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Cell Therapy and Gene Therapy Using Endothelial Progenitor Cells for Vascular Regeneration

  • Chapter
Bone Marrow-Derived Progenitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 180))

Abstract

The isolation of endothelial progenitor cells (EPCs) derived from adult bone marrow (BM) was an epoch-making event for the recognition of “neovessel formation” occurring as physiological and pathological responses in adults. The finding that EPCs home to sites of neovascularization and differentiate into endothelial cells (ECs) in situ is consistent with “vasculogenesis,” a critical paradigm well described for embryonic neovascularization, but proposed recently in adults, in which a reservoir of stem or progenitor cells contributes to vascular organogenesis. EPCs have also been considered as therapeutic agents to supply the potent origin of neovascularization under pathological conditions. Considering the regenerative implications, gene modification of stem cells has advantages over conventional gene therapy. Ex vivo gene transfection of stem cells may avoid administration of vectors and vehicles into the recipient organism. Stem cells isolated from adults may exhibit age-related, genetic, or acquired disease-related impairment of their regenerative ability. Transcriptional or enzymatic gene modification may constitute an effective means to maintain, enhance, or inhibit EPCs’ capacity to proliferate or differentiate. This chapter provides an update of EPC biology as well as EPCs’ potential use for therapeutic regeneration.

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Author information

Authors and Affiliations

  1. Department of Regenerative Medicine Science, Tokai University School of Medicine, 736 Cambridge Street, Brighton, MA, 02135-2997, USA

    T. Asahara

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  1. T. Asahara
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Editor information

Editors and Affiliations

  1. Cardiovascular Disease Boehringer Ingelheim, Pharmaceuticals, Inc., 175 Briar Ridge Road, Ridgefield, CT, 06877, USA

    Katalin Kauser MD, PhD, DSc (Director) (Director)

  2. Department of Internal Medicine III, University of Frankfurt, Theodor-Stern-Kai 7, D-60590, Frankfurt a. Main

    Andreas-Michael Zeiher MD (Professor Molecular Cardiology) (Professor Molecular Cardiology)

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© 2007 Springer-Verlag Berlin Heidelberg

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Asahara, T. (2007). Cell Therapy and Gene Therapy Using Endothelial Progenitor Cells for Vascular Regeneration. In: Kauser, K., Zeiher, AM. (eds) Bone Marrow-Derived Progenitors. Handbook of Experimental Pharmacology, vol 180. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68976-8_8

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