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CLC-3 Chloride Channels in the Pulmonary Vasculature

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Membrane Receptors, Channels and Transporters in Pulmonary Circulation

Part of the book series: Advances in Experimental Medicine and Biology ((volume 661))

Abstract Volume-sensitive outwardly rectifying anion channels (VSOACs) are expressed in pulmonary artery smooth muscle cells (PASMCs) and have been implicated in cell proliferation, growth, apoptosis and protection against oxidative stress. In this chapter, we review the properties of native VSOACs in PASMCs, and consider the evidence that ClC-3, a member of the ClC superfamily of voltage dependent Cl- channels, may be responsible for native VSOACs in PASMCs. Finally, we examine whether or not native VSOACs and heterologously expressed ClC-3 channels function as bona fide chloride channels or as chloride/proton antiporters.

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Acknowledgments

Our work was supported by National Institutes of Health grants HL-49254 and P20RR1581 from the National Center for Research Resources.

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Authors and Affiliations

  1. Department of Pharmacology, Center of Biomedical Research Excellence, University of Nevada School of Medicine, Reno, NV, 89557, USA

    Joseph R. Hume, Ge-Xin Wang, Lih Chyuan Ng & Dayue Duan

  2. Department of Physiological Sciences and Molecular Biology, Fukuoka Dental College, Fukuoka, Japan

    Jun Yamazaki

Authors
  1. Joseph R. Hume
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  2. Ge-Xin Wang
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  3. Jun Yamazaki
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  4. Lih Chyuan Ng
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  5. Dayue Duan
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Corresponding author

Correspondence to Joseph R. Hume .

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Editors and Affiliations

  1. Departments of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, 60612, USA

    Jason X. -J. Yuan

  2. Guy’s Hospital Campus, Dept. Physiology, King’s College London, London, SE1 1UL, United Kingdom

    Jeremy P. T. Ward

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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Hume, J.R., Wang, GX., Yamazaki, J., Ng, L.C., Duan, D. (2010). CLC-3 Chloride Channels in the Pulmonary Vasculature. In: Yuan, JJ., Ward, J. (eds) Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Advances in Experimental Medicine and Biology, vol 661. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-500-2_15

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