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Dietary n-3 Polyunsaturated Fatty Acids Modulate T-Lymphocyte Activation

Clinical Relevance in Treating Diseases of Chronic Inflammation

  • Chapter
Nutrition and Immunology

Abstract

Approximately 40 million Americans (1 in 7) are afflicted with arthritis. Arthritis costs the economy an estimated 54.6 billion annually in medical care and indirect costs (i.e., lost wages) and is the number one cause of disability in the United States. The Centers for Disease Control and Prevention project that by the year 2020, the number of cases of arthritis will increase to 59.4 million Americans (1). Current therapy includes the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and slow-acting antirheumatic drugs, but because of side effects, these drugs are usually not administered for more than 2 yr (2,3) The development of safer therapeutic strategies are required to improve patient quality of life in the long term. One such therapeutic approach has been the use of fish oil supplementation. Epidemiological data collected in the 1970s indicate that Greenland Eskimos have a decreased incidence of inflammatory disease despite their high-fat diet. Similar observations were made in the Japanese population, which led to the correlation between a lower incidence of inflammatory disease and high consumption, relative to Americans, of cold-water marine fish (4). Scientists have tested the effects of dietary fish oil supplementation on rheumatoid arthritis (RA) in human clinical trials (3,5).

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  1. Robert S. Chapkin
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  2. David N. McMurray
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  3. Christopher A. Jolly
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Editors and Affiliations

  1. Division of Rheumatology/Allergy and Clinical Immunology, Department of Internal Medicine, University of California at Davis, Davis, CA, USA

    M. Eric Gershwin MD

  2. Department of Food Science and Technology, University of California at Davis, Davis, CA, USA

    J. Bruce German PhD

  3. Department of Nutrition, University of California at Davis, Davis, CA, USA

    Carl L. Keen PhD

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Chapkin, R.S., McMurray, D.N., Jolly, C.A. (2000). Dietary n-3 Polyunsaturated Fatty Acids Modulate T-Lymphocyte Activation. In: Gershwin, M.E., German, J.B., Keen, C.L. (eds) Nutrition and Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-709-3_10

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  • DOI: https://doi.org/10.1007/978-1-59259-709-3_10

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