Abstract
The nucleus is the largest of the cellular compartments, housing the chromosomes with the vast majority of the cellular genome, as well as multiple molecular machineries necessary for gene organisation and expression. During the past years contemporarily with the successful sequencing of the entire human genome, knowledge of nuclear architectures has also enormously increased and exciting results provide evidence that the longstanding dogma of a spatial separation of gene transcription in the nucleus and translation in the cytoplasm cannot be maintained.
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References
Cremer T and Cremer C (2001) Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat Rev Genetics 2: 292
Iborra FJ, Jackson DA, and Cook PR (2001) Coupled transcription and translation within nuclei of mammalian cells. Science 293: 1139
Lamond AI and Spector DL (2003) Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol 4: 605
Misteli T (2008) Physiological importance of RNA and protein mobility in the cell nucleus. Histochem Cell Biol 129: 5
Pederson T (2002) Dynamics and genome-centricity of interchromatin domains in the nucleus. Nat Cell Biol 4: E287
Roix J and Misteli T (2002) Genomes, proteoms, and dynamic networks in the cell nucleus. Histochem Cell Biol 118: 105
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Pavelka, M., Roth, J. (2010). Architecture of the Cell Nucleus. In: Functional Ultrastructure. Springer, Vienna. https://doi.org/10.1007/978-3-211-99390-3_2
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DOI: https://doi.org/10.1007/978-3-211-99390-3_2
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-99389-7
Online ISBN: 978-3-211-99390-3
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