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Pulmonary Endothelial Control of the Pulmonary Microcirculation

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Congenital Diseases in the Right Heart
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References

  1. Rabinovitch M, Haworth SG, Castaneda AR, et al. Lung biopsy in congenital heart disease: a morphometric approach to pulmonary vascular disease. Circulation. Dec 1978;58(6):1107–22.

    PubMed  CAS  Google Scholar 

  2. Burrows FA, Klinck JR, Rabinovitch M, et al. Pulmonary hypertension in children: perioperative management. Can Anaesth Soc J. Sep 1986;33(5):606–28.

    PubMed  CAS  Google Scholar 

  3. Hoffman JI, Rudolph AM, Heymann MA. Pulmonary vascular disease with congenital heart lesions: pathologic features and causes. Circulation. Nov 1981;64(5):873–7.

    PubMed  CAS  Google Scholar 

  4. Wheller J, George BL, Mulder DG, et al. Diagnosis and management of postoperative pulmonary hypertensive crisis. Circulation. Dec 1979;60(7):1640–44.

    PubMed  CAS  Google Scholar 

  5. Bush PA, Gonzalez NE, Ignarro LJ. Biosynthesis of nitric oxide and citrulline from l-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. Biochem Biophys Res Commun. Jul 15 1992;186(1):308–14.

    Article  PubMed  CAS  Google Scholar 

  6. Ignarro LJ, Byrns RE, Buga GM, et al. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res. Dec 1987;61(6):866–79.

    PubMed  CAS  Google Scholar 

  7. Ignarro LJ, Ross G, Tillisch J. Pharmacology of endothelium-derived nitric oxide and nitrovasodilators. West J Med. Jan 1991;154(1):51–62.

    PubMed  CAS  Google Scholar 

  8. Sessa WC, Harrison JK, Luthin DR, et al. Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase. Hypertension. Jun 1993;21(6 Pt 2):934–38.

    PubMed  CAS  Google Scholar 

  9. Lamas S, Marsden PA, Li GK, et al. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A. Jul 15 1992;89(14):6348–52.

    Article  PubMed  CAS  Google Scholar 

  10. Lyons CR, Orloff GJ, Cunningham JM. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. Mar 25 1992;267(9):6370–74.

    PubMed  CAS  Google Scholar 

  11. Ignarro LJ, Harbison RG, Wood KS, et al. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J Pharmacol Exp Ther. Jun 1986;237(3):893–900.

    PubMed  CAS  Google Scholar 

  12. Murad F. Cyclic guanosine monophosphate as a mediator of vasodilation. J Clin Invest. Jul 1986;78(1):1–5.

    Article  PubMed  CAS  Google Scholar 

  13. Mulsch A, Bassenge E, Busse R. Nitric oxide synthesis in endothelial cytosol: evidence for a calcium-dependent and a calcium-independent mechanism. Naunyn Schmiedebergs Arch Pharmacol. Dec 1989;340(6 Pt 2):767–70.

    PubMed  CAS  Google Scholar 

  14. Rubanyi GM, Romero JC, Vanhoutte PM. Flow-induced release of endothelium-derived relaxing factor. Am J Physiol. Jun 1986;250(6 Pt 2):H1145–49.

    PubMed  CAS  Google Scholar 

  15. Papapetropoulos A, Rudic RD, Sessa WC. Molecular control of nitric oxide synthases in the cardiovascular system. Cardiovasc Res. Aug 15 1999;43(3):509–20.

    Article  PubMed  CAS  Google Scholar 

  16. Fleming I, Busse R. Signal transduction of eNOS activation. Cardiovasc Res. Aug 15 1999;43(3):532–41.

    Article  PubMed  CAS  Google Scholar 

  17. Andrew PJ, Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc Res. Aug 15 1999;43(3):521–31.

    Article  PubMed  CAS  Google Scholar 

  18. Govers R, Rabelink TJ. Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol. Feb 2001;280(2):F193–206.

    PubMed  CAS  Google Scholar 

  19. Ziegler T, Silacci P, Harrison VJ, et al. Nitric oxide synthase expression in endothelial cells exposed to mechanical forces. Hypertension. Aug 1998;32(2):351–55.

