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Salivary Gland Transplantation

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Oculoplastics and Orbit

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

In absolute tear deficiency, severe ocular surface damage can progress despite copious use of arti- ficial tear substitutes, resulting in persistent pain and permanent loss of vision [29]. In this situation, mucous membrane grafting alone will not provide sufficient lubrication to alleviate symptoms or to enable successful ocular surface reconstruction. Several studies have demonstrated that oral and nasal mucosa could successfully be used to reconstruct the fornices and provide mucin for lubrication.

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References

  1. Ashley FL, Schwartz AN, Straatsma BR, et al. (1959) Transplantation of the parotid duct for xerophthalmia. Am Surg 25:815–818

    PubMed  CAS  Google Scholar 

  2. Bennett JE (1969) The management of total xerophthalmia. Arch Ophthalmol 81:667–682

    PubMed  CAS  Google Scholar 

  3. Borrelli M, Schröder C, Dart JKG, Collin JRO, Sieg P, Cree IA, Matheson MA, Tiffany JM, Proctor G, van Best J, Hyde N, Geerling G (2007) Long term follow up after submandibular gland transplantation in severe dry eyes secondary to cicatrising conjunctivitis. Ophthalmology (submitted)

    Google Scholar 

  4. Crawford B (1970) Parotid duct transplantation for ocular xerosis. Trans Aust Coll Ophthalmol 2:92–95

    PubMed  CAS  Google Scholar 

  5. Filatov VP, Chevaljev VE (1951) Surgical treatment of parenchymatous ophthalmoxerosis. J Oftalmol (Odessa) 3:131–137

    Google Scholar 

  6. Geerling G, Sieg P, Bastian GO, et al. (1998) Transplantation of the autologous submandibular gland for most severe cases of keratoconjunctivitis sicca. Ophthalmology 105:32–35

    Article  Google Scholar 

  7. Geerling G, Sieg P, Meyer C, et al. (1998) Transplantation der autologen Glandula submandibularis bei schwerster Keratoconjunctivitis sicca – 2-Jahres-Ergebnisse. Ophthalmologe 95:257–265

    Article  PubMed  CAS  Google Scholar 

  8. Geerling G, Honnicke K, Schroder C, et al. (1999) Quality of salivary tears following autologous submandibular gland transplantation for severe dry eye. Graefes Arch Clin Exp Ophthalmol 237:546–553

    Article  PubMed  CAS  Google Scholar 

  9. Geerling G, Daniels JT, Dart JK, et al. (2001) Toxicity of natural tear substitutes in a fully defined culture model of human corneal epithelial cells. Invest Ophthalmol Vis Sci 42:948–956

    PubMed  CAS  Google Scholar 

  10. Geerling G, Liu CSC, Collin JRO, et al. (2002) Costs and gains of complex procedures to rehabilitate end stage ocular surface disease. Br J Ophthalmol 86:1220–1221

    Article  PubMed  CAS  Google Scholar 

  11. Gelatt KN (1991) Canine lacrimal and nasolacrimal diseases. In: Gelatt KN (ed) Veterinary ophthalmology, 2nd edn. Lea & Febiger, London, pp 276–289

    Google Scholar 

  12. Gaubenstock LM (1995) Dental caries and the secretory activity of human labial minor salivary glands. Arch Oral Biol 40:525–528

    Article  PubMed  CAS  Google Scholar 

  13. Guerissi JO, Belmonte J (2004) Surgical treatment of dry eye syndrome: conjunctival graft of the minor salivary gland. J Craniofac Surg 15:6–10

    Article  Google Scholar 

  14. Heiligenhaus A, Shore JW, Rubin PA, Foster CS (1993) Long-term results of mucous membrane grafting in ocular cicatricial pemphigoid. Implications for patient selection and surgical considerations. Ophthalmology 100:1283–1288

    PubMed  CAS  Google Scholar 

  15. Keegan DJ, Geerling G, Lee JP, Blake G, Collin JRO, Plant GT (2002) Botulinum toxin treatment for hyperlacrimation secondary to aberrant regenerated seventh nerve palsy or salivary gland transplantation. Br J Ophthalmol 86:43–46

    Article  PubMed  Google Scholar 

  16. Koski H, Konttinen YT, Hiertanen J, et al. (1997) Epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor in labial salivary glands in Sjögren’s syndrome. J Rheumatol 24:1930–1935

    PubMed  CAS  Google Scholar 

  17. Kuckelkorn R, Schrage N, Redbrake C, Kottek A, Reim M (1996) Autologous transplantation of nasal mucosa after severe chemical and thermal eye burns. Acta Ophthalmol Scand 74:442–448

