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Early Breast Cancer (Stage I and II): Tailored Radiotherapy for Very Young Women

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Breast Cancer and Molecular Medicine

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References

  1. Clark, R.M., et al., Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst, 1996. 88(22): p. 1659–64.

    Article  PubMed  CAS  Google Scholar 

  2. Forrest, A.P., et al., Randomised controlled trial of conservation therapy for breast cancer: 6-year analysis of the Scottish trial. Scottish Cancer Trials Breast Group. Lancet, 1996. 348(9029): p. 708–13.

    Article  PubMed  CAS  Google Scholar 

  3. Liljegren, G., et al., 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Clin Oncol, 1999. 17(8): p. 2326–33.

    PubMed  CAS  Google Scholar 

  4. EBCTCG, Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet, 2000. 355(9217): p. 1757–70.

    Article  Google Scholar 

  5. Holli, K., et al., Lumpectomy with or without postoperative radiotherapy for breast cancer with favourable prognostic features: results of a randomized study. Br J Cancer, 2001. 84(2): p. 164–9.

    Article  PubMed  CAS  Google Scholar 

  6. Veronesi, U., et al., Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol, 2001. 12(7): p. 997–1003.

    Article  PubMed  CAS  Google Scholar 

  7. Fisher, B., et al., Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less. J Clin Oncol, 2002. 20(20): p. 4141–9.

    Article  PubMed  CAS  Google Scholar 

  8. Malmstrom, P., et al., Breast conservation surgery, with and without radiotherapy, in women with lymph node-negative breast cancer: a randomised clinical trial in a population with access to public mammography screening. Eur J Cancer, 2003. 39(12): p. 1690–7.

    Article  PubMed  CAS  Google Scholar 

  9. Winzer, K.J., et al., Radiation therapy after breast-conserving surgery; first results of a randomised clinical trial in patients with low risk of recurrence. Eur J Cancer, 2004. 40(7): p. 998–1005.

    Article  PubMed  Google Scholar 

  10. Julien, J.P., et al., Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: first results of the EORTC randomised phase III trial 10853. EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group. Lancet, 2000. 355(9203): p. 528–33.

    Article  PubMed  CAS  Google Scholar 

  11. Fisher, B., et al., Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the national surgical adjuvant breast and bowel project experience. Semin Oncol, 2001. 28(4): p. 400–18.

    Article  PubMed  CAS  Google Scholar 

  12. Houghton, J., et al., Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand: randomised controlled trial. Lancet, 2003. 362(9378): p. 95–102.

    Article  PubMed  Google Scholar 

  13. Vrieling, C., et al., Can patient-, treatment-and pathology-related characteristics explain the high local recurrence rate following breast-conserving therapy in young patients? Eur J Cancer, 2003. 39(7): p. 932–44.

    Article  PubMed  CAS  Google Scholar 

  14. Vicini, F.A. and A. Recht, Age at diagnosis and outcome for women with ductal carcinoma-in-situ of the breast: a critical review of the literature. J Clin Oncol, 2002. 20(11): p. 2736–44.

    Article  PubMed  Google Scholar 

  15. de la Rochefordiere, A., et al., Age as prognostic factor in premenopausal breast carcinoma. Lancet, 1993. 341(8852): p. 1039–43.

    Article  PubMed  Google Scholar 

  16. Clarke, D.H. and A.A. Martinez, Identification of patients who are at high risk for locoregional breast cancer recurrence after conservative surgery and radiotherapy: a review article for surgeons, pathologists, and radiation and medical oncologists. J Clin Oncol, 1992. 10(3): p. 474–83.

    PubMed  CAS  Google Scholar 

  17. Halverson, K.J., et al., Age as a prognostic factor for breast and regional nodal recurrence following breast conserving surgery and irradiation in stage I and II breast cancer. Int J Radiat Oncol Biol Phys, 1993. 27(5): p. 1045–50.

    PubMed  CAS  Google Scholar 

  18. Colleoni, M., et al., Very young women (< 35 years) with operable breast cancer: features of disease at presentation. Ann Oncol, 2002. 13(2): p. 273–9.

    Article  PubMed  CAS  Google Scholar 

  19. Bonnier, P., et al., Age as a prognostic factor in breast cancer: relationship to pathologic and biologic features. Int J Cancer, 1995. 62(2): p. 138–44.

    Article  PubMed  CAS  Google Scholar 

  20. Kollias, J., et al., Early-onset breast cancer—histopathological and prognostic considerations. Br J Cancer, 1997. 75(9): p. 1318–23.

