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Glutamate Plasticity in an Animal Model of Parkinson’s Disease

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Cortico-Subcortical Dynamics in Parkinson's Disease

Part of the book series: Contemporary Neuroscience ((CNEURO))

Although it is well established that in Parkinson’s disease there is a significant loss of dopamine within nerve terminals in the striatum, the depletion of dopamine most likely influences other neurotransmitter systems. There is growing interest in the interactions between dopamine and glutamate and it may be the lack of dopamine in Parkinson’s disease that results in dynamic changes in glutamate within at least the striatum [1, 2]. In the rodent, the sensorimotor cortex provides the primary excitatory, glutamatergic input to the dorsolateral striatum [3, 4], although recent data suggest that glutamate input from many nuclei within the thalamus may also be playing an important role [5–7]. The dopamine terminals originating from the substantia nigra pars compacta (SN-PC) make a symmetrical synaptic contact not only on the dendritic shaft of the medium spiny neuron but also on the neck of the dendritic spine [8, 9]. The asymmetrical synaptic contact on the head of that same spine within the dorsolateral striatum originates from not only the motor cortex but also the thalamus [5, 7] and the nerve terminals contain the neurotransmitter, glutamate [8, 10, 11]

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Reference

  1. Starr MS. Glutamate/dopamine D1/D2 balance in the basal ganglia and its relevance to Parkinson's disease. Synapse 1995;19(4):264–93.

    Article  PubMed  CAS  Google Scholar 

  2. Starr MS. Antiparkinsonian actions of glutamate antagonists--alone and with L-DOPA: a review of evidence and suggestions for possible mechanisms. J Neural Transm Park Dis Dement Sect 1995;10(2–3):141–85.

    PubMed  CAS  Google Scholar 

  3. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J Neurochem 1984;42(1):1–11.

    Article  PubMed  CAS  Google Scholar 

  4. McGeorge AJ, Faull RL. The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 1989;29(3):503–37.

    Article  PubMed  CAS  Google Scholar 

  5. Lacey CJ, Boyes J, Gerlach O, Chen L, Magill PJ, Bolam JP. GABA(B) receptors at glutamatergic synapses in the rat striatum. Neuroscience 2005;136(4):1083–95.

    Article  PubMed  CAS  Google Scholar 

  6. Raju DV, Shah DJ, Wright TM, Hall RA, Smith Y. Differential synaptology of vGluT2-containing thalamostriatal afferents between the patch and matrix compartments in rats. J Comp Neurol 2006;499(2):231–43.

    Article  PubMed  CAS  Google Scholar 

  7. Smith Y, Raju DV, Pare JF, Sidibe M. The thalamostriatal system: a highly specific network of the basal ganglia circuitry. Trends Neurosci 2004;27(9):520–7.

    Article  PubMed  CAS  Google Scholar 

  8. Bouyer JJ, Park DH, Joh TH, Pickel VM. Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum. Brain Res 1984;302(2):267–75.

    Article  PubMed  CAS  Google Scholar 

  9. Freund TF, Powell JF, Smith AD. Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines. Neuroscience 1984;13(4):1189–215.

    Article  PubMed  CAS  Google Scholar 

  10. Gundersen V, Ottersen OP, Storm-Mathisen J. Selective excitatory amino acid uptake in glutamatergic nerve terminals and in glia in the rat striatum: quantitative electron microscopic immunocytochemistry of exogenous (D)-aspartate and endogenous glutamate and GABA. Eur J Neurosci 1996;8(4):758–65.

    Article  PubMed  CAS  Google Scholar 

  11. Meshul CK, Stallbaumer RK, Taylor B, Janowsky A. Haloperidol-induced morphological changes in striatum are associated with glutamate synapses. Brain Res 1994;648(2):181–95.

    Article  PubMed  CAS  Google Scholar 

  12. Bamford NS, Robinson S, Palmiter RD, Joyce JA, Moore C, Meshul CK. Dopamine modulates release from corticostriatal terminals. J Neurosci 2004;24(43):9541–52.

    Article  PubMed  CAS  Google Scholar 

  13. Morari M, O'Connor WT, Ungerstedt U, Fuxe K. Dopamine D1 and D2 receptor antagonism differentially modulates stimulation of striatal neurotransmitter levels by N-methyl-D-aspartic acid. Eur J Pharmacol 1994;256(1):23–30.

    Article  PubMed  CAS  Google Scholar 

  14. Yamamoto BK, Davy S. Dopaminergic modulation of glutamate release in striatum as measured by microdialysis. J Neurochem 1992;58(5):1736–42.

    Article  PubMed  CAS  Google Scholar 

  15. Zhang H, Sulzer D. Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors. J Neurosci 2003;23(33):10585–92.

    PubMed  CAS  Google Scholar 

  16. Sesack SR, Aoki C, Pickel VM. Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets. J Neurosci 1994;14(1):88–106.

    PubMed  CAS  Google Scholar 

  17. Wang H, Pickel VM. Dopamine D2 receptors are present in prefrontal cortical afferents and their targets in patches of the rat caudate-putamen nucleus. J Comp Neurol 2002;442(4):392–404.

    Article  PubMed  CAS  Google Scholar 

  18. Calabresi P, De Murtas M, Mercuri NB, Bernardi G. Chronic neuroleptic treatment: D2 dopamine receptor supersensitivity and striatal glutamatergic transmission. Ann Neurol 1992;31(4):366–73.

    Article  PubMed  CAS  Google Scholar 

  19. Hagan JJ, Middlemiss DN, Sharpe PC, Poste GH. Parkinson's disease: prospects for improved drug therapy. Trends Pharmacol Sci 1997;18(5):156–63.

    Article  PubMed  CAS  Google Scholar 

  20. Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989;12(10):366–75.

    Article  PubMed  CAS  Google Scholar 

  21. Brotchie JM, Mitchell IJ, Sambrook MA, Crossman AR. Alleviation of parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate. Mov Disord 1991;6(2):133–8.

    Article  PubMed  CAS  Google Scholar 

  22. Carlsson M, Carlsson A. The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. J Neural Transm 1989;75(3):221–6.

    Article  PubMed  CAS  Google Scholar 

  23. Engber TM, Papa SM, Boldry RC, Chase TN. NMDA receptor blockade reverses motor response alterations induced by levodopa. Neuroreport 1994;5(18):2586–8.

    Article  PubMed  CAS  Google Scholar 

  24. Greenamyre JT, O'Brien CF. N-methyl-D-aspartate antagonists in the treatment of Parkinson's disease. Arch Neurol 1991;48(9):977–81.

    Article  PubMed  CAS  Google Scholar 

  25. Klockgether T, Turski L, Honore T, et al. The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys. Ann Neurol 1991;30(5):717–23.

    Article  PubMed  CAS  Google Scholar 

  26. Loschmann PA, Lange KW, Kunow M, et al. Synergism of the AMPA-antagonist NBQX and the NMDA-antagonist CPP with L-dopa in models of Parkinson's disease. J Neural Transm Park Dis Dement Sect 1991;3(3):203–13.

    Article  PubMed  CAS  Google Scholar 

  27. Mitchell IJ, Hughes N, Carroll CB, Brotchie JM. Reversal of parkinsonian symptoms by intrastriatal and systemic manipulations of excitatory amino acid and dopamine transmission in the bilateral 6-OHDA lesioned marmoset. Behav Pharmacol 1995; 6(5 And 6):492–507.

    PubMed  CAS  Google Scholar 

  28. Papa SM, Chase TN. Levodopa-induced dyskinesias improved by a glutamate antagonist in Parkinsonian monkeys. Ann Neurol 1996;39(5):574–8.

    Article  PubMed  CAS  Google Scholar 

  29. Klockgether T, Jacobsen P, Loschmann PA, Turski L. The antiparkinsonian agent budipine is an N-methyl-D-aspartate antagonist. J Neural Transm Park Dis Dement Sect 1993;5(2):101–6.

    Article  PubMed  CAS  Google Scholar 

  30. Meshul CK, Emre N, Nakamura CM, Allen C, Donohue MK, Buckman JF. Time-dependent changes in striatal glutamate synapses following a 6-hydroxydopamine lesion. Neuroscience 1999;88(1):1–16.

    Article  PubMed  CAS  Google Scholar 

  31. Meshul CK, Cogen JP, Cheng HW, Moore C, Krentz L, McNeill TH. Alterations in rat striatal glutamate synapses following a lesion of the cortico- and/or nigrostriatal pathway. Exp Neurol 2000;165(1):191–206.

