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Intracerebral Hemorrhage: Long-Term Complications and Prevention

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Stroke Essentials for Primary Care

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References

  1. Sacco RL, Mayer SA. Epidemiology of Intracerebral Hemorrhage. In: Feldmann E, ed. Intracerebral hemorrhage. Armonk, NY: Futura, 1994: 3–26.

    Google Scholar 

  2. Foulkes MA, Wolf PA, Price TR, Mohr JP, Hier DB. The Stroke Data Bank: design, methods, and baseline characteristics. Stroke 1988; 19(5):547–554.

    Article  PubMed  CAS  Google Scholar 

  3. Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P. Antithrombotic and Thrombolytic Therapy for Ischemic Stroke: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126(3_suppl):483S–512.

    Article  PubMed  CAS  Google Scholar 

  4. Douglas MA, Haerer AF. Long-term prognosis of hypertensive intracerebral hemorrhage. Stroke 1982; 13(4):488–491.

    Article  PubMed  CAS  Google Scholar 

  5. Helweg-Larsen S, Sommer W, Strange P, Lester J, Boysen G. Prognosis for patients treated conservatively for spontaneous intracerebral hematomas. Stroke 1984; 15(6):1045–1048.

    Article  PubMed  CAS  Google Scholar 

  6. Counsell C, Boonyakarnkul S, Dennis M, Sandercock P, Bamford J, Burn J, et al. Primary intracerebral haemorrhage in the Oxfordshire Community Stroke Project. 2. Prognosis. Cerebrovascular Diseases 1995; 5:26–34.

    Article  Google Scholar 

  7. Broderick JP, Brott TG, Duldner JE, Tomsick T, Huster G. Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality. Stroke 1993; 24(7):987–993.

    Article  PubMed  CAS  Google Scholar 

  8. Lisk DR, Pasteur W, Rhoades H, Putnam RD, Grotta JC. Early presentation of hemispheric intracerebral hemorrhage: prediction of outcome and guidelines for treatment allocation. Neurology 1994; 44(1):133–139.

    PubMed  CAS  Google Scholar 

  9. Dennis MS, Burn JP, Sandercock PA, Bamford JM, Wade DT, Warlow CP. Long-term survival after first-ever stroke: the Oxfordshire Community Stroke Project. Stroke 1993; 24(6):796–800.

    Article  PubMed  CAS  Google Scholar 

  10. Tuhrim S, Horowitz DR, Sacher M, Godbold JH. Validation and comparison of models predicting survival following intracerebral hemorrhage. Critical Care Medicine 1995; 23(5):950–954.

    Article  PubMed  CAS  Google Scholar 

  11. Tuhrim S, Horowitz DR, Sacher M, Godbold JH. Validation and comparison of models predicting survival following intracerebral hemorrhage. Critical Care Medicine 1995; 23(5):950–954.

    Article  PubMed  CAS  Google Scholar 

  12. Atrial Fibrillations Investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials. Archives of Internal Medicine 1994; 154(13):1449–1457.

    Article  Google Scholar 

  13. Hart RG, Boop BS, Anderson DC. Oral anticoagulants and intracranial hemorrhage. Facts and hypotheses. Stroke 1995; 26(8):1471–1477.

    Article  PubMed  CAS  Google Scholar 

  14. Radberg JA, Olsson JE, Radberg CT. Prognostic parameters in spontaneous intracerebral hematomas with special reference to anticoagulant treatment. Stroke 1991; 22(5):571–576.

    Article  PubMed  CAS  Google Scholar 

  15. Flibotte JJ, Hagan N, O'Donnell J, Greenberg SM, Rosand J. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology 2004; 63(6):1059–1064.

    PubMed  CAS  Google Scholar 

  16. Rosand J, Eckman MH, Knudsen KA, Singer DE, Greenberg SM. The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Archives of Internal Medicine 2004; 164(8):880–884.

