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Parkinsonism Plus Syndromes

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Neurodegenerative Disorders

Abstract

Parkinson’s plus syndrome is a term that refers to disorders of movement and cognition that are often confused with Parkinson’s disease. The three main disorders are progressive supranuclear palsy (PSP), multisystem atrophy (MSA), and corticobasal degeneration (CBD). These syndromes are pathologically diverse encompassing a number of distinct proteinopathies but have in common clinical features of movement abnormality, cognitive decline, a more rapid clinical course than Parkinson’s disease, and a generally poor therapeutic response to levodopa. The diagnosis is largely clinical with some reliable radiological features. Therapy is largely in the realm of multidisciplinary symptomatic support but advances in molecular and biological understanding is leading to exciting therapeutic avenues.

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Further Reading

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Author information

Authors and Affiliations

  1. Department of Neurosciences, Royal College of Surgeons in Ireland Medical School, Dublin, Ireland

    Daniel G. Healy

Authors
  1. Fiona M. Molloy
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  2. Daniel G. Healy
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Corresponding author

Correspondence to Daniel G. Healy .

Editor information

Editors and Affiliations

  1. Beaumont Hospital, Dublin 9, D9, Ireland

    Orla Hardiman

  2. St James Hospital, Dublin, D2, Ireland

    Colin P. Doherty

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© 2011 Springer-Verlag London Limited

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Molloy, F.M., Healy, D.G. (2011). Parkinsonism Plus Syndromes. In: Hardiman, O., Doherty, C. (eds) Neurodegenerative Disorders. Springer, London. https://doi.org/10.1007/978-1-84996-011-3_9

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  • DOI: https://doi.org/10.1007/978-1-84996-011-3_9

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84996-010-6

  • Online ISBN: 978-1-84996-011-3

  • eBook Packages: MedicineMedicine (R0)

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