg 97(6):1356–1366

    Article  PubMed  Google Scholar 

  29. Kadri PA, Al-Mefty O. (2004) Surgical treatment of dumbbell-shaped jugular foramen schwannomas. Neurosurg Focus 17(2):E9

    Article  PubMed  Google Scholar 

  30. Gottfried ON, Liu JK, Couldwell WT. (2004) Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumors. Neurosurg Focus 17(2):E4

    Article  PubMed  Google Scholar 

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Erkmen, K., Al-Mefty, O., Adada, B. (2010). Tumors of the Skull Base. In: Tonn, JC., Westphal, M., Rutka, J.T. (eds) Oncology of CNS Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02874-8_17

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  • DOI: https://doi.org/10.1007/978-3-642-02874-8_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02873-1

  • Online ISBN: 978-3-642-02874-8

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