    PubMed  CAS  Google Scholar 

  21. Ford, D., et al., Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet, 1998. 62(3): p. 676–89.

    Article  PubMed  CAS  Google Scholar 

  22. Armes, J.E., et al., The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: a population-based study. Cancer, 1998. 83(11): p. 2335–45.

    Article  PubMed  CAS  Google Scholar 

  23. Freneaux P, et al., Low expression of bcl-2 in Brca1-associated breast cancers. Br J Cancer, 2000. 83(10): p. 1318–1322.

    Article  PubMed  CAS  Google Scholar 

  24. Malone, K.E., et al., Frequency of BRCA1/BRCA2 mutations in a population-based sample of young breast carcinoma cases. Cancer, 2000. 88(6): p. 1393–402.

    Article  PubMed  CAS  Google Scholar 

  25. Loman, N., et al., Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer. J Natl Cancer Inst, 2001. 93(16): p. 1215–23.

    Article  PubMed  CAS  Google Scholar 

  26. Berry DA, et al., BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes. J Clin Oncol, 2002. 20: p. 2701–2712.

    Article  PubMed  CAS  Google Scholar 

  27. Elkhuizen, P.H., et al., Risk factors for local recurrence after breast-conserving therapy for invasive carcinomas: a case-control study of histological factors and alterations in oncogene expression. Int J Radiat Oncol Biol Phys, 1999. 45(1): p. 73–83.

    Article  PubMed  CAS  Google Scholar 

  28. Calle, R., et al., Local control and survival of breast cancer treated by limited surgery followed by irradiation. Int J Radiat Oncol Biol Phys, 1986. 12(6): p. 873–8.

    PubMed  CAS  Google Scholar 

  29. Kurtz, J.M., et al., Mammary recurrences in women younger than forty. Int J Radiat Oncol Biol Phys, 1988. 15(2): p. 271–6.

    Article  PubMed  CAS  Google Scholar 

  30. Matthews, R.H., et al., Prognostic implications of age in breast cancer patients treated with tumorectomy and irradiation or with mastectomy. Int J Radiat Oncol Biol Phys, 1988. 14(4): p. 659–63.

    PubMed  CAS  Google Scholar 

  31. Recht, A., et al., The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy. Int J Radiat Oncol Biol Phys, 1988. 14(1): p. 3–10.

    PubMed  CAS  Google Scholar 

  32. Fourquet, A., et al., Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow-up. Int J Radiat Oncol Biol Phys, 1989. 17(4): p. 719–25.

    PubMed  CAS  Google Scholar 

  33. Boyages, J., et al., Early breast cancer: predictors of breast recurrence for patients treated with conservative surgery and radiation therapy. Radiother Oncol, 1990. 19(1): p. 29–41.

    Article  PubMed  CAS  Google Scholar 

  34. Chen, K.T., et al., Factors affecting local or regional recurrence in breast cancer. J Formos Med Assoc, 1991. 90(10): p. 986–92.

    PubMed  CAS  Google Scholar 

  35. Borger, J., et al., Risk factors in breast-conservation therapy. J Clin Oncol, 1994. 12(4): p. 653–60.

    PubMed  CAS  Google Scholar 

  36. Kim, S.H., et al., Women 35 years of age or younger have higher locoregional relapse rates after undergoing breast conservation therapy. J Am Coll Surg, 1998. 187(1): p. 1–8.

    Article  PubMed  CAS  Google Scholar 

  37. Touboul, E., et al., Local recurrences and distant metastases after breast-conserving surgery and radiation therapy for early breast cancer. Int J Radiat Oncol Biol Phys, 1999. 43(1): p. 25–38.

    PubMed  CAS  Google Scholar 

  38. Arriagada, R., et al., Predictive factors for local recurrence in 2006 patients with surgically resected small breast cancer. Ann Oncol, 2002. 13(9): p. 1404–13.

    Article  PubMed  CAS  Google Scholar 

  39. McBain, C.A., et al., Local recurrence of breast cancer following surgery and radiotherapy: incidence and outcome. Clin Oncol (R Coll Radiol), 2003. 15(1): p. 25–31.

    CAS  Google Scholar 

  40. Bijker, N., et al., Variations in diagnostic and therapeutic procedures in a multicentre, randomized clinical trial (EORTC 10853) investigating breast-conserving treatment for DCIS. European Journal of Surgical Oncology, 2001. 27(2): p. 135–140.

    Article  PubMed  CAS  Google Scholar 

  41. Solin, L.J., et al., Mammographically detected ductal carcinoma in situ of the breast treated with breast-conserving surgery and definitive breast irradiation: long-term outcome and prognostic significance of patient age and margin status. Int J Radiat Oncol Biol Phys, 2001. 50(4): p. 991–1002.