    PubMed  CAS  Google Scholar 

  20. Searles CD, Miwa Y, Harrison DG, et al. Posttranscriptional regulation of endothelial nitric oxide synthase during cell growth. Circ Res. Oct 1 1999;85(7):588–95.

    PubMed  CAS  Google Scholar 

  21. Shaul PW. Regulation of endothelial nitric oxide synthase: location, location, location. Annu Rev Physiol. 2002;64:749–74.

    Article  PubMed  CAS  Google Scholar 

  22. Fulton D, Gratton JP, Sessa WC. Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough? J Pharmacol Exp Ther. Dec 2001;299(3):818–24.

    PubMed  CAS  Google Scholar 

  23. Pritchard KA Jr, Ackerman AW, Gross ER, et al. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. J Biol Chem. May 25 2001;276(21):17621–24.

    Article  PubMed  CAS  Google Scholar 

  24. Johnson LR, Rush JW, Turk JR, et al. Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries. J Appl Physiol. Mar 2001;90(3):1102–10.

    Article  PubMed  CAS  Google Scholar 

  25. Ohno M, Gibbons GH, Dzau VJ, et al. Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. Circulation. 1993;88(1):193–97.

    PubMed  CAS  Google Scholar 

  26. Corson MA, James NL, Latta SE, et al. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res. 1996;79(5):984–91.

    PubMed  CAS  Google Scholar 

  27. Malek AM, Izumo S, Alper SL. Modulation by pathophysiological stimuli of the shear stress-induced up-regulation of endothelial nitric oxide synthase expression in endothelial cells. Neurosurgery. 1999;45(2):334–44; discussion 344–35.

    Article  PubMed  CAS  Google Scholar 

  28. Brashers VL, Peach MJ, Rose CE Jr. Augmentation of hypoxic pulmonary vasoconstriction in the isolated perfused rat lung by in vitro antagonists of endothelium-dependent relaxation. J Clin Invest. Nov 1988;82(5):1495–502.

    Article  PubMed  CAS  Google Scholar 

  29. Fineman JR, Soifer SJ, Heymann MA. Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol. 1995;57:115–34.

    Article  PubMed  CAS  Google Scholar 

  30. Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med. Jul 27 1995;333(4):214–21.

    Article  PubMed  CAS  Google Scholar 

  31. Black SM, Bekker JM, McMullan DM, et al. Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow. Pediatr Res. Aug 2002;52(2):233–44.

    PubMed  CAS  Google Scholar 

  32. Black SM, Fineman JR, Steinhorn RH, et al. Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol. Nov 1998;275(5 Pt 2):H1643–51.

    PubMed  CAS  Google Scholar 

  33. Fineman JR, Chang R, Soifer SJ. EDRF inhibition augments pulmonary hypertension in intact newborn lambs. Am J Physiol. May 1992;262(5 Pt 2):H1365–71.

    PubMed  CAS  Google Scholar 

  34. Fineman JR, Crowley MR, Heymann MA, et al. In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue. J Appl Physiol. Aug 1991;71(2):735–41.

    PubMed  CAS  Google Scholar 

  35. Fineman JR, Wong J, Mikhailov T, et al. Altered endothelial function in lambs with pulmonary hypertension and acute lung injury. Pediatr Pulmonol. Mar 1999;27(3):147–56.

    Article  PubMed  CAS  Google Scholar 

  36. Reddy VM, Wong J, Liddicoat JR, et al. Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. Aug 1996;271(2 Pt 2):H562–70.

    PubMed  CAS  Google Scholar 

  37. Steinhorn RH, Fineman JR. The pathophysiology of pulmonary hypertension in congenital heart disease. Artif Organs. Nov 1999;23(11):970–74.

    Article  PubMed  CAS  Google Scholar 

  38. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. Mar 31 1988;332(6163):411–15.

    Article  PubMed  CAS  Google Scholar 

  39. Shimada K, Takahashi M, Ikeda M, et al. Identification and characterization of two isoforms of an endothelin-converting enzyme-1. FEBS Lett. Sep 4 1995;371(2):140–4.

