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Hepatic Regeneration

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Clinical Hepatology
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References

  1. Akerman P, Cote P, Yang SQ, et al (1992) Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol 263: G579–85

    CAS  PubMed  Google Scholar 

  2. Alison M, Sarraf C (1998) Hepatic stem cells. J Hepatol 29: 676–82

    Article  CAS  PubMed  Google Scholar 

  3. Alison M, Poulsom R, Jeffrey R, et al (2000) Hepatocytes from non-hepatic cells. Nature 406: 257

    Article  CAS  PubMed  Google Scholar 

  4. Alvaro D, Gigliozzi A, Attili AF (2000) Regulation and deregulation of cholangiocyte proliferation. J Hepatol 33: 333–40

    Article  CAS  PubMed  Google Scholar 

  5. Assy N, Minuk GY (1997) Liver regeneration: methods for monitoring and their applications. J Hepatol 26: 945–52

    Article  CAS  PubMed  Google Scholar 

  6. Berasain C, Garcia-Trevijano ER, Castillo J, et al (2005) Amphiregulin: an early trigger of liver regeneration in mice. Gastroenterology 128: 424–32

    Article  CAS  PubMed  Google Scholar 

  7. Block GD, Locker J, Bowen WC, et al 1996) Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J Cell Biol 132: 1133–49

    Article  CAS  PubMed  Google Scholar 

  8. Bottaro DP, Rubin JS, Faletto DL, et al (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251: 802–4

    Article  CAS  PubMed  Google Scholar 

  9. Bralet MP, Branchereau S, Brechot C, et al (1994) Cell lineage study in the liver using retroviral mediated gene transfer. Evidence against the streaming of hepatocytes in the normal liver. Am J Pathol 144: 896–905

    CAS  Google Scholar 

  10. Bucher NLR, Strain AJ (1992) Regulatory mechanisms in hepatic regeneration. In: Millward-Sadler GH, Wright R, Arthur MJP (eds) Wright's liver and biliary diseases. Pathophysiology, diagnosis and management, 3rd edn. W.B. Saunders, Philadelphia, PA, pp 258–74

    Google Scholar 

  11. Campbell JS, Prichard L, Schaper F, et al (2001) Expression of suppressors of cytokine signaling during liver regeneration. J Clin Invest 107: 1285–92

    Article  CAS  PubMed  Google Scholar 

  12. Cressman DE, Greenbaum LE, DeAngelis RA, et al (1996) Liver failure and defective regeneration in interleukin-6-deficient mice. Science 274: 1379–83

    Article  CAS  PubMed  Google Scholar 

  13. Crosby HA, Strain AJ (2001) Adult liver stem cells: bone marrow, blood, or liver derived? Gut 48: 153–54

    Article  CAS  PubMed  Google Scholar 

  14. Date M, Matsuzaki K, Matsushita M, et al (2000) Modulation of transforming growth factor β function in hepatocytes and hepatic stellate cells in rat liver injury. Gut 46: 719–24

    Article  CAS  PubMed  Google Scholar 

  15. De Vos R, Desmet V (1992) Ultrastructural characteristics of novel epithelial cell types identified in human pathologic liver specimens with chronic ductular reaction. Am J Pathol 140: 1441–50

    PubMed  Google Scholar 

  16. Diehl AM (2000) Cytokine regulation of liver injury and repair. Immunol Rev 174: 160–71

    Article  CAS  PubMed  Google Scholar 

  17. Falkowski O, An HJ, Ianus IA, et al (2003) Regeneration of hepatocyte “buds” in cirrhosis from intrabiliary stem cells. J Hepatol 39: 357–64

    Article  CAS  PubMed  Google Scholar 

  18. Fausto N (2000) Liver regeneration. J Hepatol 32(Suppl. 1) 19–31

    Article  CAS  PubMed  Google Scholar 

  19. Fausto N (2004) Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 39: 1477–87

    Article  PubMed  Google Scholar 

  20. Fausto N, Campbell JS, Riehle KJ (2006) Liver regeneration. Hepatology 43: S45–53

    Article  CAS  PubMed  Google Scholar 

  21. Fausto N, Mead JE (1989) Regulation of liver growth: protoon-cogenes and transforming growth factors. Lab Invest 60: 4–13

    CAS  PubMed  Google Scholar 

  22. Gehling UM, Willems M, Dandri M, et al (2005) Partial hepa-tectomy induces mobilization of a unique population of haematopoietic progenitor cells in human healthy liver donors. J Hepatol 43: 845–53

    Article  CAS  PubMed  Google Scholar 

  23. Heo J, Factor VM, Uren T, et al (2006) Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver. Hepatology 44: 1478–86

    Article  CAS  PubMed  Google Scholar 

  24. Higgins GM, Anderson RM (1931) Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 12: 186–202

    Google Scholar 

  25. Kim TH, Mars WM, Stolz DB, et al (2000) Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration. Hepatology 30: 75–82

    Article  Google Scholar 

  26. Lesurtel M, Graf R, Aleil B, et al (2006) Platelet-derived serotonin mediates liver regeneration. Science 312: 104–7

    Article  CAS  PubMed  Google Scholar 

  27. Malik R, Mellor N, Selden C, et al (2003) Triiodothyronine enhances the regenerative capacity of the liver following partial hepatectomy. Hepatology 37: 79–86

