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Tissue-Protective Cytokines: Structure and Evolution

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Tissue-Protective Cytokines

Part of the book series: Methods in Molecular Biology ((MIMB,volume 982))

Abstract

Cytokines are important mediators of host defense and immunity, and were first identified for their role in immunity to infections. It was then found that some of them are pathogenic mediators in inflammatory diseases and much of the emphasis is now on pro-inflammatory cytokines, also in consideration of the fact that TNF inhibitors became effective drugs in chronic inflammatory diseases. The recent studies on the tissue-protective activities of erythropoietin (EPO) led to the term “tissue-protective cytokine.” We discuss here how tissue-protective actions might be common to other cytokines, particularly those of the 4-alpha helical structural superfamily.

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Acknowledgments

Supported by the European Regional Development Fund, Trans-Channel Neuroscience Network to P.G.

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Authors and Affiliations

  1. Brighton & Sussex Medical School, Falmer, UK

    Pietro Ghezzi

  2. Department of Computer Science and Artificial Intelligence, University of the Basque Country UPV/EHU, San Sebastián, Spain

    Darrell Conklin

  3. IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

    Darrell Conklin

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  1. Pietro Ghezzi
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  2. Darrell Conklin
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Editors and Affiliations

  1. Medical School, Brighton and Sussex, Trafford Centre, Falmer, BN1 9RY, United Kingdom

    Pietro Ghezzi

  2. Leiden University Medical Center, Stille Rijn 11a, Leiden, 2312 DE, Netherlands

    Anthony Cerami

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Ghezzi, P., Conklin, D. (2013). Tissue-Protective Cytokines: Structure and Evolution. In: Ghezzi, P., Cerami, A. (eds) Tissue-Protective Cytokines. Methods in Molecular Biology, vol 982. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-308-4_3

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  • DOI: https://doi.org/10.1007/978-1-62703-308-4_3

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  • Publisher Name: Humana Press, Totowa, NJ

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  • Online ISBN: 978-1-62703-308-4

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