    Article  PubMed  CAS  Google Scholar 

  40. Bradley LM, Czaja JF, Goldstein RE. Circulatory effects of endothelin in newborn piglets. Am J Physiol. Nov 1990;259(5 Pt 2):H1613–17.

    PubMed  CAS  Google Scholar 

  41. Cassin S, Kristova V, Davis T, et al. Tone-dependent responses to endothelin in the isolated perfused fetal sheep pulmonary circulation in situ. J Appl Physiol. Mar 1991;70(3):1228–34.

    PubMed  CAS  Google Scholar 

  42. Wong J, Vanderford PA, Fineman JR, et al. Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. Am J Physiol. Oct 1993;265(4 Pt 2):H1318–25.

    PubMed  CAS  Google Scholar 

  43. Wong J, Vanderford PA, Fineman JR, et al. Developmental effects of endothelin-1 on the pulmonary circulation in sheep. Pediatr Res. Sep 1994;36(3):394–401.

    Article  PubMed  CAS  Google Scholar 

  44. Perreault T, De Marte J. Maturational changes in endothelium-derived relaxations in newborn piglet pulmonary circulation. Am J Physiol. Feb 1993;264(2 Pt 2):H302–309.

    PubMed  CAS  Google Scholar 

  45. Arai H, Hori S, Aramori I, et al. Cloning and expression of a cDNA encoding an endothelin receptor. Nature. Dec 20–27 1990;348(6303):730–32.

    Article  PubMed  CAS  Google Scholar 

  46. Sakurai T, Yanagisawa M, Takuwa Y, et al. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature. Dec 20–27 1990;348(6303):732–35.

    Article  PubMed  CAS  Google Scholar 

  47. Shetty SS, Okada T, Webb RL, et al. Functionally distinct endothelin B receptors in vascular endothelium and smooth muscle. Biochem Biophys Res Commun. Mar 15 1993;191(2):459–64.

    Article  PubMed  CAS  Google Scholar 

  48. Wong J, Vanderford PA, Winters J, et al. Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension. J Cardiovasc Pharmacol. Feb 1995;25(2):207–15.

    Article  PubMed  CAS  Google Scholar 

  49. La M, Reid JJ. Endothelin-1 and the regulation of vascular tone. Clin Exp Pharmacol Physiol. May 1995;22(5):315–23.

    Article  PubMed  CAS  Google Scholar 

  50. Steffan M, Russell JA. Signal transduction in endothelin-induced contraction of rabbit pulmonary vein. Pulm Pharmacol. 1990;3(1):1–7.

    Article  PubMed  CAS  Google Scholar 

  51. Russell JA, Roberts JM. Functional antagonism in rabbit pulmonary veins contracted by endothelin. Pulm Pharmacol. 1991;4(2):67–72.

    Article  PubMed  CAS  Google Scholar 

  52. Fagan KA, McMurtry IF, Rodman DM. Role of endothelin-1 in lung disease. Respir Res. 2001;2(2):90–101.

    Article  PubMed  CAS  Google Scholar 

  53. Kurihara H, Yoshizumi M, Sugiyama T, et al. Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells. Biochem Biophys Res Commun. Mar 31 1989;159(3):1435–40.

    Article  PubMed  CAS  Google Scholar 

  54. Imai T, Hirata Y, Emori T, et al. Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells. Hypertension. Jun 1992;19(6 Pt 2):753–7.

    PubMed  CAS  Google Scholar 

  55. Marsden PA, Brenner BM. Transcriptional regulation of the endothelin-1 gene by TNF-alpha. Am J Physiol. Apr 1992;262(4 Pt 1):C854–61.

    PubMed  CAS  Google Scholar 

  56. Miyauchi T, Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol. 1999;61:391–415.

    Article  PubMed  CAS  Google Scholar 

  57. Matsuura A, Kawashima S, Yamochi W, et al. Vascular endothelial growth factor increases endothelin-converting enzyme expression in vascular endothelial cells. Biochem Biophys Res Commun. Jun 27 1997;235(3):713–6.

    Article  PubMed  CAS  Google Scholar 

  58. Minamino T, Kurihara H, Takahashi M, et al. Endothelin-converting enzyme expression in the rat vascular injury model and human coronary atherosclerosis. Circulation. Jan 7 1997;95(1):221–30.

    PubMed  CAS  Google Scholar 

  59. Teerlink JR, Loffler BM, Hess P, et al. Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan). Circulation. Nov 1994;90(5):2510–18.

    PubMed  CAS  Google Scholar 

  60. Mitsutomi N, Akashi C, Odagiri J, et al. Effects of endogenous and exogenous nitric oxide on endothelin-1 production in cultured vascular endothelial cells. Eur J Pharmacol. Jan 1 1999;364(1):65–73.

    Article  PubMed  CAS  Google Scholar 

  61. Fukuroda T, Fujikawa T, Ozaki S, et al. Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem Biophys Res Commun. Mar 30 1994;199(3):1461–65.

    Article  PubMed  CAS  Google Scholar 

  62. Kuchan MJ, Frangos JA. Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells. Am J Physiol. Jan 1993;264(1 Pt 2):H150–56.

    PubMed  CAS  Google Scholar 

  63. Macarthur H, Warner TD, Wood EG, et al. Endothelin-1 release from endothelial cells in culture is elevated both acutely and chronically by short periods of mechanical stretch. Biochem Biophys Res Commun. Apr 15 1994;200(1):395–400.

    Article  PubMed  CAS  Google Scholar 

  64. Morawietz H, Talanow R, Szibor M, et al. Regulation of the endothelin system by shear stress in human endothelial cells. J Physiol. Jun 15 2000;525 Pt 3:761–70.

    Article  PubMed  CAS  Google Scholar 

  65. Harrison VJ, Ziegler T, Bouzourene K, et al. Endothelin-1 and endothelin-converting enzyme-1 gene regulation by shear stress and flow-induced pressure. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S38–41.

    Article  PubMed  CAS  Google Scholar 

  66. Masatsugu K, Itoh H, Chun TH, et al. Physiologic shear stress suppresses endothelin-converting enzyme-1 expression in vascular endothelial cells. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S42–5.

    Article  PubMed  CAS  Google Scholar 

  67. Ziegler T, Bouzourene K, Harrison VJ, et al. Influence of oscillatory and unidirectional flow environments on the expression of endothelin and nitric oxide synthase in cultured endothelial cells. Arterioscler Thromb Vasc Biol. May 1998;18(5):686–92.

    PubMed  CAS  Google Scholar 

  68. Dschietzig T, Richter C, Bartsch C, et al. Flow-induced pressure differentially regulates endothelin-1, urotensin II, adrenomedullin, and relaxin in pulmonary vascular endothelium. Biochem Biophys Res Commun. Nov 23 2001;289(1):245–51.

    Article  PubMed  CAS  Google Scholar 

  69. Ohtsuka S. Changes of vasoactive peptides and effects of inhaled nitric oxide after pneumonectomy. Kurume Med J. 1996;43(4):295–304.

    PubMed  CAS  Google Scholar 

  70. Cruden NL, Newby DE, Ross JA, et al. Effect of cold exposure, exercise and high altitude on plasma endothelin-1 and endothelial cell markers in man. Scott Med J. Oct 1999;44(5):143–6.

    PubMed  CAS  Google Scholar 

  71. Lenz T, Nadansky M, Gossmann J, et al. Exhaustive exercise-induced tissue hypoxia does not change endothelin and big endothelin plasma levels in normal volunteers. Am J Hypertens. Aug 1998;11(8 Pt 1):1028–31.

    Article  PubMed  CAS  Google Scholar 

  72. Maeda S, Miyauchi T, Sakai S, et al. Prolonged exercise causes an increase in endothelin-1 production in the heart in rats. Am J Physiol. Dec 1998;275(6 Pt 2):H2105–112.

    PubMed  CAS  Google Scholar 

  73. Lauth M, Berger MM, Cattaruzza M, et al. Elevated perfusion pressure upregulates endothelin-1 and endothelin B receptor expression in the rabbit carotid artery. Hypertension. Feb 2000;35(2):648–54.

    PubMed  CAS  Google Scholar 

  74. Wedgwood S, Dettman R, Black S. ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1058–67.

    PubMed  CAS  Google Scholar 

  75. Christman BW, McPherson CD, Newman JH, et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med. Jul 9 1992;327(2):70–5.

    PubMed  CAS  Google Scholar 

  76. Giaid A, Yanagisawa M, Langleben D, et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med. Jun 17 1993;328(24):1732–39.

    Article  PubMed  CAS  Google Scholar 

  77. Celermajer DS, Cullen S, Deanfield JE. Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation. Feb 1993;87(2):440–6.

    PubMed  CAS  Google Scholar 

  78. Cacoub P, Dorent R, Nataf P, et al. Plasma endothelin and pulmonary pressures in patients with congestive heart failure. Am Heart J. Dec 1993;126(6):1484–8.

    Article  PubMed  CAS  Google Scholar 

  79. Bolger AP, Sharma R, Li W, et al. Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease. Circulation. Jul 2 2002;106(1):92–9.

    Article  PubMed  CAS  Google Scholar 

  80. Yoshibayashi M, Nishioka K, Nakao K, et al. Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation. Circulation. Dec 1991;84(6):2280–5.

    PubMed  CAS  Google Scholar 

  81. Cacoub P, Dorent R, Nataf P, et al. Endothelin-1 in pulmonary hypertension. N Engl J Med. Dec 23 1993;329(26):1967–8.

    Article  PubMed  CAS  Google Scholar 

  82. Ovadia B, Reinhartz O, Fitzgerald R, et al. Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. Feb 2003;284(2):H480–90.

    PubMed  CAS  Google Scholar 

  83. Grobe AC, Wells SM, Benavidez E, et al. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol. Jun 2006;290(6):L1069–77.

    Article  PubMed  CAS  Google Scholar 

  84. Black SM, Mata-Greenwood E, Dettman RW, et al. Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow. Circulation. Sep 30 2003;108(13):1646–54.

    Article  PubMed  CAS  Google Scholar 

  85. Bauer M, Wilkens H, Langer F, et al. Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension. Circulation. Mar 5 2002;105(9):1034–36.

    Article  PubMed  CAS  Google Scholar 

  86. Day RW, Allen EM, Witte MK. A randomized, controlled study of the 1-hour and 24-hour effects of inhaled nitric oxide therapy in children with acute hypoxemic respiratory failure. Chest. Nov 5 1997;112(5):1324–31.

    Article  PubMed  CAS  Google Scholar 

  87. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. The Neonatal Inhaled Nitric Oxide Study Group. N Engl J Med. Feb 27 1997;336(9):597–604.

    Article  Google Scholar 

  88. Atz AM, Wessel DL. Inhaled nitric oxide in the neonate with cardiac disease. Semin Perinatol. Oct 1997;21(5):441–55.

    Article  PubMed  CAS  Google Scholar 

  89. Clark RH, Kueser TJ, Walker MW, et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N Engl J Med. Feb 17 2000;342(7):469–74.

    Article  PubMed  CAS  Google Scholar 

  90. Dellinger RP, Zimmerman JL, Taylor RW, et al. Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med. Jan 1998;26(1):15–23.

    Article  PubMed  CAS  Google Scholar 

  91. Dobyns EL, Cornfield DN, Anas NG, et al. Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure. J Pediatr. Apr 1999;134(4):406–12.

    Article  PubMed  CAS  Google Scholar 

  92. Fineman JR, Zwass MS. Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn. Acta Paediatr Jpn. Aug 1995;37(4):425–30.

    PubMed  CAS  Google Scholar 

  93. Karamanoukian HL, Glick PL, Zayek M, et al. Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios. Pediatrics. Nov 1994;94(5):715–18.

    PubMed  CAS  Google Scholar 

  94. Kinsella JP, Truog WE, Walsh WF, et al. Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. J Pediatr. Jul 1997;131(1 Pt 1):55–62.