    Article  CAS  PubMed  Google Scholar 

  28. Marti U, Burwen SJ, Jones AL (1989) Biological effects of epidermal growth factor, with emphasis on the gastrointestinal tract and liver: an update. Hepatology 9: 126–38

    Article  CAS  PubMed  Google Scholar 

  29. Michalopoulos GK (1990) Liver regeneration: molecular mechanisms of growth control. FASEB J 4: 176–87

    CAS  PubMed  Google Scholar 

  30. Michalopoulos GK, Bowen WC, Mule K, et al (2002) Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology 36: 278–83

    Article  CAS  PubMed  Google Scholar 

  31. Michalopoulos GK, DeFrances M (2005) Liver regeneration. Adv Biochem Eng Biotechnol 93: 101–34

    CAS  PubMed  Google Scholar 

  32. Miyazawa K, Tsubouchi H, Naka D, et al (1989) Molecular cloning and sequence analysis of cDNA for human hepato-cyte growth factor. Biochem Biophys Res Commun 163: 967–73

    Article  CAS  PubMed  Google Scholar 

  33. Nagaki M, Sugiyama A, Naiki T, et al (2000) Control of cyclins, cyclin-dependent kinase inhibitors, p21 and p27, and cell cycle progression in rat hepatocytes by extracellular matrix. J Hepatol 32: 488–96

    Article  CAS  PubMed  Google Scholar 

  34. Nakamura T, Nishizawa T, Hagiya M, et al (1989) Molecular cloning and expression of human hepatocyte growth factor. Nature 342: 440–43

    Article  CAS  PubMed  Google Scholar 

  35. Oh SH, Witek RP, Bae SH, et al (2007) Bone marrow-derived hepatic oval cells differentiate into heapatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration. Gastroenterology 132: 1077–87

    Article  CAS  PubMed  Google Scholar 

  36. Olle EW, Ren X, McClintock SD, et al (2006) Matrix metal-loproteinase-9 is an important factor in regeneration after partial hepatectomy in mice. Hepatology 44: 540–9

    Article  CAS  PubMed  Google Scholar 

  37. Peters M, Blinn G, Jostock T, et al (2000) Combined inter-leukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration. Gastroenterology 119: 1663–71

    Article  CAS  PubMed  Google Scholar 

  38. Petersen BE, Bowen WC, Patrene KD, et al (1999) Bone marrow as a potential source of hepatic oval cells. Science 284: 1168–70

    Article  CAS  PubMed  Google Scholar 

  39. Ren X, Hogaboam C, Carpenter, et al (2003) Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy. J Clin Invest 112: 1407–18

    CAS  PubMed  Google Scholar 

  40. Roskams T, DeVos R, van Eyken P, et al (1998) Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man. J Hepatol 29: 455–63

    Article  CAS  PubMed  Google Scholar 

  41. Simpson KJ, Lukas NW, Colletti L, et al (1997) Cytokines and the liver. J Hepatol 27: 1120–32

    Article  CAS  PubMed  Google Scholar 

  42. Strain AJ (1988) Transforming growth factor-b and inhibition of hepatocellular proliferation. Scand J Gastroenterol 23(Suppl. 151) 37–45

    Article  Google Scholar 

  43. Strain AJ, Crosby HA (2000) Hepatic stem cells. Gut 46: 743–45

    Article  CAS  PubMed  Google Scholar 

  44. Streetz KL, Luedde T, Manns MP, et al (2000) Interleukin 6 and liver regeneration. Gut 47: 309–12

    Article  CAS  PubMed  Google Scholar 

  45. Suzuki A, McCall S, Choi SS, et al (2006) Interleukin-15 increases hepatic regenerative activity. J Hepatol 45: 410–8

    Article  CAS  PubMed  Google Scholar 

  46. Taub R (2003) Hepatoprotection via the IL-6/Stat3 pathway. J Clin Invest 112: 978–80

    CAS  PubMed  Google Scholar 

  47. Taub R (2004) Liver regeneration: from myth to mechanism. Nature Reviews 5: 836–47

    Article  CAS  PubMed  Google Scholar 

  48. Theise ND, Badve S, Saxena R, et al (2000) Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 31: 235–40

    Article  CAS  PubMed  Google Scholar 

  49. Theise ND, Nimmakayalu M, Gardner R, et al (2000) Liver from bone marrow in humans. Hepatology 32: 11–6

    Article  CAS  PubMed  Google Scholar 

  50. Van den Heuvel MC, Gouw ASH, Boot M, et al (2006) The finest branches of the biliary tree might induce biliary vasculari-sation necessary for biliary regeneration. J Hepatol 44: 947–55

    Article  PubMed  Google Scholar 

  51. Vig P, Russo FP, Edwards RJ, et al (2006) The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice. Hepatology 43: 316–24

    Article  PubMed  Google Scholar 

  52. Wilson JW, Leduc EH (1958) Role of cholangioles in restoration of the liver of the mouse after dietary injury. J Pathol Bacteriol 76: 441–49

    Article  CAS  PubMed  Google Scholar 

  53. Zajjcek G, Oren J, Weinreb M (1985) The streaming liver. Liver 5: 295–300

    Google Scholar 

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Dancygier, H. (2010). Hepatic Regeneration. In: Clinical Hepatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-93842-2_13

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  • DOI: https://doi.org/10.1007/978-3-540-93842-2_13

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