    Article  PubMed  CAS  Google Scholar 

  42. Cutuli, B., et al., Breast-conserving therapy for ductal carcinoma in situ of the breast: the French Cancer Centers’ experience. Int J Radiat Oncol Biol Phys, 2002. 53(4): p. 868–79.

    Article  PubMed  Google Scholar 

  43. Haffty BG, et al., Outcome of conservatively managed early-onset breast cancer by BRCA1/BRCA2 status. Lancet, 2002. 359: p. 1471–1477.

    Article  PubMed  Google Scholar 

  44. Pierce LJ, et al., Effect of radiotherapy after breast-conserving treatment in women with breast cancer and germline BRCA1/2 mutations. J Clin Oncol, 2000. 18: p. 3360–3369.

    PubMed  CAS  Google Scholar 

  45. Robson, M.E., et al., A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment. Breast Cancer Res, 2004. 6(1): p. R8–R17.

    Article  PubMed  CAS  Google Scholar 

  46. Sartor, C.I., Epidermal growth factor family receptors and inhibitors: radiation response modulators. Semin Radiat Oncol, 2003. 13(1): p. 22–30.

    Article  PubMed  Google Scholar 

  47. Haffty, B.G. and P.M. Glazer, Molecular markers in clinical radiation oncology. Oncogene, 2003. 22(37): p. 5915–25.

    Article  PubMed  CAS  Google Scholar 

  48. Willers, H., J. Dahm-Daphi, and S.N. Powell, Repair of radiation damage to DNA. Br J Cancer, 2004. 90(7): p. 1297–301.

    Article  PubMed  CAS  Google Scholar 

  49. Weber-Mangal, S., et al., Breast cancer in young women (< or = 35 years): Genomic aberrations detected by comparative genomic hybridization. Int J Cancer, 2003. 107(4): p. 583–92.

    Article  PubMed  CAS  Google Scholar 

  50. Remvikos, Y., H. Magdelenat, and B. Dutrillaux, Genetic evolution of breast cancers. III: Age-dependent variations in the correlations between biological indicators of prognosis. Breast Cancer Res Treat, 1995. 34(1): p. 25–33.

    Article  PubMed  CAS  Google Scholar 

  51. Bartelink, H., et al., Towards prediction and modulation of treatment response. Radiother Oncol, 1999. 50(1): p. 1–11.

    Article  PubMed  CAS  Google Scholar 

  52. Kreike, B., et al., Gene expression profiling of patients at risk for local recurrence after breast conserving therapy. Eur J Cancer [Abst.], 2004. 2(3): p. 161.

    Google Scholar 

  53. Bartelink H, et al., Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional irradiation. N Engl J Med, 2001. 345(19): p. 1378–1387.

    Article  PubMed  CAS  Google Scholar 

  54. Bataini, J.P., et al., Relation between time-dose and local control of operable breast cancer treated by tumorectomy and radiotherapy or by radical radiotherapy alone. Cancer, 1978. 42(4): p. 2059–65.

    Article  PubMed  CAS  Google Scholar 

  55. Arriagada, R., et al., Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margaret Hospital. Int J Radiat Oncol Biol Phys, 1985. 11(10): p. 1751–7.

    PubMed  CAS  Google Scholar 

  56. Vrieling, C., et al., The influence of the boost in breast-conserving therapy on cosmetic outcome in the EORTC “boost versus no boost” trial. EORTC Radiotherapy and Breast Cancer Cooperative Groups. European Organization for Research and Treatment of Cancer. Int J Radiat Oncol Biol Phys, 1999. 45(3): p. 677–85.

    Article  PubMed  CAS  Google Scholar 

  57. Linderholm, B., et al., Does vascular endothelial growth factor (VEGF) predict local relapse and survival in radiotherapy-treated node-negative breast cancer? Br J Cancer, 1999. 81(4): p. 727–32.

    Article  PubMed  CAS  Google Scholar 

  58. Manders, P., et al., Vascular endothelial growth factor independently predicts the efficacy of postoperative radiotherapy in node-negative breast cancer patients. Clin Cancer Res, 2003. 9(17): p. 6363–70.

    PubMed  CAS  Google Scholar 

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Fourquet, A., Sigal-Zafrani, B., de la Rochefordière, A. (2006). Early Breast Cancer (Stage I and II): Tailored Radiotherapy for Very Young Women. In: Piccart, M.J., Hung, MC., Solin, L.J., Cardoso, F., Wood, W.C. (eds) Breast Cancer and Molecular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-28266-2_14

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  • DOI: https://doi.org/10.1007/978-3-540-28266-2_14

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