    Article  PubMed  CAS  Google Scholar 

  17. Hemphill JC, 3rd, Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke 2001; 32(4):891–897.

    Article  PubMed  Google Scholar 

  18. Gebel JM, Jr, Jauch EC, Brott TG, Khoury J, Sauerbeck L, Salisbury S, et al. Relative Edema Volume Is a Predictor of Outcome in Patients With Hyperacute Spontaneous Intracerebral Hemorrhage. Stroke 2002; 33(11):2636–2641.

    Article  PubMed  Google Scholar 

  19. Davis SM, Broderick J, Hennerici M, Brun NC, Diringer MN, Mayer SA, et al. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology 2006; 66(8):1175–1181.

    Article  PubMed  CAS  Google Scholar 

  20. Diringer MN, Edwards DF, Zazulia AR. Hydrocephalus: a previously unrecognized predictor of poor outcome from supratentorial intracerebral hemorrhage. Stroke 1998; 29(7):1352–1357.

    Article  PubMed  CAS  Google Scholar 

  21. Becker KJ, Baxter AB, Bybee HM, Tirschwell DL, Abouelsaad T, Cohen WA. Extravasation of radiographic contrast is an independent predictor of death in primary intracerebral hemorrhage. Stroke 1999; 30(10):2025–2032.

    Article  PubMed  CAS  Google Scholar 

  22. Fogelholm R, Avikainen S, Murros K. Prognostic value and determinants of first-day mean arterial pressure in spontaneous supratentorial intracerebral hemorrhage. Stroke 1997; 28(7):1396–1400.

    Article  PubMed  CAS  Google Scholar 

  23. Passero S, Ciacci G, Ulivelli M. The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage. Neurology 2003; 61(10):1351–1356.

    PubMed  Google Scholar 

  24. Dandapani BK, Suzuki S, Kelley RE, Reyes-Iglesias Y, Duncan RC. Relation between blood pressure and outcome in intracerebral hemorrhage. Stroke 1995; 26(1):21–24.

    Article  PubMed  CAS  Google Scholar 

  25. Tuhrim S, Dambrosia JM, Price TR, Mohr JP, Wolf PA, Heyman A, et al. Prediction of intracerebral hemorrhage survival. Annals of Neurology 1988; 24(2):258–263.

    Article  PubMed  CAS  Google Scholar 

  26. Greenberg SM, Eng JA, Ning M, Smith EE, Rosand J. Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke 2004; 35(6):1415–1420.

    Article  PubMed  Google Scholar 

  27. Castellanos M, Leira R, Tejada J, Gil-Peralta A, Davalos A, Castillo J. Predictors of good outcome in medium to large spontaneous supratentorial intracerebral haemorrhages. Journal of Neurology Neurosurgery and Psychiatry 2005; 76(5):691–695.

    Article  CAS  Google Scholar 

  28. Ariesen MJ, Algra A, van der Worp HB, Rinkel GJ. Applicability and relevance of models that predict short term outcome after intracerebral haemorrhage. Journal of Neurology Neurosurgery and Psychiatry 2005; 76(6):839–844.

    Article  CAS  Google Scholar 

  29. Zurasky JA, Aiyagari V, Zazulia AR, Shackelford A, Diringer MN. Early mortality following spontaneous intracerebral hemorrhage. Neurology 2005; 64(4):725–727.

    Article  PubMed  CAS  Google Scholar 

  30. Becker KJ, Baxter AB, Cohen WA, Bybee HM, Tirschwell DL, Newell DW, et al. Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling prophecies. Neurology 2001; 56(6):766–772.

    PubMed  CAS  Google Scholar 

  31. Hemphill JC, 3rd, Newman J, Zhao S, Johnston SC. Hospital usage of early do-not-resuscitate orders and outcome after intracerebral hemorrhage. Stroke 2004; 35(5):1130–1134.

    Article  PubMed  Google Scholar 

  32. Qureshi AI, Safdar K, Weil J, Barch C, Bliwise DL, Colohan AR, et al. Predictors of early deterioration and mortality in black Americans with spontaneous intracerebral hemorrhage. Stroke 1995; 26(10):1764–1767.

