Skip to main content

Factitious Diarrhea

  • Chapter
  • First Online:
Diarrhea

Part of the book series: Clinical Gastroenterology ((CG))

  • 2034 Accesses

Summary

Factitious diarrhea is an intentionally self-inflicted disorder which is motivated either internally by assuming a sick role or externally by money, health benefits, etc. The keys to diagnosis are suspicion and use of readily available stool and urine tests. Since factitious diarrhea is not uncommon and many tests used to evaluate chronic diarrhea are invasive and expensive, it is reasonable to perform a series of basic studies to evaluate for factitious diarrhea early in such an evaluation. Surreptitious laxative use is the most common etiology of factitious diarrhea and can present with volume depletion and an altered biochemical profile. Magnesium-containing laxatives will cause osmotic diarrhea; a high stool osmolar gap and stool magnesium level of more than 90 Meq/L will be present. Stimulant laxatives may cause non-gap diarrhea and can easily be detected in the urine. Any osmolality less than normal (290 mOsmol/kg) indicates dilutional diarrhea, usually the addition of urine or water to stool. All cases of factitious diarrhea should be well documented in the medical record to avoid future unnecessary testing.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. American Psychiatric Association. American Psychiatric Association. Task Force on DSM-IV. Diagnostic and statistical manual of mental disorders: DSM-IV, 4th edn. Washington DC: American Psychiatric Association, 1994.

    Google Scholar 

  2. Savino AC, Fordtran JS. Factitious disease: clinical lessons from case studies at Baylor University Medical Center. Proc Bayl Univ Med Cent 2006; 19(3): 195–208.

    PubMed  Google Scholar 

  3. Phillips SF. Surreptitious laxative abuse: keep it in mind. Semin Gastrointest Dis 1999; 10(4):132–137.

    PubMed  CAS  Google Scholar 

  4. Phillips S, Donaldson L, Geisler K, Pera A, Kochar R. Stool composition in factitial diarrhea: a 6-year experience with stool analysis. Ann Intern Med 1995; 123(2):97–100.

    PubMed  CAS  Google Scholar 

  5. Duncan A, Cameron A, Stewart MJ, Russell RI. Diagnosis of the abuse of magnesium and stimulant laxatives. Ann Clin Biochem 1991; 28(Pt 6):568–573.

    PubMed  Google Scholar 

  6. Keswani RN, Sauk J, Kane SV. Factitious diarrhea masquerading as refractory celiac disease. South Med J 2006; 99(3):293–295.

    Article  PubMed  Google Scholar 

  7. Pollok RC, Banks MR, Fairclough PD, Farthing MJ. Dilutional diarrhoea: under-diagnosed and over-investigated. Eur J Gastroenterol Hepatol 2000; 12(6): 609–611.

    Article  PubMed  CAS  Google Scholar 

  8. Duncan A, Forrest JA. Surreptitious abuse of magnesium laxatives as a cause of chronic diarrhoea. Eur J Gastroenterol Hepatol 2001; 13(5):599–601.

    Article  PubMed  CAS  Google Scholar 

  9. Ewe K, Karbach U. Factitious diarrhoea. Clin Gastroenterol 1986; 15(3):723–740.

    PubMed  CAS  Google Scholar 

  10. Bytzer P, Stokholm M, Andersen I, Klitgaard NA, Schaffalitzky de Muckadell OB. Prevalence of surreptitious laxative abuse in patients with diarrhoea of uncertain origin: a cost benefit analysis of a screening procedure. Gut 1989; 30(10): 1379–1384.

    Article  PubMed  CAS  Google Scholar 

  11. Santangelo WC, Richey JE, Rivera L, Fordtran JS. Surreptitious ipecac administration simulating intestinal pseudo-obstruction. Ann Intern Med 1989; 110(12): 1031–1032.

    PubMed  CAS  Google Scholar 

  12. Schiller LR, Santa Ana CA, Porter J, Fordtran JS. Validation of polyethylene glycol 3350 as a poorly absorbable marker for intestinal perfusion studies. Dig Dis Sci 1997; 42(1):1–5.

    Article  PubMed  CAS  Google Scholar 

  13. Ryan CM, Yarmush ML, Tompkins RG. Separation and quantitation of polyethylene glycols 400 and 3350 from human urine by high-performance liquid chromatography. J Pharm Sci 1992; 81(4):350–352.

    Article  PubMed  CAS  Google Scholar 

  14. Shelton JH, Santa Ana CA, Thompson DR, Emmett M, Fordtran JS. Factitious diarrhea induced by stimulant laxatives: accuracy of diagnosis by a clinical reference laboratory using thin layer chromatography. Clin Chem 2007; 53(1):85–90.

    Article  PubMed  CAS  Google Scholar 

  15. Beyer J, Peters FT, Maurer HH. Screening procedure for detection of stimulant laxatives and/or their metabolites in human urine using gas chromatography-mass spectrometry after enzymatic cleavage of conjugates and extractive methylation. Ther Drug Monit 2005; 27(2):151–157.

    Article  PubMed  CAS  Google Scholar 

  16. Kotha P, Rake MO, Willatt D. Liver damage induced by oxyphenisatin. Br Med J 1980; 281(6254):1530.

    Article  PubMed  CAS  Google Scholar 

  17. Zimmer KP, Marquardt T, Schmitt GM. More on factitious diarrhea. J Pediatr Gastroenterol Nutr 2002; 35(4):584–585.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Roberson, E.N., Wald, A. (2010). Factitious Diarrhea. In: Guandalini, S., Vaziri, H. (eds) Diarrhea. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-183-7_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-60761-183-7_17

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-182-0

  • Online ISBN: 978-1-60761-183-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics