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Corneal Regenerative Medicine: Corneal Substitutes for Transplantation

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Cornea and External Eye Disease

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

Abstract

■ Corneal substitutes are needed to address the shortage of human donor tissues and the current disadvantages in some clinical indications, including immune rejection

■ Substitutes have been designed to replace part of or the full thickness of damaged or diseased corneas. They range from prostheses, known as keratoprostheses (KPros), through naturally fabricated, cell-based, tissue equivalents, to tissue-engineered scaffolds that serve as templates for the regeneration of host tissues

■ At present, widely accepted substitutes are not available although prostheses (KPros) have been in clinical testing or in limited clinical use

■ The trends toward replacement of only damaged portions of the cornea and replacement of the epithelium by corneal limbal cell transplant has been gaining momentum

■ Corneal substitutes that encourage regeneration of the host tissue may likely overcome the rejection problems and other postoperative complications of donor tissue transplantation and KPros

■ There will probably not be a single “onesize- fits-all” corneal substitute for all indications. Instead, a small range of corneal substitutes that are tailored to different clusters of clinical indications will be available

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Authors and Affiliations

  1. The Ottawa Hospital, General Campus, University of Ottawa Eye Institute, 501 Smyth Road, K1H 8L6, Ottawa, Ontario , Canada

    May Griffith, Per Fagerholm, Wenguang Liu, Christopher R. McLaughlin & Fengfu Li

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  1. May Griffith
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  2. Per Fagerholm
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  3. Wenguang Liu
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  4. Christopher R. McLaughlin
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  5. Fengfu Li
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Thomas Reinhard Frank Larkin

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Griffith, M., Fagerholm, P., Liu, W., McLaughlin, C., Li, F. (2008). Corneal Regenerative Medicine: Corneal Substitutes for Transplantation. In: Reinhard, T., Larkin, F. (eds) Cornea and External Eye Disease. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33681-5_3

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  • DOI: https://doi.org/10.1007/978-3-540-33681-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-33680-8

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