Summary
Vascular birthmarks are a common cutaneous finding in newborns and infants. Characterization of these vascular anomalies is challenging and the terminology has historically been confusing. A classification system was proposed by Mulliken and Glowacki and modified by the International Society for the Study of Vascular Anomalies in 1996 to help clarify this confusion. It separates vascular anomalies into two distinct categories, tumors and vascular malformations, based on clinical appearance, natural history, and pathologic characteristics. The term hemangioma is reserved for congenital vascular tumors, while vascular malformations include a variety of lesions with varying clinical presentations. Proper identification and classification of these lesions have important implications in their management and treatment.
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Abbreviations
- AVM:
-
Arteriovenous malformations
- BRBN:
-
Blue rubber bleb nevus
- CM:
-
Capillary malformations
- CMTC:
-
Cutis marmorata telangiectatica congenital
- GVM:
-
Glomuvenous malformations
- ISSVA:
-
International Society for the Study of Vascular Anomalies
- KTS:
-
Klippel—Trenaunay syndrome
- LM:
-
Lymphatic malformation
- NICH:
-
Noninvoluting congenital heman-giomas
- PWS:
-
Port wine stains
- PHACES:
-
Posterior fossa, Hemangioma, Arterial, Cardiac defect, Coarctation of the aorta, Eye anomaly, Sternal clefting, or Supraumbilical raphe
- PDL:
-
Pulsed dye laser
- RICH:
-
Rapidly Involuting Congenital Hemangiomas
- SWS:
-
Sturge—Weber syndrome
- VM:
-
Venous malformations
References
Ashinoff R, Geronemus RJ. Flashlamp-pumped pulsed dye laser for port-wine stains in infancy: earlier versus later treatment. J Am Acad Dermatol. 1991;24:467–472.
Amitai DB, Fichman S, Merlob P, Morad Y, Lapidoth M, Metzker A. Cutis marmorata telangiectatica congenita: clinical findings in 85 patients. Pediatr Dermatol. 2000;17:100–104.
Bauland CG, van Steensel MA, Steijlen PM, Rieu PN, Spauwen PH. The pathogenesis of hemangiomas: a review. Plast Reconstr Surg. 2006;117:29e–35e.
Bennett ML, Fleischer AB Jr, Chamlin SL, Frieden IJ. Oral corticosteroid use is effective for cutaneous heman-giomas: an evidence-based evaluation. Arch Dermatol. 2001;137:1208–1213.
Biesecker LG, Happle R, Mulliken JB, et al. Proteus syndrome: diagnostic criteria, differential diagnosis, and patient evaluation. Am J Med Genet. 1999;84:389–395.
Blei F, Walter J, Orlow SJ, Marchuk DA. Familial segregation of hemangimas and vascular malformations as an autosomal dominant trait. Arch Dermatol. 1998;134:718–722.
Bloom DC, Perkins JA, Manning SC. Management of lymphatic malformations. Curr Opin Otolaryngol Head Neck Surg. 2004;131:784–786.
Boon LM, Mulliken JB, Enjolras O, Vikkula M. Glomuvenous malformation (glomangioma) and venous malformation. Distinct clinicopathologic and genetic entities. Arch Dermatol. 2004;140:971–976.
Bruckner AL, Frieden IJ. Hemangiomas of infancy. J Am Acad Dermatol. 2003;48:477–493.
Burton BK, Schulz CJ, Angle B, Burd LI. An increased incidence of haemangiomas in infants born following chorionic villus sampling (CVS). Prenat Diagn. 1995;15:209–214.
Ceisler EJ, Santos L, Blei F. Periocular hemangiomas: what every physician should know. Pediatr Dermatol. 2004;21:1–9
Chamlin SL, Haggstrom AN, Drolet BA, et al. Multicenter prospective study of ulcerated hemangiomas. J Pediatr. 2007;151:684–689.
Darmstadt GL. Perianal lymphangioma circumscriptum mistaken for genital warts. Pediatrics. 1996;98:461–463.
Dubois J, Garel L. Imaging and therapeutic approach of hemangiomas and vascular malformationsin the pediat-ric age group. Pediatr Radiol. 1999;29:879–893.
Enjolras O, Mulliken JB. Vascular tumors and vascular malformations (new issues). Adv Dermatol. 1997;13:375–423.
Finn MC, Glowacki J, Mulliken JB. Congenital vascular lesions: clinical application of a new classification. J Pediatr Surg. 1983;18:894–900
Frieden IJ, Eichenfield LF, Esterly NB, Geronemus R, Mallory SB. Guidelines of care for hemangiomas of infancy. American Academy of Dermatology Guidelines/ Outcomes Committee. J Am Acad Dermatol. 1997;37:631–637
Garzon MC, Huang JT, Enjolras O, Frieden IJ. Vascular malformations (Part I). J Am Acad Dermatol. 2007;56:353–370
Garzon MC, Huang JT, Enjolras O, Frieden IJ. Vascular malformations (Part II: Associated syndromes). J Am Acad Dermatol. 2007;56:541–564
Garzon MC, Lucky AW, Hawrot A, Frieden IJ. Ultrapotent topical corticosteroid treatment of hemangiomas of infancy. J Am Acad Dermatol. 2005;52:281–286.
Goldberg NS, Hebert AA, Esterly NB. Sacral heman-giomas and multiple congenital abnormalities. Arch Dermatol. 1986;122:684–687.
Hancock BJ, St-Vil D, Luks F, Di Lorenzo M, Blanchard H. Complications of lymphangiomas in children. J Pediatr Surg. 1992;27:220–224.
Hemangioma Investigator Group, Haggstrom AN, Drolet BA, Baselga E, et al. Prospective study of infantile heman-giomas: demographic, prenatal, and perinatal characteristics. J Pediatr. 2007;150:291–294.
Higuera S, Gordley K, Metry DW, Stal S. Management of hemangiomas and pediatric vascular malformations. J Craniofac Surg. 2006;17:783–789.
Ho NT, Lansang P, Pope E. Topical imiquimod in the treatment of infantile hemangiomas: a retrospective study. J Am Acad Dermatol. 2007;56:63–68.
Huang SA, Tu HM, Harney JW, et al. Severe hypo-thryoidism caused by type 3 iodothryronine deiodinase in infantile hemangiomas. N Engl J Med. 2000;343:185–189.
Jasim ZF, Handley JM. Treatment of pulsed dye laser-resistant port wine stain birthmarks. J Am Acad Dermatol. 2007;57:677–682.
Kohout MP, Hansen M, Pribaz JJ, Mulliken JB. Arterio-venous malformations of the head and neck: natural history and management. Plast Reconstr Surg. 1998;102:643–654.
Krol A, MacArthur CJ. Congenital hemangiomas: rapidly involuting and noninvoluting congenital hemangiomas. Arch Facial Plast Surg. 2005;7:307–311.
Lopriore E, Markhorst DG. Diffuse neonatal heman-giomatosis: new views on diagnostic criteria and prognosis. Acta Paediatr. 1999;88:93–97.
Maari C, Frieden IJ. Klippel-Trénaunay syndrome: the importance of “geographic stains” in identifying lymphatic disease and risk of complications. J Am Acad Dermatol. 2004;51:391–398.
Maguiness S, Guenther L. Kasabach—Merritt syndrome. J Cutan Med Surg. 2002;6:335–359.
Mazereeuw-Hautier J, Syed S, Harper J. Bilateral facial capillary malformation associated with eye and brain abnormalities. Arch Dermatol. 2006;142:994–998.
McAlvany JP, Jorizzo JL, Zanolli D, et al. Magnetic resonance imaging in the evaluation of lymphangioma circumscriptum. Arch Dermatol. 1993;129:194–197.
Metry DW. Potential complications of segmental heman-giomas of infancy. Semin Cutan Med Surg. 2004;23:107–115.
Metry DW, Dowd CF, Barkovich AJ, Frieden IJ. The many faces of PHACE syndrome. J Pediatr. 2001;139:117–123.
Metry DW, Haggstrom AN. Drolet BA, et al. A prospective study of PHACE syndrome in infantile hemangiomas: demographic features, clinical findings, and complications. Am J Med Genet A. 2006;140:975–986.
Metz BJ, Rubenstein MC, Levy ML, Metry DW. Response of ulcerated perineal hemangiomas of infancy to becaplermin gel, a recombinant human platelet-derived growth factor. Arch Dermatol. 2004;140:867–870.
Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982;69:412–422.
Paller AS. The Sturge-Weber syndrome. Pediatr Dermatol. 1987;4:300–304.
Peachey RD, Lim CC, Whimster IW. Lymphangioma of skin. A review of 65 cases. Br J Dermatol. 1970;83:519–527.
Powell TG, West CR, Pharoah PO, Cooke RW. Epidemiology of strawberry haemangioma in low birthweight infants. Br J Dermatol. 1987;116:635–641.
Railan D, Parlette EC, Uebelhoer NS, Rohrer TE. Laser treatment of vascular lesions. Clin Dermatol. 2006;24:8–15.
Puig S, Aref H, Chigot V, Bonin B, Brunelle F. Classification of venous malformations in children and implications for sclerotherapy. Pediatr Radiol. 2003;33:99–103.
Renfro L, Geronemus RG. Anatomic differences of port-wine stains in response to treatment with the pulsed dye laser. Arch Dermatol. 1993;129:182–188.
Seccia A, Salgarello M, Farallo E, Falappa PG. Combined radiological and surgical treatment of arteriovenous malformations of the head and neck. Ann Plast Surg. 1999;43:359–366.
Tallman B, Tan OT, Morelli JG, et al. Location of port-wine stains and the liklihood of ophthalmic and/or central nervous system complications. Pediatrics. 1991;87:323–327.
Tubbs RS, Wellons JC 3rd, Iskandar BJ, Oakes WJ. Isolated flat capillary midline lumbosacral hemangiomas as indicators of occult spinal dysraphism. J Neurosurg. 2004;100(2 Suppl Pediatrics):86–89.
Turner JT, Cohen MM Jr, Biesecker LG. Reassessment of the Proteus syndrome literature: application of diagnostic criteria to published cases. Am J Med Genet. 2004;130:111–122.
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Lucas, J., Gasbarre, C., Vidimos, A.T. (2010). Congenital Malformations. In: Siemionow, M.Z., Eisenmann-Klein, M. (eds) Plastic and Reconstructive Surgery. Springer Specialist Surgery Series. Springer, London. https://doi.org/10.1007/978-1-84882-513-0_14
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