    Article  PubMed  CAS  Google Scholar 

  32. Hepler JR, Harden TK. Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells. Biochem J 1986;239(1):141–6.

    PubMed  CAS  Google Scholar 

  33. Hepler JR, Toomim CS, McCarthy KD, et al. Characterization of antisera to glutamate and aspartate. J Histochem Cytochem 1988;36(1):13–22.

    Article  PubMed  CAS  Google Scholar 

  34. Meshul CK, Buckman JF, Allen C, Riggan JP, Feller DJ. Activation of corticostriatal pathway leads to similar morphological changes observed following haloperidol treatment. Synapse 1996;22(4):350–61.

    Article  PubMed  CAS  Google Scholar 

  35. Dube L, Smith AD, Bolam JP. Identification of synaptic terminals of thalamic or cortical origin in contact with distinct medium-size spiny neurons in the rat neostriatum. J Comp Neurol 1988;267(4):455–71.

    Article  PubMed  CAS  Google Scholar 

  36. Smith Y, Bennett BD, Bolam JP, Parent A, Sadikot AF. Synaptic relationships between dopaminergic afferents and cortical or thalamic input in the sensorimotor territory of the striatum in monkey. J Comp Neurol 1994;344(1):1–19.

    Article  PubMed  CAS  Google Scholar 

  37. Fremeau RT, Jr., Troyer MD, Pahner I, et al. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron 2001;31(2):247–60.

    Article  PubMed  CAS  Google Scholar 

  38. Kita H, Kitai ST. Efferent projections of the subthalamic nucleus in the rat: light and electron microscopic analysis with the PHA-L method. J Comp Neurol 1987;260(3): 435–52.

    Article  PubMed  CAS  Google Scholar 

  39. Touchon JC, Holmer HK, Moore C, McKee BL, Frederickson J, Meshul CK. Apomorphine-induced alterations in striatal and substantia nigra pars reticulata glutamate following unilateral loss of striatal dopamine. Exp Neurol 2005;193(1):131–40.

    Article  PubMed  CAS  Google Scholar 

  40. Ingham CA, Hood SH, Taggart P, Arbuthnott GW. Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway. J Neurosci 1998;18(12):4732–43.

    PubMed  CAS  Google Scholar 

  41. Mark KA, Quinton MS, Russek SJ, Yamamoto BK. Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release. J Neurosci 2007;27(25):6823–31.

    Article  PubMed  CAS  Google Scholar 

  42. Bacci JJ, Kachidian P, Kerkerian-Le Goff L, Salin P. Intralaminar thalamic nuclei lesions: widespread impact on dopamine denervation-mediated cellular defects in the rat basal ganglia. J Neuropathol Exp Neurol 2004;63(1):20–31.

    PubMed  Google Scholar 

  43. Cenci MA, Bjorklund A. Transection of corticostriatal afferents reduces amphetamine- and apomorphine-induced striatal Fos expression and turning behaviour in unilaterally 6-hydroxydopamine-lesioned rats. Eur J Neurosci 1993;5(8):1062–70.

    Article  PubMed  CAS  Google Scholar 

  44. Crossman AR, Sambrook MA, Gergies SW, Slater P. The neurological basis of motor asymmetry following unilateral 6-hydroxydopamine brain lesions in the rat: the effect of motor decortication. J Neurol Sci 1977;34(3):407–14.

    Article  PubMed  CAS  Google Scholar 

  45. Mura A, Feldon J, Mintz M. Reevaluation of the striatal role in the expression of turning behavior in the rat model of Parkinson's disease. Brain Res 1998;808(1):48–55.

    Article  PubMed  CAS  Google Scholar 

  46. Geinisman Y, deToledo-Morrell L, Morrell F. Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities. Brain Res 1991;566(1–2):77–88.

    Article  PubMed  CAS  Google Scholar 

  47. Greenough WT, West RW, DeVoogd TJ. Subsynaptic plate perforations: changes with age and experience in the rat. Science 1978;202(4372):1096–8.

    Article  PubMed  CAS  Google Scholar 

  48. Meshul CK, Allen C. Haloperidol reverses the changes in striatal glutamatergic immunolabeling following a 6-OHDA lesion. Synapse 2000;36(2):129–42.

    Article  PubMed  CAS  Google Scholar 

  49. Nitsch and Riesenberg (1986)

    Google Scholar 

  50. Kish SJ, Rajput A, Gilbert J, et al. Elevated gamma-aminobutyric acid level in striatal but not extrastriatal brain regions in Parkinson's disease: correlation with striatal dopamine loss. Ann Neurol 1986;20(1):26–31.

