Methods to Induce Experimental Obesity
General Considerations
Influence of the central nervous system, in particular of the hypothalamus, on development of obesity has been suspected since the early clinical observations of Babinski (1900) and Fröhlich (1901), Biedl 1916). Experiments reported by Smith (1927, 1930) showed that injections of chromic acid into the suprasellular region of rats with lesion of the hypothalamus induced obesity in rats (Bomskov 1939). Hetherington and Ranson (1939) found that electrolytic lesions, restricted to the ventromedial region of the hypothalamus, could be associated with the development of obesity.
A virally induced obesity syndrome in mice was described by Lyons et al. (1982).
Chan (1995) gave a review on β-cell stimulus‐secretion coupling defects in rodent models of obesity.
Leiter and Herberg (1997) reviewed the advances in understanding the molecular bases for monogenic obesity mutations capable of producing obesity‐induced diabetes, or...
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References and Further Reading
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Vogel, H. (2007). Anti-obesity Activity. In: Vogel, H.G. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70995-4_13
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