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Pathophysiology and Mechanisms Whereby Hypertension May Cause Stroke

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Hypertension and Stroke

Part of the book series: Clinical Hypertension and Vascular Diseases ((CHVD))

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Abstract

Hypertension is the most important modifiable risk factor for stroke. The degree of elevation of blood pressure is tightly correlated with the risk of stroke. The risk curve is a continuum without any clear point separating the stroke-prone from the non-stroke-prone subjects (1–3). Hypertension plays a key role in the pathogenesis of large artery atherosclerosis, which in turn causes ischemic stroke due to thrombotic arterial occlusion, artery-to-artery embolism, or a combination of these factors. The association between hypertension and lacunar infarct is well established.

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Authors and Affiliations

  1. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China

    Jinhao Han MD, PhD

  2. Department of Neurology, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

    Hee-Joon Bae MD, PhD

  3. Departments of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China

    Lawrence K.S. Wong MD

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  1. Jinhao Han MD, PhD
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  2. Hee-Joon Bae MD, PhD
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  3. Lawrence K.S. Wong MD
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Correspondence to Jinhao Han MD, PhD .

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Editors and Affiliations

  1. College of Medicine, Dept. Neurology, University of Illinois, 912 S. Wood Street Room 855 N, Chicago, 60612, Illinois, USA

    Venkatesh Aiyagari

  2. University of Illinois, Department of Neurology and Rehabilitati, College of Medicine at Chicago, S. Wood St 912, Chicago, 60612, Illinois, USA

    Philip B. Gorelick

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Han, J., Bae, HJ., Wong, L.K. (2011). Pathophysiology and Mechanisms Whereby Hypertension May Cause Stroke. In: Aiyagari, V., Gorelick, P. (eds) Hypertension and Stroke. Clinical Hypertension and Vascular Diseases. Humana Press. https://doi.org/10.1007/978-1-60761-010-6_5

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  • DOI: https://doi.org/10.1007/978-1-60761-010-6_5

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