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Adipose Tissue Inflammation in Obesity

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Physiology and Physiopathology of Adipose Tissue

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Abstract

Low-grade inflammation both at the systemic level and in the adipose tissue characterizes obesity. Among the different cell types contributing to adipose tissue inflammation, macrophages play a central role. The number and the phenotype of macrophages change in response to fat mass variations. A newly discovered local consequence of adipose tissue inflammation is fibrosis. How these immuno-inflammatory abnormalities link adipose tissue enlargement to obesity cardiometabolic co-morbidities is discussed in this chapter.

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Authors and Affiliations

  1. Institut des maladies cardiométaboliques et de la nutrition (IHU ICAN), Paris, France

    Christine Poitou, Elise Dalmas & Karine Clément

  2. Nutriomique U872 équipe 7, Centre de recherche des Cordeliers, INSERM, UPMC, 15, rue de l’école de médecine, 75006, Paris, France

    Christine Poitou, Elise Dalmas & Karine Clément

  3. Centre de Recherche en Nutrition Humaine Ile-de-France (CRNH IdF),  , Paris, France

    Christine Poitou & Karine Clément

  4. Assistance Publique Hôpitaux de Paris, Service de Nutrition, Bâtiment Benjamin Delessert, Hôpital Pitié-Salpêtrière, 91 boulevard de L’hôpital, 75013, Paris, France

    Christine Poitou & Karine Clément

Authors
  1. Christine Poitou
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  2. Elise Dalmas
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  3. Karine Clément
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Correspondence to Christine Poitou .

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Editors and Affiliations

  1. Rue de la Chine 4, Paris, 75020, France

    Jean-Philippe Bastard

  2. Hôpital Saint-Antoine, Paris, France

    Bruno Fève

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Poitou, C., Dalmas, E., Clément, K. (2013). Adipose Tissue Inflammation in Obesity. In: Bastard, JP., Fève, B. (eds) Physiology and Physiopathology of Adipose Tissue. Springer, Paris. https://doi.org/10.1007/978-2-8178-0343-2_20

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  • DOI: https://doi.org/10.1007/978-2-8178-0343-2_20

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  • Print ISBN: 978-2-8178-0342-5

  • Online ISBN: 978-2-8178-0343-2

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