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Skeletal Muscle Dysfunction

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Chronic Obstructive Pulmonary Disease

Part of the book series: Respiratory Medicine ((RM))

Abstract

Chronic obstructive pulmonary disease (COPD) is highly prevalent and the burden of this disease is only expected to increase in the coming 15–20 years. Once viewed as a disease limited to the lung, COPD is now recognized as a multisystemic disease with various organ dysfunctions. Skeletal muscle dysfunction is one of the most devastating systemic manifestations of COPD. Skeletal muscle dysfunction is such a reality in COPD that, depending on the clinical situations, 20–35% of the patients refer to leg fatigue as the main cause of exercise cessation, whereas 41% consider it to be at least a major contributor to exercise limitation.

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  1. Department of Respirology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC, Canada

    Marc-André Caron, Marie-Eve Thériault, Richard Debigaré & François Maltais

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  1. Marc-André Caron
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  2. Marie-Eve Thériault
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  3. Richard Debigaré
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  4. François Maltais
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Correspondence to Marc-André Caron .

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  1. Providence Veterans Affairs Medical Cent, Chief, Pulmonary and Critical Care, The Warren Alpert School of Medicine, Chalkstone Ave. 830, Providence, 02908, Rhode Island, USA

    Linda Nici

  2. St. Francis Hospital and Medical Center, Associate Chief, Pulmonary and Critical, University of Connecticut School of Medi, Woodland St. 114, Hartford, 06105, Connecticut, USA

    Richard ZuWallack

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Caron, MA., Thériault, ME., Debigaré, R., Maltais, F. (2012). Skeletal Muscle Dysfunction. In: Nici, L., ZuWallack, R. (eds) Chronic Obstructive Pulmonary Disease. Respiratory Medicine. Humana Press. https://doi.org/10.1007/978-1-60761-673-3_9

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