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TRPM6 and TRPM7 Chanzymes Essential for Magnesium Homeostasis

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New Perspectives in Magnesium Research

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Abstract

Mg2+ is the second most abundant intracellular cation and plays an essential role as cofactor in many enzymatic reactions. Regulation of the total body Mg2+ balance principally resides within the kidney that tightly matches the intestinal absorption of Mg2+. The identification of epithelial Mg2+ transporters in the kidney has been greatly facilitated by studying hereditary disorders with primary hypomagnesemia. Identification of the gene defect in hypomagnesemia with secondary hypocalcemia has recently elucidated the TRPM6 protein, a member of the transient receptor potential melastatin (TRPM) family. TRPM6 shows the highest homology with TRPM7, which has been identified as a Mg2+-permeable ion channel primarily required for cellular Mg2+ homeostasis. TRPM6 and TRPM7 are distinct from all other ion channels b ecause t hey are composed of a channel linked to a protein kinase domain and therefore referred to as chanzymes. These chanzymes are essential for Mg2+ homeostasis, which is critical for human health and cell viability. This chapter d escribes the characteristics of epithelial Mg2+ transport in general and highlights the distinctive features and the physiological relevance of these new chanzymes in (patho)physiological situations.

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Author information

Authors and Affiliations

  1. Department of Physiology, Radboud University Nijmegen Medical Centre Nijmegen Centre for Dalccular Life Sciences (NCMTS), Nijmegen, the Netherlands

    Wouter M. Tiel Groenestege

  2. Department of Physiology, Radboud University Nijmegen Redical Centre Nijmegen Centre for Ralcular Life Scicuces (NCMLS), Nijmegen, the Netherlands

    Joost G. J. Hoenderop

  3. Department of Physiology, Radboud Univesity Nijmegen Medical Centre Nijmegen Centre for Molecular Life Sciences (NCMLS), The Netherlands, Nijmegen

    René J. M. Bindels PhD

Authors
  1. Wouter M. Tiel Groenestege
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  2. Joost G. J. Hoenderop
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  3. René J. M. Bindels PhD
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Editor information

Editors and Affiliations

  1. Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan

    Yoshiki Nishizawa MD, PhD (Dean of Medicine, Professor of Internal Medicine) (Dean of Medicine, Professor of Internal Medicine)

  2. Osaka City University, Osaka, Japan

    Hirotoshi Morii MD, PhD (Emeritus Professor) (Emeritus Professor)

  3. Université Pierre et Marie Curie, Paris, France

    Jean Durlach MD, PhD (President of the International Society for the Development of Research on Magnesium (SDRM), Editor-in-Chief Magnesium Research journal) (President of the International Society for the Development of Research on Magnesium (SDRM), Editor-in-Chief Magnesium Research journal)

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© 2007 Springer-Verlag London Limited

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Tiel Groenestege, W.M., Hoenderop, J.G.J., Bindels, R.J.M. (2007). TRPM6 and TRPM7 Chanzymes Essential for Magnesium Homeostasis. In: Nishizawa, Y., Morii, H., Durlach, J. (eds) New Perspectives in Magnesium Research. Springer, London. https://doi.org/10.1007/978-1-84628-483-0_4

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  • DOI: https://doi.org/10.1007/978-1-84628-483-0_4

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-388-8

  • Online ISBN: 978-1-84628-483-0

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