Abstract
The preceding chapter showed that the regulation of enzymatic activity can be carried out through a variety of mechanisms. Regulation involving covalent processes is even more diverse. These processes include various co- and post-translational events such as limited proteolysis and various chemical modifications (glycosylation, carboxylation, ADP-ribosylation etc.). They also involve mechanisms of enzyme phosphorylation-dephosphorylation, catalysed by specific enzymes, as a function of the cell’s metabolic needs or in response to signals.
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Bibliography
Books
Alberts B. et al. –1983– Molecular Biology of the Cell, Garland publisher, New York.
General Reviews
Coux O., Tanaka K. & Goldberg A.L. –1996– Structure and function of the 20 s and 26 s proteasome, in Annu. Rev. Biochem. 65, 801.
Grütter M.G. –2000– Caspases: key players in programmed cell death, in Curr. Op. Struct. Biol. 10, 649–655.
Hayes B.K. & Hart G. –1994– Novel forms of protein glycosylation, in Curr. Op. Struct. Biol. 4, 692–696.
Hengartner M.O. –2000– The biochemistry of apoptosis, in Nature 407, 770–776.
Laskowski M. JR & Kato I. –1980– Protein inhibitors of proteinases, in Annu. Rev. Biochem. 49, 593–626.
Stadtman E.R. & Chock P.B. –1978– Interconvertible enzyme cascades in metabolic regulation, in Curr. Top. Cell. Regul. 13, 53–95.
Specialised Articles
Ahn K., Erlander M., Leturcq D., Peterson P.A., Früh K & Yang Y. –1996– J. Biol. Chem. 271, 18237.
Almassy R.J., Janson C.A., Hamlin R., Xuong N.H. & Eisenberg D. –1986– Nature 323, 304.
Barford D., Hu S.H. & Johnson L.N. –1991– J. Mol. Biol. 218, 233.
Bode W. & Huber R. –1992– Eur. J. Biochem. 204, 433.
Carrell R.W., Evans D.L. & Stein P.E. –1991– Nature 353, 576.
Chambon P., Weill J.D., Doly J., Strosser M.T. & Mandel P. –1966– Biochem. Biophys. Res. Commun. 25, 638.
Davie E.W., Fujikawa K. & Kisiel W. –1991– Biochemistry 30, 10363.
Fisher E.H. & Krebs E.G. –1955– J. Biol. Chem. 216, 121.
Gaal J.C. & Pearson C.K. –1986– Trends Biochem. Sci. 11, 171.
Gaboriaud G., Rossi V., Bally I., Arland G.J. & Fontecilla-Camps J.C. –2000– Embo. J. 19, 1755.
Groll M., Ditzel L., Stock D., Bochtler M., Bartunik H. & Hiber R. –1997– Nature 386, 463.
Hanks S.K. & Quinn A.M. –1991– Methods Enzymol. 200, 38.
Hervé M. & Ghélis C. –1991– Arch. Biochem. Biophys. 285, 142.
Hunter T. –1991– Methods Enzymol. 200, 3.
Knighton D.R., Zheng J., Ten Eyck L.F., Ashford V.A., Xuong N.H., Taylor S.S. & Sowadski J.M. –1991– Science 253, 407 and 414.
Kobata A. –1995– Glycobiology, in Molecular Biology and Biotechnology, R.A. Meyers ed., New York, 382–385.
Löwe J., Stock D., Jap B., Awicker P., Baumeister W. & Huber R. –1995– Science 268, 533.
Marchase R.B., Bounelis P., Brumley L.M., Dey N., Browne B., Auger D., Fritz T.A., Kulesza P. & Bedwell D.M. –1993– J. Biol. Chem. 268, 8341.
Nicholson D.W. & Thornberry N.A. –1997– TIBS 22, 299.
Ray A.K., Datta B., Chakraborty A., Chattopadhyay A., Meza-Keuther S. & Gupta N.K. –1992– Proc. Natl. Acad. Sci. USA 89, 539.
Shall S. –1995– Biochimie 77, 313.
Sprang S.R., Acharya K.R., Goldsmith E.J., Stuart D.I., Varvill K., Fetterick R.J., Madsen N.B. & Johnson L.N. –1988– Nature 336, 215.
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Yon-Kahn, J., Hervé, G. (2009). Regulation by Covalent Modification. In: Molecular and Cellular Enzymology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01228-0_15
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DOI: https://doi.org/10.1007/978-3-642-01228-0_15
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