    Article  PubMed  CAS  Google Scholar 

  51. Jimenez-Jimenez FJ, Molina JA, Vargas C, et al. Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease. J Neurol Sci 1996;141(1–2):39–44.

    Article  PubMed  CAS  Google Scholar 

  52. Perry TL, Javoy-Agid F, Agid Y, Fibiger HC. Striatal GABAergic neuronal activity is not reduced in Parkinson's disease. J Neurochem 1983;40(4):1120–3.

    Article  PubMed  CAS  Google Scholar 

  53. Tanaka Y, Niijima K, Mizuno Y, Yoshida M. Changes in gamma-aminobutyrate, glutamate, aspartate, glycine, and taurine contents in the striatum after unilateral nigrostriatal lesions in rats. Exp Neurol 1986;91(2):259–68.

    Article  PubMed  CAS  Google Scholar 

  54. Jonkers N, Sarre S, Ebinger G, Michotte Y. MK801 suppresses the L-DOPA-induced increase of glutamate in striatum of hemi-Parkinson rats. Brain Res 2002;926(1–2):149–55.

    Article  PubMed  CAS  Google Scholar 

  55. Lindefors N, Ungerstedt U. Bilateral regulation of glutamate tissue and extracellular levels in caudate-putamen by midbrain dopamine neurons. Neurosci Lett 1990;115(2–3): 248–52.

    Article  PubMed  CAS  Google Scholar 

  56. Tossman U, Segovia J, Ungerstedt U. Extracellular levels of amino acids in striatum and globus pallidus of 6-hydroxydopamine-lesioned rats measured with microdialysis. Acta Physiol Scand 1986;127(4):547–51.

    Article  PubMed  CAS  Google Scholar 

  57. Abarca J, Bustos G. Differential regulation of glutamate, aspartate and gamma-amino-butyrate release by N-methyl-D-aspartate receptors in rat striatum after partial and extensive lesions to the nigro-striatal dopamine pathway. Neurochem Int 1999;35(1):19–33.

    Article  PubMed  CAS  Google Scholar 

  58. Bianchi L, Ballini C, Colivicchi MA, Della Corte L, Giovannini MG, Pepeu G. Investigation on acetylcholine, aspartate, glutamate and GABA extracellular levels from ventral hippocampus during repeated exploratory activity in the rat. Neurochem Res 2003;28(3–4):565–73.

    Article  PubMed  CAS  Google Scholar 

  59. Marti M, Mela F, Bianchi C, Beani L, Morari M. Striatal dopamine-NMDA receptor interactions in the modulation of glutamate release in the substantia nigra pars reticulata in vivo: opposite role for D1 and D2 receptors. J Neurochem 2002;83(3):635–44.

    Article  PubMed  CAS  Google Scholar 

  60. Reid MS, Herrera-Marschitz M, Hokfelt T, Lindefors N, Persson H, Ungerstedt U. Striatonigral GABA, dynorphin, substance P and neurokinin A modulation of nigrostriatal dopamine release: evidence for direct regulatory mechanisms. Exp Brain Res 1990;82(2):293–303.

    Article  PubMed  CAS  Google Scholar 

  61. Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci 2002;22(20):9134–41.

    PubMed  CAS  Google Scholar 

  62. Meshul CK, Kamel D, Moore C, Kay TS, Krentz L. Nicotine alters striatal glutamate function and decreases the apomorphine-induced contralateral rotations in 6-OHDA-lesioned rats. Exp Neurol 2002;175(1):257–74.

    Article  PubMed  CAS  Google Scholar 

  63. Wolf ME, Xue CJ, Li Y, Wavak D. Amphetamine increases glutamate efflux in the rat ventral tegmental area by a mechanism involving glutamate transporters and reactive oxygen species. J Neurochem 2000;75(4):1634–44.

    Article  PubMed  CAS  Google Scholar 

  64. Kanai Y, Hediger MA. The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects. Pflugers Arch 2004;447(5):469-79.

    Article  PubMed  CAS  Google Scholar 

  65. Katsumori H, Baldwin RA, Wasterlain CG. Reverse transport of glutamate during depolarization in immature hippocampal slices. Brain Res 1999;819(1–2):160–4.

    Article  PubMed  CAS  Google Scholar 

  66. Ohta K, Nomura T, Kanno T, et al. L-trans-PDC enhances hippocampal neuronal activity by stimulating glial glutamate release independently of blocking transporters. Biochem Biophys Res Commun 2002;295(2):376–81.