    Article  PubMed  CAS  Google Scholar 

  18. Kumar PAV, MacLeod AM, O’Brien B, Hickey MJ, Knight KR (1990) Microvascular submandibular gland transfer for the management of xerophthalmia; an experimental study. Br J Plast Surg 43:431–436

    Article  PubMed  CAS  Google Scholar 

  19. Lasudry J (1992) Experimental approach to surgical treatment of lacrimal insufficiency by microvascular submandibular salivary gland autotransplantation. Bull Soc Belge Ophthalmol 245:45–51

    CAS  Google Scholar 

  20. Lauer I, Sieg P, Bahre M, et al. (1998) Salivary gland scintigraphy using technetium-99m-per­technetate after autotransplantation of the submandibular salivary gland in the correction of dry eye. Eur J Nucl Med 25:128–131

    Article  PubMed  CAS  Google Scholar 

  21. MacLeod AM, Robbins SP (1992) Submandibular gland transfer in the correction of dry eye. Aust N Z J Ophthalmol 20:99–103

    PubMed  CAS  Google Scholar 

  22. MacLeod A, Kumar AV, Hertess I, Newing R (1990) Microvascular submandibular gland transfer; an alternative approach for total xerophthalmia. Br J Plast Surg 43:437–439

    Article  PubMed  CAS  Google Scholar 

  23. Murube J (1986) Transplantation of salivary gland to the lacrimal basin. Scand J Rheumatol Suppl 61:264–267

    Google Scholar 

  24. Murube J, Marcos MG, Javate R (1994) Amylase in mare lacrimale in patients with submandibular salivary gland transplantation to the lacrimal basin. Adv Exp Med Biol 350:565–570

    PubMed  CAS  Google Scholar 

  25. Murube J, Manyari A, ChenZhuo L, et al. (1998) Labial salivary gland transplantation in severe dry eye. Oper Tech Oculoplast Orbital Reconstr Surg 1:104–110

    Google Scholar 

  26. Peterson-Jones SM (1997) Quantification of conjunctival sac bacteria in normal dogs and those suffering from keratoconjunctivitis sicca. Vet Comp Ophthalmol 7:29–35

    Google Scholar 

  27. Pierce MK, Goldberg JL, Brooks CJ (1960) A direct approach for transposition of the parotid duct. Arch Ophthalmol 64:566–570

    PubMed  CAS  Google Scholar 

  28. Schroeder C, Sieg P, Framme C, Honnicke K, Hakim SG, Geerling G (2002) [Transplantation of the submandibular gland in absolute dry eyes. Effect on the ocular surface]. Klin Monatsbl Augenheilkd 219:494–501

    Article  Google Scholar 

  29. Schroeder C, Hakim SG, Collin JRO, et al. (2003) [Long-term follow-up after autologous submandibular gland transplantation in scarring keratoconjunctivitis with absolute dry eyes]. Ophthalmologe 100:1079–1084

    Article  Google Scholar 

  30. Sieg P, Geerling G, Kosmehl H, Lauer I, Warnecke K, von Domarus H (2000) Microvascular submandibular gland transfer for severe cases of keratoconjunctivitis sicca. Plast Reconstr Surg 106:554–560

    Article  PubMed  CAS  Google Scholar 

  31. Soares EJ, Franca VP (2005) Transplantation of labial salivary glands for severe dry eye treatment. Arq Bras Oftalmol 68:481–489

    Article  PubMed  Google Scholar 

  32. Wenkel H, Rummelt V, Naumann GOH (1999) Long term results after autologous nasal mucosal transplantation in severe mucus deficiency syndromes. Br J Ophthalmol 84:279–284

    Article  Google Scholar 

  33. Yu GY, Zhu ZH, Mao C, Cai ZG, Zou LH, Lu L, Zhang L, Peng X, Huang NL (2004) Microvascular autologous submandibular gland transfer in severe cases of keratoconjunctivitis sicca. Int J Oral Maxillofac Surg 33:235–239

    Article  PubMed  CAS  Google Scholar 

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Rudolf Guthoff James Katowitz

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© 2007 Springer-Verlag Berlin Heidelberg

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(2007). Salivary Gland Transplantation. In: Guthoff, R., Katowitz, J. (eds) Oculoplastics and Orbit. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33677-8_14

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  • DOI: https://doi.org/10.1007/978-3-540-33677-8_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-33675-4

  • Online ISBN: 978-3-540-33677-8

  • eBook Packages: MedicineMedicine (R0)

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