Skip to main content
SpringerLink
Log in

Sjögren’s Syndrome and Its Implications for Diet and Nutrition

  • Chapter
Nutrition and Rheumatic Disease

Part of the book series: Nutrition and Health ((NH))

Summary

• Sjögren’s syndrome is a chronic autoimmune disorder, most common in adult women.

• There is no known etiology or cure for Sjögren’s syndrome.

• Sjögren’s syndrome is characterized by debilitating ocular and oral manifestations.

• Early diagnosis and palliation are critical.

• Nutrition implications are similar to those for patients undergoing oral cancer and head and neck radiation.

• Omega-3 fatty acids have been implicated as a potential therapeutic agent.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Petruzzi LM, Vivino FB. Sjogren’s syndrome– implication for perioperative practice. The Association of Perioperative Registered Nurse 2003;77(3):611–628.

    Google Scholar 

  2. Venables PJ. Sjogrens syndrome. Best Pract Res Clin Rheumatol 2004;18(3):313–329.

    PubMed  CAS  Google Scholar 

  3. University of Washington. About Sjogren’s syndrome. http:/www.orthop.washington.edu/uw/tabID_3376, accessed 12/19/06.

    Google Scholar 

  4. Delaleu N, Jonsson R, Koller MM. Sjogren’s syndrome. Eur J Oral Sci 2005;113(2):101–113.

    Article  PubMed  CAS  Google Scholar 

  5. Chamber MS. Sjogren’s syndrome. ORL Head Neck Nurs 2004; 22(4):22–30.

    Google Scholar 

  6. Mignogna SF, et al. Sjogren’s syndrome: the diagnostic potential of early oral manifestations preceding hyposalivation/xerostomia. J Oral Pathol Med 2005;34:1–6.

    Article  PubMed  CAS  Google Scholar 

  7. Gentric A. Sicca syndromes in the elderly. Rev Prat 2001;51(2):177–180.

    PubMed  CAS  Google Scholar 

  8. Fox RI. Sjogren’s syndrome: controversies and progress. Clin Lab Med 1997;1(3):431–444.

    Google Scholar 

  9. National Institute of Neurological Illnesses and Stroke. NINDS Sjogren’s Syndrome Information Page. http://www.ninds.nih.gov/disorders/sjogrens/sjogrens.htm, accessed June14, 2006.

    Google Scholar 

  10. British Sjogren’s Syndrome Association. What is Sjogren’s syndrome? a clinical overview. http://www.rheumatology.org.uk/link/patient_support_links/britishsjogrenssyndromeassoc, Accessed July 12, 2006 7/12.

    Google Scholar 

  11. Kassan SM. Moutsopoulos H. Clinical manifestations and early diagnosis of Sjogren syndrome. JAMA 2004;164:1275–1284.

    Google Scholar 

  12. Sawyer S. Primary Sjogren’s syndrome. Nurs Stand 2004;18(23):33–36.

    PubMed  Google Scholar 

  13. Dafni UG, Tzioufas AG, Staikos P et al. Prevalence of Sjogrens syndrome in a closed rural community. Ann Rheum Dis 1997;56:521–525.

    Article  PubMed  CAS  Google Scholar 

  14. Kitagawa S, et al. Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Kuttner’s tumor). Am J Surg Pathol 2005;29(6):783–791.

    Article  PubMed  Google Scholar 

  15. Hansen A, Lipsky PE, Dorner T. Immunopathogenesis of primary Sjogren’s syndrome: implications for disease management and therapy. Curr Opin Rheumatol 2005;17(5):558–565.

    Article  PubMed  CAS  Google Scholar 

  16. Robinson C, Yamachika S. A Novel NOD derived murine model of primary Sjogren’s syndrome. Arthritis Rheum 1998;41:150–156.

    Article  PubMed  CAS  Google Scholar 

  17. Gottenberg JE, et al. Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases. Ann Rheum Dis 2005;64(6):913–920.

    Article  PubMed  CAS  Google Scholar 

  18. Haga HJ, et al. Reproduction and gynaecological manifestations in women with primary Sjogren’s syndrome: a case–control study. Scand J Rheumatol 2005;34(1):45–48.

    Article  PubMed  CAS  Google Scholar 

  19. Moutsopoulos H. Sjogren’s syndrome: autoimmune epithelitis. Clin Immunol Immunopathol 1994;74:162–165.

    Article  Google Scholar 

  20. Oxholm P, Asmussen K, Wiik A, Horrobin DF. Essential fatty acid status in cell membranes and plasma of patients with primary Sjogren’s syndrome. Correlations to clinical and immunologic variables using a new model for classification and assessment of disease manifestations. Prostaglandins Leukot Essent Fatty Acids 1998:59(4):239–245.