    Article  PubMed  CAS  Google Scholar 

  67. Cavelier P, Hamann M, Rossi D, Mobbs P, Attwell D. Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences. Prog Biophys Mol Biol 2005;87(1):3–16.

    Article  PubMed  CAS  Google Scholar 

  68. Smith Y, Charara A, Parent A. Synaptic innervation of midbrain dopaminergic neurons by glutamate-enriched terminals in the squirrel monkey. J Comp Neurol 1996;364(2):231–53.

    Article  PubMed  CAS  Google Scholar 

  69. Bergman H, Wichmann T, DeLong MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 1990;249(4975):1436–8.

    Article  PubMed  CAS  Google Scholar 

  70. Obeso JA, Guridi J, Obeso JA, DeLong M. Surgery for Parkinson's disease. J Neurol Neurosurg Psychiatry 1997;62(1):2–8.

    Article  PubMed  CAS  Google Scholar 

  71. McPherson RJ, Marshall JF. Substantia nigra glutamate antagonists produce contralateral turning and basal ganglia Fos expression: interactions with D1 and D2 dopamine receptor agonists. Synapse 2000;36(3):194–204.

    Article  PubMed  CAS  Google Scholar 

  72. Geffen LB, Jessell TM, Cuello AC, Iversen LL. Release of dopamine from dendrites in rat substantia nigra. Nature 1976;260(5548):258–60.

    Article  PubMed  CAS  Google Scholar 

  73. Rosales MG, Martinez-Fong D, Morales R, et al. Reciprocal interaction between glutamate and dopamine in the pars reticulata of the rat substantia nigra: a microdialysis study. Neuroscience 1997;80(3):803–10.

    Article  PubMed  CAS  Google Scholar 

  74. Pelled G, Bergman H, Goelman G. Bilateral overactivation of the sensorimotor cortex in the unilateral rodent model of Parkinson's disease – a functional magnetic resonance imaging study. Eur J Neurosci 2002;15(2):389–94.

    Article  PubMed  Google Scholar 

  75. Touchon JC, Moore C, Frederickson J, Meshul CK. Lesion of subthalamic or motor thalamic nucleus in 6-hydroxydopamine-treated rats: effects on striatal glutamate and apomorphine-induced contralateral rotations. Synapse 2004;51(4):287–98.

    Article  PubMed  CAS  Google Scholar 

  76. Marti M, Sbrenna S, Fuxe K, Bianchi C, Beani L, Morari M. Increased responsivity of glutamate release from the substantia nigra pars reticulata to striatal NMDA receptor blockade in a model of Parkinson's disease. A dual probe microdialysis study in hemiparkinsonian rats. Eur J Neurosci 2000;12(5):1848–50.

    Article  PubMed  CAS  Google Scholar 

  77. Ochi M, Shiozaki S, Kase H. Adenosine A(2A) receptor-mediated modulation of GABA and glutamate release in the output regions of the basal ganglia in a rodent model of Parkinson's disease. Neuroscience 2004;127(1):223–31.

    Article  PubMed  CAS  Google Scholar 

  78. Ochi M, Shiozaki S, Kase H. L-DOPA-induced modulation of GABA and glutamate release in substantia nigra pars reticulata in a rodent model of Parkinson's disease. Synapse 2004;52(2):163–5.

    Article  PubMed  CAS  Google Scholar 

  79. You ZB, Herrera-Marschitz M, Pettersson E, et al. Modulation of neurotransmitter release by cholecystokinin in the neostriatum and substantia nigra of the rat: regional and receptor specificity. Neuroscience 1996;74(3):793–804.

    Article  PubMed  CAS  Google Scholar 

  80. Maragakis NJ, Rothstein JD. Glutamate transporters: animal models to neurologic disease. Neurobiol Dis 2004;15(3):461–73.

    Article  PubMed  CAS  Google Scholar 

  81. Lievens JC, Salin P, Nieoullon A, Kerkerian-Le Goff L. Nigrostriatal denervation does not affect glutamate transporter mRNA expression but subsequent levodopa treatment selectively increases GLT1 mRNA and protein expression in the rat striatum. J Neurochem 2001;79(4):893–902.

    Article  PubMed  CAS  Google Scholar 

  82. Bergman H, Wichmann T, Karmon B, DeLong MR. The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. J Neurophysiol 1994;72(2):507–20.

