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Deciphering the Conundrum of Estrogen-driven Breast Cancer: Aurora Kinase Deregulation

  • Conference paper
Hormonal Control of Cell Cycle

Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

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Abstract

Of all cancers occurring in women in developed countries, breast cancer (BC) accounts for ~32%; obviously a world-wide public health concern. More than 90% of all breast cancer cases are sporadic/non-familial, and largely ductal carcinomas. Estrogens have a profound role in BC causation and progression. Although estrogen receptor α is an important characteristic of BC, it is not its most defining feature. Rather, its hallmark is chromosomal instability and aneuploidy. On the basis of our studies, we developed a new paradigm in a murine breast tumor model induced by near physiological estrogen levels that exquisitely resembles human ductal BC, both in its histopathologic and molecular progression. Estrogen-driven deregulation of the cell cycle and the mitotic machinery are crucial molecular events leading to BC in this estrogen-induced murine mammary tumor model and in women.

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Authors and Affiliations

  1. Hormonal Oncogenesis Laboratory, Department of Pharmacology, Toxicology and Therapeutics,, TheUniversity of KansasMedicalCenter, 3901 RainbowBoulevard, 66160, KansasCity, USA

    Jonathan J. Li & Sara Antonia Li

Authors
  1. Jonathan J. Li
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  2. Sara Antonia Li
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Editor information

Editors and Affiliations

  1. Cedars-Sinai Medical Center, 8700 Beverly Blvd. Room 2015, CA 90048, Los Angeles, USA

    Shlomo Melmed

  2. CRLC Val d’Aurelle Bat B Cancer Research Center, 34298, Monpellier Cedex 5, France

    Henri Rochefort

  3. Service d’Endocrinologie, Hˆopital Bicˆetre, 78, avenue de G´eneral Leclerc, 94275, Kremlin-Bicˆetre, France

    Phillipe Chanson

  4. Pour la Recherche Thérapeutique, Fondation IPSEN, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen

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© 2008 Springer-Verlag Berlin Heidelberg

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Li, J., Li, S. (2008). Deciphering the Conundrum of Estrogen-driven Breast Cancer: Aurora Kinase Deregulation. In: Melmed, S., Rochefort, H., Chanson, P., Christen, Y. (eds) Hormonal Control of Cell Cycle. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73855-8_6

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