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Chronic Kidney Disease (CKD) Clinical Trials: A Critical Appraisal

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Informing Clinical Practice in Nephrology

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Abstract

For the last three decades, and since the publication of the “Hyperperfusion–Hyperfiltration” hypothesis by Brenner and his colleagues in Boston, USA [1], considerable research has focused on the understanding of the pathophysiology of chronic kidney disease (CKD). Numerous additional hypotheses and theories have been published, focusing on the key role of renal as well as extrarenal cells in the pathogenesis of progressive renal scarring and fibrosis and the consequent decline in kidney function witnessed in CKD. These have been followed by a slow transition from the preclinical world of laboratory investigations to the bedside with a number of key clinical trials.

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Acknowledgments

The author acknowledges the contribution made by Swami VJ, Okel J, and Bello AM to an initial version of this chapter.

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Authors and Affiliations

  1. Sheffield Kidney Institute, Global Kidney Academy, Sheffield, S17 3NG, UK

    Meguid El Nahas MD, PhD, FRCP

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  1. Meguid El Nahas MD, PhD, FRCP
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Correspondence to Meguid El Nahas MD, PhD, FRCP .

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Editors and Affiliations

  1. Doncaster Royal Infirmary, Doncaster, United Kingdom

    Mohsen El Kossi

  2. Sheffield Kidney Institute Northern General Hospital, Sheffield, United Kingdom

    Arif Khwaja

  3. Sheffield Kidney Institute Northern General Hospital, Sheffield, United Kingdom

    Meguid El Nahas

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El Nahas, M. (2015). Chronic Kidney Disease (CKD) Clinical Trials: A Critical Appraisal. In: El Kossi, M., Khwaja, A., El Nahas, M. (eds) Informing Clinical Practice in Nephrology. Springer, Cham. https://doi.org/10.1007/978-3-319-10292-4_5

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  • DOI: https://doi.org/10.1007/978-3-319-10292-4_5

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