Reaction of hydrazine or substituted hydrazine with 1,3-dicarbonyl compounds to provide the pyrazole or pyrazolone ring system. Cf. Paal–Knorr pyrrole synthesis (page 411).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
(a) Knorr, L. Ber 1883, 16, 2597. Ludwig Knorr (1859–1921) was born near Munich, Germany. After studying under Volhard, Emil Fischer, and Bunsen, he was appointed professor of chemistry at Jena. Knorr made tremendous contributions in the synthesis of heterocycles in addition to discovering the important pyrazolone drug, pyrine. (b) Knorr, L. Ber 1884, 17, 546, 2032. (c) Knorr, L. Ber. 1885, 18, 311. (d) Knorr, L. Ann. 1887, 238, 137.
Burness, D. M. J. Org. Chem. 1956, 21, 97–101.
Jacobs, T. L. in Heterocyclic Compounds, Elderfield, R. C., Ed.; Wiley: New York, 1957, 5, 45. (Review).
Houben–Weyl, 1967, 10/2, 539, 587, 589, 590. (Review).
Elguero, J., In Comprehensive Heterocyclic Chemistry II, Katrizky, A. R.; Rees, C. W.: Scriven, E. F. V., Eds; Elsevier: Oxford, 1996, 3, 1. (Review).
Stanovnik, E.; Svete, J. In Science of Synthesis, 2002, 12, 15; Neier, R., Ed.; Thieme. (Review).
Sakya, S. M. Knorr Pyrazole Synthesis. In Name Reactions in Heterocyclic Chemistry; Li, J. J., Corey, E. J., Eds, Wiley & Sons: Hoboken, NJ, 2005, pp 292–300. (Review).
Ahlstroem, M. M.; Ridderstroem, M.; Zamora, I.; Luthman, K. J. Med. Chem. 2007, 50, 4444–4452.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Li, J.J. (2009). Knorr pyrazole synthesis. In: Name Reactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01053-8_139
Download citation
DOI: https://doi.org/10.1007/978-3-642-01053-8_139
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-01052-1
Online ISBN: 978-3-642-01053-8
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)