    PubMed  CAS  Google Scholar 

  83. Crossman AR, Mitchell IJ, Sambrook MA. Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey. Neuropharmacology 1985;24(6):587–91.

    Article  PubMed  CAS  Google Scholar 

  84. Mitchell IJ, Cross AJ, Sambrook MA, Crossman AR. Neural mechanisms mediating 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced parkinsonism in the monkey: relative contributions of the striatopallidal and striatonigral pathways as suggested by 2-deoxyglucose uptake. Neurosci Lett 1986;63(1):61–5.

    Article  PubMed  CAS  Google Scholar 

  85. Vila M, Levy R, Herrero MT, et al. Metabolic activity of the basal ganglia in parkinsonian syndromes in human and non-human primates: a cytochrome oxidase histochemistry study. Neuroscience 1996;71(4):903–12.

    Article  PubMed  CAS  Google Scholar 

  86. Vila M, Levy R, Herrero MT, et al. Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and nonhuman primates: an in situ hybridization study of cytochrome oxidase subunit I mRNA. J Neurosci 1997;17(2):765–73.

    PubMed  CAS  Google Scholar 

  87. Benazzouz A, Gross C, Feger J, Boraud T, Bioulac B. Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys. Eur J Neurosci 1993;5(4):382–9.

    Article  PubMed  CAS  Google Scholar 

  88. Limousin P, Pollak P, Benazzouz A, et al. Bilateral subthalamic nucleus stimulation for severe Parkinson's disease. Mov Disord 1995;10(5):672–4.

    Article  PubMed  CAS  Google Scholar 

  89. Pollak P, Benabid AL, Limousin P, et al. Subthalamic nucleus stimulation alleviates akinesia and rigidity in parkinsonian patients. Adv Neurol 1996;69:591–4.

    PubMed  CAS  Google Scholar 

  90. Soares J, Kliem MA, Betarbet R, Greenamyre JT, Yamamoto B, Wichmann T. Role of external pallidal segment in primate parkinsonism: comparison of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism and lesions of the external pallidal segment. J Neurosci 2004;24(29):6417–26.

    Article  PubMed  CAS  Google Scholar 

  91. Hassani OK, Mouroux M, Feger J. Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus. Neuroscience 1996;72(1):105–15.

    Article  PubMed  CAS  Google Scholar 

  92. Gatev P, Darbin O, Wichmann T. Oscillations in the basal ganglia under normal conditions and in movement disorders. Mov Disord 2006;21(10):1566–77.

    Article  PubMed  Google Scholar 

  93. Galvan A, Kuwajima M, Smith Y. Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function? Neuroscience 2006;143(2):351–75.

    Article  PubMed  CAS  Google Scholar 

  94. Hammond C, Rouzaire-Dubois B, Feger J, Jackson A, Crossman AR. Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and nucleus tegmenti pedunculopontinus in the rat. Neuroscience 1983;9(1):41–52.

    Article  PubMed  CAS  Google Scholar 

  95. Clarke NP, Bevan MD, Cozzari C, Hartman BK, Bolam JP. Glutamate-enriched cholinergic synaptic terminals in the entopeduncular nucleus and subthalamic nucleus of the rat. Neuroscience 1997;81(2):371–85.

    Article  PubMed  CAS  Google Scholar 

  96. Kaneko T, Fujiyama F, Hioki H. Immunohistochemical localization of candidates for vesicular glutamate transporters in the rat brain. J Comp Neurol 2002;444(1):39–62.

    Article  PubMed  CAS  Google Scholar 

  97. Baron MS, Vitek JL, Bakay RA, et al. Treatment of advanced Parkinson's disease by unilateral posterior GPi pallidotomy: 4-year results of a pilot study. Mov Disord 2000;15(2):230–7.

    Article  PubMed  Google Scholar 

  98. Baron MS, Wichmann T, Ma D, DeLong MR. Effects of transient focal inactivation of the basal ganglia in parkinsonian primates. J Neurosci 2002;22(2):592–9.

    PubMed  CAS  Google Scholar 

  99. Chesselet MF, Delfs JM. Basal ganglia and movement disorders: an update. Trends Neurosci 1996;19(10):417–22.

    PubMed  CAS  Google Scholar 

  100. Beurrier C, Congar P, Bioulac B, Hammond C. Subthalamic nucleus neurons switch from single-spike activity to burst-firing mode. J Neurosci 1999;19(2):599–609.