    Article  PubMed  CAS  Google Scholar 

  33. Mayer S, Sacco R, Shi T, Mohr J. Neurologic deterioration in noncomatose patients with supratentorial intracerebral hemorrhage. Neurology 1994; 44:1379–1384.

    PubMed  CAS  Google Scholar 

  34. Zazulia AR, Diringer MN, Derdeyn CP, Powers WJ. Progression of mass effect after intracerebral hemorrhage. Stroke 1999; 30(6):1167–1173.

    Article  PubMed  CAS  Google Scholar 

  35. Kazui S, Naritomi H, Yamamoto H, Sawada T, Yamaguchi T. Enlargement of spontaneous intracerebral hemorrhage. Incidence and time course. Stroke 1996; 27(10):1783–1787.

    Article  PubMed  CAS  Google Scholar 

  36. Fujii Y, Tanaka R, Takeuchi S, Koike T, Minakawa T, Sasaki O. Hematoma enlargement in spontaneous intracerebral hemorrhage [see comments]. Journal of Neurosurgery 1994; 80(1):51–57.

    Article  PubMed  CAS  Google Scholar 

  37. Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke 1997; 28:1–5.

    Article  PubMed  CAS  Google Scholar 

  38. Faught E, Peters D, Bartolucci A, Moore L, Miller PC. Seizures after primary intracerebral hemorrhage. Neurology 1989; 39(8):1089–1093.

    PubMed  CAS  Google Scholar 

  39. Berger AR, Lipton RB, Lesser ML, Lantos G, Portenoy RK. Early seizures following intracerebral hemorrhage: implications for therapy. Neurology 1988; 38(9):1363–1365.

    PubMed  CAS  Google Scholar 

  40. Vespa PM, O'Phelan K, Shah M, Mirabelli J, Starkman S, Kidwell C, et al. Acute seizures after intracerebral hemorrhage: A factor in progressive midline shift and outcome. Neurology 2003; 60(9):1441–1446.

    PubMed  CAS  Google Scholar 

  41. Broderick JP, Adams HP, Barsan W, Feinberg W, Feldmann E, Grotta J, et al. Guidelines for the management of spontaneous intracerebral hemorrhage. Stroke 1999; 30:905–915.

    Article  PubMed  CAS  Google Scholar 

  42. Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. The New England Journal of Medicine 2001; 344(19):1450–1460.

    Article  PubMed  CAS  Google Scholar 

  43. Cervoni L, Artico M, Salvati M, Bristot R, Franco C, Delfini R. Epileptic seizures in intracerebral hemorrhage: a clinical and prognostic study of 55 cases. Neurosurgical Review 1994; 17(3):185–188.

    Article  PubMed  CAS  Google Scholar 

  44. Yablon SA, Rock WA, Jr., Nick TG, Sherer M, McGrath CM, Goodson KH. Deep vein thrombosis: prevalence and risk factors in rehabilitation admissions with brain injury. Neurology 2004; 63(3):485–491.

    PubMed  CAS  Google Scholar 

  45. Boeer A, Voth E, Henze T, Prange HW. Early heparin therapy in patients with spontaneous intracerebral haemorrhage. Journal of Neurology Neurosurgery and Psychiatry 1991; 54(5):466–467.

    Article  CAS  Google Scholar 

  46. Hill MD, Silver FL, Austin PC, Tu JV. Rate of stroke recurrence in patients with primary intracerebral hemorrhage. Stroke 2000; 31(1):123–127.

    Article  PubMed  CAS  Google Scholar 

  47. Bailey RD, Hart RG, Benavente O, Pearce LA. Recurrent brain hemorrhage is more frequent than ischemic stroke after intracranial hemorrhage. Neurology 2001; 56(6):773–777.

    PubMed  CAS  Google Scholar 

  48. Gonzalez-Duarte A, Cantu C, Ruiz-Sandoval JL, Barinagarrementeria F. Recurrent primary cerebral hemorrhage: frequency, mechanisms, and prognosis. Stroke 1998; 29(9):1802–1805.