    PubMed  CAS  Google Scholar 

  95. Lunn RJ. Inhaled nitric oxide therapy. Mayo Clin Proc. Mar 1995;70(3):247–55.

    PubMed  CAS  Google Scholar 

  96. Roberts JD, Jr., Fineman JR, Morin FC, 3rd, et al. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med. Feb 27 1997;336(9):605–610.

    Article  PubMed  CAS  Google Scholar 

  97. Russell IA, Zwass MS, Fineman JR, et al. The effects of inhaled nitric oxide on postoperative pulmonary hypertension in infants and children undergoing surgical repair of congenital heart disease. Anesth Analg. Jul 1998;87(1):46–51.

    Article  PubMed  CAS  Google Scholar 

  98. Schreiber MD, Gin-Mestan K, Marks JD, et al. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med. Nov 27 2003;349(22):2099–107.

    Article  PubMed  CAS  Google Scholar 

  99. De Wet CJ, Affleck DG, Jacobsohn E, et al. Inhaled prostacyclin is safe, effective, and affordable in patients with pulmonary hypertension, right heart dysfunction, and refractory hypoxemia after cardiothoracic surgery. J Thorac Cardiovasc Surg. Apr 2004;127(4):1058–67.

    Article  PubMed  CAS  Google Scholar 

  100. Hache M, Denault A, Belisle S, et al. Inhaled epoprostenol (prostacyclin) and pulmonary hypertension before cardiac surgery. J Thorac Cardiovasc Surg. Mar 2003;125(3):642–9.

    Article  PubMed  CAS  Google Scholar 

  101. Kelly LK, Porta NF, Goodman DM, et al. Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide. J Pediatr. Dec 2002;141(6):830–32.

    Article  PubMed  CAS  Google Scholar 

  102. Weston MW, Isaac BF, Crain C. The use of inhaled prostacyclin in nitroprusside-resistant pulmonary artery hypertension. J Heart Lung Transplant. Dec 2001;20(12):1340–44.

    Article  PubMed  CAS  Google Scholar 

  103. Hache M, Denault AY, Belisle S, et al. Inhaled prostacyclin (PGI2) is an effective addition to the treatment of pulmonary hypertension and hypoxia in the operating room and intensive care unit. Can J Anaesth. Oct 2001;48(9):924–9.

    Article  PubMed  CAS  Google Scholar 

  104. Fiser SM, Cope JT, Kron IL, et al. Aerosolized prostacyclin (epoprostenol) as an alternative to inhaled nitric oxide for patients with reperfusion injury after lung transplantation. J Thorac Cardiovasc Surg. May 2001;121(5):981–2.

    Article  PubMed  CAS  Google Scholar 

  105. Della Rocca G, Coccia C, Costa MG, et al. Inhaled areosolized prostacyclin and pulmonary hypertension during anesthesia for lung transplantation. Transplant Proc. Feb–Mar 2001;33(1–2):1634–36.

    Article  PubMed  CAS  Google Scholar 

  106. Abe Y, Tatsumi K, Sugito K, et al. Effects of inhaled prostacyclin analogue on chronic hypoxic pulmonary hypertension. J Cardiovasc Pharmacol. Mar 2001;37(3):239–51.

    Article  PubMed  CAS  Google Scholar 

  107. van Heerden PV, Barden A, Michalopoulos N, et al. Dose-response to inhaled aerosolized prostacyclin for hypoxemia due to ARDS. Chest. Mar 2000;117(3):819–27.

    Article  PubMed  Google Scholar 

  108. Max M, Rossaint R. Inhaled prostacyclin in the treatment of pulmonary hypertension. Eur J Pediatr. Dec 1999;158 Suppl 1:S23–26.

    Article  PubMed  CAS  Google Scholar 

  109. Olschewski H, Ghofrani HA, Walmrath D, et al. Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis. Am J Respir Crit Care Med. Aug 1999;160(2):600–607.