    PubMed  CAS  Google Scholar 

  101. Plenz D, Kital ST. A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus. Nature 1999;400(6745):677–82.

    Article  PubMed  CAS  Google Scholar 

  102. Oh JD, Russell DS, Vaughan CL, Chase TN. Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: effect of dopaminergic denervation and L-DOPA administration. Brain Res 1998;813(1):150–9.

    Article  PubMed  CAS  Google Scholar 

  103. Nambu A, Tokuno H, Takada M. Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway. Neurosci Res 2002;43(2):111–7.

    Article  PubMed  Google Scholar 

  104. Bevan MD, Bolam JP. Cholinergic, GABAergic, and glutamate-enriched inputs from the mesopontine tegmentum to the subthalamic nucleus in the rat. J Neurosci 1995;15(11):7105–20.

    PubMed  CAS  Google Scholar 

  105. Rawls SM, McGinty JF. L-trans-pyrrolidine-2,4-dicarboxylic acid-evoked striatal glutamate levels are attenuated by calcium reduction, tetrodotoxin, and glutamate receptor blockade. J Neurochem 1997;68(4):1553–63.

    Article  PubMed  CAS  Google Scholar 

  106. Parrot S, Bert L, Renaud B, Denoroy L. Glutamate and aspartate do not exhibit the same changes in their extracellular concentrations in the rat striatum after N-methyl-D-aspartate local administration. J Neurosci Res 2003;71(3):445–54.

    Article  PubMed  CAS  Google Scholar 

  107. Smith JC, Whitton PS. The regulation of NMDA-evoked dopamine release by nitric oxide in the frontal cortex and raphe nuclei of the freely moving rat. Brain Res 2001;889(1–2):57–62.

    Article  PubMed  CAS  Google Scholar 

  108. Levy R, Lang AE, Dostrovsky JO, et al. Lidocaine and muscimol microinjections in subthalamic nucleus reverse Parkinsonian symptoms. Brain 2001;124(Pt 10):2105–18.

    Article  PubMed  CAS  Google Scholar 

  109. Marks et al. 2006

    Google Scholar 

  110. Breit S, Lessmann L, Unterbrink D, Popa RC, Gasser T, Schulz JB. Lesion of the pedunculopontine nucleus reverses hyperactivity of the subthalamic nucleus and substantia nigra pars reticulata in a 6-hydroxydopamine rat model. Eur J Neurosci 2006;24(8):2275–82.

    Article  PubMed  CAS  Google Scholar 

  111. Stefani A, Lozano AM, Peppe A, et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain 2007;130(Pt 6):1596–607.

    Article  PubMed  Google Scholar 

  112. Klockgether T, Turski L. NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats. Ann Neurol 1990;28(4):539–46.

    Article  PubMed  CAS  Google Scholar 

  113. Hernandez-Lopez S, Flores G, Rosales MG, Sierra A, Martinez-Fong D, Aceves J. Muscarinic antagonists microinjected into the subthalamic nucleus decrease muscular rigidity in reserpinized rats. Neurosci Lett 1996;213(3):157–60.

    PubMed  CAS  Google Scholar 

  114. Phillips JM, Lam HA, Ackerson LC, Maidment NT. Blockade of mGluR glutamate receptors in the subthalamic nucleus ameliorates motor asymmetry in an animal model of Parkinson's disease. Eur J Neurosci 2006;23(1):151–60.

    Article  PubMed  Google Scholar 

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Acknowledgments

This research was supported by the Department of Veterans Affairs Merit Review Program. This work was carried out by a number of outstanding lab assistants over the past many years, including Cindy Moore, Justin Touchon, Carrie Nakamura, Jeffery Wiedemann, Modjgan Keyghobadi, Haley Holmer , Adrienne Tozier de la Poterie and graduate students, including Brenda McKee and Kristin McCarthy.

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  1. Research Service, Neurocytology Lab, VA Medical Center and Department of Behavioral Neuroscience and Pathology Oregon Health & Science University, Portland, OR, USA

    Charles K. Meshul

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Correspondence to Charles K. Meshul .

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    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

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    Meshul, C.K. (2009). Glutamate Plasticity in an Animal Model of Parkinson’s Disease. In: Tseng, KY. (eds) Cortico-Subcortical Dynamics in Parkinson's Disease. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60327-252-0_13

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