Abstract
There have been many books published about the design, conduct, and analysis of clinical trials. Why are osteoporosis trials a special case that deserve a book of their own? There are three main reasons. First, most diseases have a well-understood definition and aetiology. Osteoporosis is a disease that is understood by those working within the subspecialty, but currently there is no definition that is agreeable to both medical and scientific communities and its aetiology is poorly understood. It is within this framework that the pharmaceutical industry is trying to develop new treatments for the so-called “silent epidemic”.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Christiansen, C. (1993). Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 94:646–50.
National Institutes of Health Consensus Development Conference Statement: Osteoporosis Prevention, Diagnosis, and Therapy March 27–29, 2000 (http://consensus.nih.gov/2000/2000Osteoporosis111html.htm accessed 13/11/06).
Kanis, J.A. (1994). Assessment of Fracture Risk and its Application to Screening for Postmenopausal Osteoporosis. Report of a WHO Study Group. Geneva: World Health Organization.
Kanis, J.A. and Gluer, C.C. (2000). An update on the diagnosis and assessment of osteoporosis with densitometry. Committee of Scientific Advisors, International Osteoporosis Foundation. Osteoporos Int 11:192–202.
Selby, P.L., Davies, M. and Adams, J.E. (2000). Do men and women fracture bones at similar bone densities? Osteoporos Int 11:153–7.
Recommendations Guiding Medical Doctors in Biomedical Research Involving Human Subjects. Adopted by the 18th World Medical Assembly, Helsinki, Finland, 1964, and revised by the 52nd World Medical Assembly, Edinburgh, Scotland, 2000 (http://www.wma.net/e/policy/b3.htm accessed 13/11/06).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer-Verlag London Limited
About this chapter
Cite this chapter
Miller, C.G., Pearson, D. (2007). Introduction. In: Pearson, D., Miller, C.G. (eds) Clinical Trials in Osteoporosis. Clinical Trials. Springer, London. https://doi.org/10.1007/978-1-84628-587-5_1
Download citation
DOI: https://doi.org/10.1007/978-1-84628-587-5_1
Publisher Name: Springer, London
Print ISBN: 978-1-84628-389-5
Online ISBN: 978-1-84628-587-5
eBook Packages: MedicineMedicine (R0)