    PubMed  CAS  Google Scholar 

  110. Beavo JA. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev. Oct 1995;75(4):725–48.

    PubMed  CAS  Google Scholar 

  111. Torphy TJ, Zhou HL, Burman M, et al. Role of cyclic nucleotide phosphodiesterase isozymes in intact canine trachealis. Mol Pharmacol. Mar 1991;39(3):376–84.

    PubMed  CAS  Google Scholar 

  112. Thomas MK, Francis SH, Corbin JD. Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase. J Biol Chem. Sep 5 1990;265(25):14964–70.

    PubMed  CAS  Google Scholar 

  113. Watanabe H, Ohashi K, Takeuchi K, et al. Sildenafil for primary and secondary pulmonary hypertension. Clin Pharmacol Ther. May 2002;71(5):398–402.

    Article  PubMed  Google Scholar 

  114. Humpl T, Reyes JT, Holtby H, et al. Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: twelve-month clinical trial of a single-drug, open-label, pilot study. Circulation. Jun 21 2005;111(24):3274–30.

    Article  PubMed  CAS  Google Scholar 

  115. Shekerdemian LS, Ravn HB, Penny DJ. Interaction between inhaled nitric oxide and intravenous sildenafil in a porcine model of meconium aspiration syndrome. Pediatr Res. Mar 2004;55(3):413–18.

    Article  PubMed  CAS  Google Scholar 

  116. Stocker C, Penny DJ, Brizard CP, et al. Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery. Intensive Care Med. Nov 2003;29(11):1996–2003.

    Article  PubMed  Google Scholar 

  117. Faraci FM, Heistad DD. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev. Jan 1998;78(1):53–97.

    PubMed  CAS  Google Scholar 

  118. Rosenberg AA, Kennaugh J, Koppenhafer SL, et al. Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension. J Pediatr. Jul 1993;123(1):109–14.

    Article  PubMed  CAS  Google Scholar 

  119. Wong J, Reddy VM, Hendricks-Munoz K, et al. Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol. Dec 1995;269(6 Pt 2):H1965–72.

    PubMed  CAS  Google Scholar 

  120. Channick RN, Simonneau G, Sitbon O, et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet. Oct 6 2001;358(9288):1119–23.

    Article  PubMed  CAS  Google Scholar 

  121. Rubin LJ, Badesch DB, Barst RJ, et al. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med. Mar 21 2002;346(12):896–903.

    Article  PubMed  CAS  Google Scholar 

  122. Morris CR, Morris SM, Jr., Hagar W, et al. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med. Jul 1 2003;168(1):63–9.

    Article  PubMed  Google Scholar 

  123. Morris CR. New strategies for the treatment of pulmonary hypertension in sickle cell disease : the rationale for arginine tTherapy. Treat Respir Med. 2006;5(1):31–45.

    Article  PubMed  CAS  Google Scholar 

  124. Morris CR, Kato GJ, Poljakovic M, et al. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. Jama. Jul 6 2005;294(1):81–90.

    Article  PubMed  CAS  Google Scholar 

  125. Lopez BL, Kreshak AA, Morris CR, et al. L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department. Br J Haematol. Feb 2003;120(3):532–34.

    Article  PubMed  CAS  Google Scholar 

  126. Morris CR, Kuypers FA, Larkin S, et al. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. J Pediatr Hematol Oncol. Nov–Dec 2000;22(6):515–20.

    Article  PubMed  CAS  Google Scholar 

  127. Morris CR, Kuypers FA, Larkin S, et al. Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease. Br J Haematol. Nov 2000;111(2):498–500.

    Article  PubMed  CAS  Google Scholar 

  128. Steinhorn RH, Albert G, Swartz DD, et al. Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension. Am J Respir Crit Care Med. Sep 1 2001;164(5):834–39.

    PubMed  CAS  Google Scholar 

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Oishi, P., Fineman, J.R. (2009). Pulmonary Endothelial Control of the Pulmonary Microcirculation. In: Redington, A.N., Van Arsdell, G.S., Anderson, R.H. (eds) Congenital Diseases in the Right Heart. Springer, London. https://doi.org/10.1007/978-1-84800-378-1_4

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