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Infection, autoimmunity and autoimmune disease

  • Chapter
Stress-Inducible Cellular Responses

Part of the book series: EXS ((EXS,volume 77))

Abstract

Studies of the immune response of mammals to infectious agents have revealed that members of the hsp60 and hsp70 family are highly immunodominant. Given their high conservation during evolution this was surprising, because of the apparent risk of triggering of autoimmunity and autoimmune disease during the defense of a mammal against infection. However, detailed studies of the immune responses to HSP in models of autoimmune diseases in animals resulted in a change of the view that autoimmunity necessarily leads to autoimmune disease. It has been found that modulation of autoimmunity to HSP is one way to prevent autoimmune disease. At least in some cases even treatment of autoimmune diseases by immunization with heat shock protein appears feasible. This was shown in adjuvant arthritis in Lewis rats and insulin dependent diabetes in NOD mice. Hsp60 and hsp70 are ubiquitous proteins. Their involvement in regulatory loops of autoimmunity may serve as basis for the development of strategies to prevent and/or treat autoimmune diseases even without knowledge of the causative (auto-)antigen.

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Authors and Affiliations

  1. Department of Pharmacology, AMGEN Center, Thousand Oaks, CA, USA

    U. Feige

  2. Department of Immunology, Faculty of Veterinary Medicine, University of Utrecht, NL-3508, TD, Utrecht, Netherlands

    W. van Eden

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  1. U. Feige
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  2. W. van Eden
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, AMGEN Center, 1840 De Havilland Drive, 15-2-A-224, 91320-1789, Thousand Oaks, CA, USA

    U. Feige

  2. Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-Ku, Tokyo 113, Japan

    I. Yahara

  3. Department of Biochemistry, Molecular and Cell Biology Northwestern University, 2153 Sheridan Road, 60208-3500, Evanston, IL, USA

    R. I. Morimoto

  4. Laboratoire de Physiologie Respiratoire, Université Paris 5 UFR Cochin Port-Royal, 24, rue du Faubourg Saint-Jacques, F-75014, Paris, France

    B. S. Polla

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Feige, U., van Eden, W. (1996). Infection, autoimmunity and autoimmune disease. In: Feige, U., Yahara, I., Morimoto, R.I., Polla, B.S. (eds) Stress-Inducible Cellular Responses. EXS, vol 77. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9088-5_24

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  • DOI: https://doi.org/10.1007/978-3-0348-9088-5_24

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