    Google Scholar 

  21. Abu-Helu R, Dimitriou ID. Induction of salivary gland epithelial cell injury in Sjogren’s syndrome: in vitro assessment of T cell derived cytokines and Fas protein expression. J Autoimmune 2001;17: 141–153.

    Article  CAS  Google Scholar 

  22. Muscal E, Morales de Guzman M, Jung LK, Flaitz C. Sjogren’s syndrome. 2004 (cited 2006 8/06/06). http://www.emedicine.com/ped/topic2811.htm

    Google Scholar 

  23. Dodds MWJ, Johnson DA, Yeh C-K. Health benefits of saliva: a review. J Dent 2005; 33(3):223–233.

    Google Scholar 

  24. Al-Hashimi I. Xerostomia secondary to Sjogren’s syndrome in the elderly: recognition and management. Drugs Aging 2005;22(11):887–899.

    Article  PubMed  Google Scholar 

  25. Lwin CEA. The assessment of fatigue in primary Sjogren’s syndrome. Scand J Rheumatol 2003;32(1):33–37.

    Article  PubMed  Google Scholar 

  26. Morozova RP, et al. The normal tear fluid and decreased tearing in patients with Sjogren’s disease and Sjogren’s syndrome. II. The lipid content. Ukr Biokhim Zh 1996;68(2):82–87.

    PubMed  CAS  Google Scholar 

  27. Soto-Rojas A, Villa AR, Sifuentes-Osornio J, Alarcon-Segovia D, Kraus A. Oral manifestations in patients with Sjogren’s syndrome. J Rheumatol 1998;25(5):906–910.

    PubMed  CAS  Google Scholar 

  28. Atkinson J. Sjogren’s syndrome: oral and dental considerations. J Am Dent Assoc 1993;124:74–86.

    PubMed  CAS  Google Scholar 

  29. Cermak JM, et al. Nutrient intake in women with primary and secondary Sjogren’s syndrome. Eur J Clin Nutr 2003;57(2):328–334.

    Article  PubMed  CAS  Google Scholar 

  30. Porter S, Scully C, Hegarty AM. An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 97(1):28–46.

    Google Scholar 

  31. Hay KD, Morton RP, Wall CR. Quality of life and nutritional studies in Sjogren’s syndrome patients with xerostomia. N Z Dent J 2001;97(430):128–131.

    PubMed  CAS  Google Scholar 

  32. Yoneyama K, et al. Primary localized cutaneous nodular amyloidosis in a patient with Sjogren’s syndrome: a review of the literature. J Dermatol 2005:32(2):120–123.

    Google Scholar 

  33. Schumann C, et al. Autoimmune polyglandular syndrome associated with idiopathic giant cell myocarditis. Exp Clin Endocrinol Diabetes 2005;113(5):302–307.

    Article  PubMed  CAS  Google Scholar 

  34. Terai C, Sakurai T. Renal lesions related to Sjogren’s syndrome. Nippon Naika Gakkai Zasshi 2005;94(5):871–875.

    PubMed  Google Scholar 

  35. Kassan SS, Thomas TL, Moutsopoulos HM, et al. Increased risk of lymphoma in sicca syndrome. Ann Intern Med. 1978;89(6):888–892.

    PubMed  CAS  Google Scholar 

  36. Michowitz Y, et al. Transient lower limbs paralysis—a rare presenting symptom of Sjogren’s syndrome. Harefuah 2005;144(4):241–242.

    PubMed  Google Scholar 

  37. Seve P, et al. Cricoarytenoid arthritis in Sjogren’s syndrome. Rheumatol Int 2005;25(4):301–302.

    Article  PubMed  Google Scholar 

  38. Longman L, Highan SM, Bucknall R, Kaye SB, Edgar WM, Field EA. Signs and symptoms in patients with salivary gland hypofunction. Postgrad Med J 1997;73(856):93–97.

    PubMed  CAS  Google Scholar 

  39. Dawes C. How much saliva is enough for avoidane of xerostomia? Caries Res 2004;38(3):236–240.

    Article  PubMed  CAS  Google Scholar 

  40. Hocevar A, et al. Ultrasonographic changes of major salivary glands in primary Sjogren’s syndrome. Diagnostic value of a novel scoring system. Rheumatology 2005;44(6):768–772.