    Article  PubMed  CAS  Google Scholar 

  49. Smith EE, Gurol ME, Eng JA, Engel CR, Nguyen TN, Rosand J, et al. White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage. Neurology 2004; 63(9):1606–1612.

    PubMed  CAS  Google Scholar 

  50. O'Donnell HC, Rosand J, Knudsen KA, Furie KL, Segal AZ, Chiu RI, et al. Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage [see comments]. The New England Journal of Medicine 2000; 342(4):240–245.

    Article  PubMed  Google Scholar 

  51. Hylek EM, Singer DE. Risk factors for intracranial hemorrhage in outpatients taking warfarin. Annals of Internal Medicine 1994; 120(11):897–902.

    PubMed  CAS  Google Scholar 

  52. He J, Whelton PK, Vu B, Klag MJ. Aspirin and risk of hemorrhagic stroke: a meta-analysis of randomized controlled trials. JAMA 1998; 280(22):1930–1935.

    Article  PubMed  CAS  Google Scholar 

  53. Wong KS, Mok V, Lam WW, Kay R, Tang A, Chan YL, et al. Aspirin-associated intracerebral hemorrhage: clinical and radiologic features. Neurology 2000; 54(12):2298–2301.

    PubMed  CAS  Google Scholar 

  54. Wong KS, Chan YL, Liu JY, Gao S, Lam WWM. Asymptomatic microbleeds as a risk factor for aspirin-associated intracerebral hemorrhages. Neurology 2003; 60(3):511–513.

    PubMed  CAS  Google Scholar 

  55. Viswanathan A, Rakich SM, Engel C, Snider R, Rosand J, Greenberg SM, et al. Antiplatelet use after intracerebral hemorrhage. Neurology 2006; 66(2):206–209.

    Article  PubMed  CAS  Google Scholar 

  56. Eckman MH, Rosand J, Knudsen KA, Singer DE, Greenberg SM. Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis. Stroke 2003; 34(7):1710–1716.

    Article  PubMed  Google Scholar 

  57. Keir SL, Wardlaw JM, Sandercock PA, Chen Z. Antithrombotic therapy in patients with any form of intracranial haemorrhage: a systematic review of the available controlled studies. Cerebrovascular Diseases 2002; 14(3–4):197–206.

    Article  PubMed  CAS  Google Scholar 

  58. Phan TG, Koh M, Wijdicks EF. Safety of discontinuation of anticoagulation in patients with intracranial hemorrhage at high thromboembolic risk. [see comments.]. Archives of Neurology 2000; 57(12):1710–1713.

    Article  PubMed  CAS  Google Scholar 

  59. Saxena R, Lewis S, Berge E, Sandercock PA, Koudstaal PJ. Risk of early death and recurrent stroke and effect of heparin in 3169 patients with acute ischemic stroke and atrial fibrillation in the International Stroke Trial. Stroke 2001; 32(10):2333–2337.

    Article  PubMed  CAS  Google Scholar 

  60. Berge E, Abdelnoor M, Nakstad PH, Sandset PM. Low molecular-weight heparin versus aspirin in patients with acute ischaemic stroke and atrial fibrillation: a double-blind randomised study. HAEST Study Group. Heparin in Acute Embolic Stroke Trial. Lancet 2000; 355(9211):1205–1210.

    Article  PubMed  CAS  Google Scholar 

  61. Phillips SJ. Pathogenesis, diagnosis, and treatment of hypertension-associated stroke. American Journal of Hypertension 1989; 2(6 Pt 1):493–501.

    PubMed  CAS  Google Scholar 

  62. Woo D, Haverbusch M, Sekar P, Kissela B, Khoury J, Schneider A, et al. Effect of Untreated Hypertension on Hemorrhagic Stroke. Stroke 2004; 35(7):1703–1708.

    Article  PubMed  Google Scholar 

  63. Furlan AJ, Whisnant JP, Elveback LR. The decreasing incidence of primary intracerebral hemorrhage: a population study. Annals of Neurology 1979;5(4):367–373.

    Article  PubMed  CAS  Google Scholar 

  64. Hypertension Detection and Follow-up Program Cooperative Group T. Five-year findings of the hypertension detection and follow-up program. III. Reduction in stroke incidence among persons with high blood pressure. Hypertension Detection and Follow-up Program Cooperative Group. JAMA 1982; 247(5):633–638.

    Article  Google Scholar 

  65. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA 1991; 265(24):3255–3264.

    Article  Google Scholar 

  66. Thrift AG, Donnan GA, McNeil JJ. Heavy drinking, but not moderate or intermediate drinking, increases the risk of intracerebral hemorrhage. Epidemiology 1999; 10(3):307–312.

    Article  PubMed  CAS  Google Scholar 

  67. Gorelick PB. Alcohol and stroke. Stroke 1987; 18(1):268–271.

    Article  PubMed  CAS  Google Scholar 

  68. Klatsky AL, Armstrong MA, Friedman GD, Sidney S. Alcohol Drinking and Risk of Hemorrhagic Stroke. Neuroepidemiology 2002; 21:115–122.

    Article  PubMed  Google Scholar 

  69. Klatsky AL, Armstrong MA, Friedman GD. Alcohol use and subsequent cerebrovascular disease hospitalizations. Stroke 1989; 20(6):741–746.

    Article  PubMed  CAS  Google Scholar 

  70. Juvela S, Hillbom M, Palomaki H. Risk factors for spontaneous intracerebral hemorrhage. Stroke 1995; 26(9):1558–1564.

    Article  PubMed  CAS  Google Scholar 

  71. Greenberg S, Schneider A, Pettigrew L. Phase II study of Cerebril, a candidate treatment for intracerebral hemorrhage related to cerebral amyloid angiopathy. Neurology 2004; 62(7 Suppl 5): A102.

    Google Scholar 

  72. Stroke Prevention in Reversible Ischemia Trial (SPIRIT) Study Group T. A randomized trial of anticoagulants versus aspirin after cerebral ischemia of presumed arterial origin. The Stroke Prevention in Reversible Ischemia Trial (SPIRIT) Study Group. Annals of Neurology 1997; 42(6):857–865.

    Article  Google Scholar 

  73. Landefeld CS, Goldman L. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy. American Journal of Medicine 1989; 87(2):144–152.

    Article  PubMed  CAS  Google Scholar 

  74. Rosand J, Hylek EM, O'Donnell HC, Greenberg SM. Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study. Neurology 2000; 55(7):947–951.

    PubMed  CAS  Google Scholar 

  75. Group PC. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. Lancet 2001; 358:1033.

    Article  Google Scholar 

  76. Bae H, Jeong D, Doh J, Lee K, Yun I, Byun B. Recurrence of bleeding in patients with hypertensive intracerebral hemorrhage. Cerebrovascular Diseases 1999; 9(2):102–108.

    Article  PubMed  CAS  Google Scholar 

  77. Arakawa S, Saku Y, Ibayashi S, Nagao T, Fujishima M. Blood pressure control and recurrence of hypertensive brain hemorrhage. Stroke 1998; 29(9):1806–1809.

    Article  PubMed  CAS  Google Scholar 

  78. Passero S, Burgalassi L, D'Andrea P, Battistini N. Recurrence of bleeding in patients with primary intracerebral hemorrhage. Stroke 1995; 26(7):1189–1192.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Assistant Professor of Clinical Neurology, Division of Neurocritical Care and Stroke, Department of Neurology, University of Southern California, Los Angeles, California, USA

    Amytis Towfighi

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  1. Amytis Towfighi
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  2. David S. Liebeskind
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Editors and Affiliations

  1. The Neurology and Headache Treatment Center, Alexandria, VA, USA

    David Alway

  2. Baltimore VA Medical Center, University of Maryland, Baltimore, MD, USA

    John Walden Cole

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Towfighi, A., Liebeskind, D.S. (2009). Intracerebral Hemorrhage: Long-Term Complications and Prevention. In: Alway, D., Cole, J.W. (eds) Stroke Essentials for Primary Care. Current Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-59745-433-9_5

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