    Article  PubMed  CAS  Google Scholar 

  41. Turk T, et al. Manometric assessment of esophageal motility in patients with primary Sjogren’s syndrome. Rheumatol Int 2005;25(4):246–249.

    Article  PubMed  Google Scholar 

  42. Scagliusi P, et al. New therapeutic perspectives in Sjogren syndrome: leflunomide. Recenti Prog Med 2005;96(4):194.

    Google Scholar 

  43. Derk CT, Vivino FB. A primary care approach to Sjogren’s syndrome. Helping patients cope with sicca symptoms, extraglandular manifestations. Postgrad Med 2004;116(3):49–54.

    PubMed  Google Scholar 

  44. Papas A, Sherrer YS, Charney M, et al. Successful treatment of dry mouth and dry eye symptoms in Sjogren’s syndrome patients with oral pilocarpine. A randomized placebo-controlled, dose-adjustment study. J Clin Rheumatol 2004;10:169–177.

    Article  PubMed  Google Scholar 

  45. Fox P. Management of dry mouth. Dent Clin North Am 1997;41(4):863–875.

    PubMed  CAS  Google Scholar 

  46. Papas A. The Clinicians Guide to the Diagnosis and Treatment of Salivary Gland Disorders and Chemosensory Disorders. Tufts University School of Dental Medicine, Boston, MA.

    Google Scholar 

  47. Martuscelli G, Singh M, Papas AS, Cohen J. Use of a power toothbrush in a high risk population. J Dent Res 2004;83(special issue A):2435.

    Google Scholar 

  48. Brown NA, et al. Nutrition supplements and the eye. Eye 1998;12(Pt 1):127–133.

    Google Scholar 

  49. Dry eyes? Eat more fish. Health News 2006;12(4):11.

    Google Scholar 

  50. Edgar W. Sugar substitutes, chewing gum and dental caries: a review. Br Dent J 1998;184:29–32.

    Article  PubMed  CAS  Google Scholar 

  51. Muthukumar AR, et al. Calorie restriction decreases proinflammatory cytokines and polymeric Ig receptor expression in the submandibular glands of autoimmune prone (NZB x NZW)F1 mice. J Clin Immunol 2000;20(5):354–361.

    Article  PubMed  CAS  Google Scholar 

  52. Belch JJ. Hill A. Evening primrose oil and borage oil in rheumatologic conditions. Am J Clin Nutr 2000;71(1 suppl):352S–356S.

    Google Scholar 

  53. Aragona P, et al. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren’s syndrome patients. Invest Ophthalmol Vis Sci 2005;46(12):4474–4479.

    Article  PubMed  Google Scholar 

  54. Miljanovic B, Trivedi KA, Dana MR, Gilbard JP, Buring JE, Schaumberg DA. Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women. Am J Clin Nutr 2005;82(4):887–893.

    PubMed  CAS  Google Scholar 

  55. Singh M, Singh ML, Papas AS. The Effect of an Omega-3 supplement on Dry Mouth and Dry Eyes in Sjogren’s Patients. IXth International Symposium on Sjögren’s Syndrome. Washington DC. Abstract #: 87: April 2006.

    Google Scholar 

  56. Sullivan BD, et al. Correlations between nutrient intake and the polar lipid profiles of meibomian gland secretions in women with Sjogren’s syndrome. Adv Exp Med Biol 2002;506(Pt A):441–447.

    Google Scholar 

  57. Theander E, et al. Gammalinolenic acid treatment of fatigue associated with primary Sjogren’s syndrome. Scand J Rheumatol 2002;31(2):72–79.

    Article  PubMed  Google Scholar 

  58. Aizaki T, et al. Hypokalemia with syncope caused by habitual drinking of oolong tea. Intern Med 1999;38(3):252–256.

    Article  PubMed  CAS  Google Scholar 

  59. Hsu S. Dickinson D. A new approach to managing oral manifestations of Sjogren’s syndrome and skin manifestations of lupus. J Biochem Mol Biol 2006;39(3):229–239.

    Google Scholar 

  60. Hsu S., et al. Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells. J Pharmacol Exp Ther 2005;315(2):805–811.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Carole A. Palmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Medha Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Marshfield Clinic Research Foundation, Marshfield, WI

    Laura A. Coleman PhD, RD

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Humana Press, Totowa, NJ

About this chapter

Cite this chapter

Palmer, C.A., Singh, M. (2008). Sjögren’s Syndrome and Its Implications for Diet and Nutrition. In: Coleman, L.A. (eds) Nutrition and Rheumatic Disease. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-59745-403-2_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-403-2_14

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-976-5

  • Online ISBN: 978-1-59745-403-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation