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Celiac Disease: Background and Historical Context

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Celiac Disease

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1326))

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Abstract

Medical descriptions of celiac disease date to the first century BC, and the first modern description was published in 1888. Further insights were gained throughout the 1900s, culminating in the identification of the dietary component, the major genetic determinant, and the autoantigen by the turn of the century. Understanding of the age of onset, population prevalence, and the extent of subclinical celiac disease developed in tandem. Thanks to advances in genomics, currently established loci account for over 50 % of the genetic risk. Nonetheless, much remains to be discovered. Advances in high-throughput genomic, biochemical, and cell analyses, as well as the bioinformatics needed to process the data, promise to deepen our understanding further. Here we present a primer of celiac disease, viewing the condition in turn from the historical, epidemiological, immunological, molecular, and genetic points of view. Research into any ailment has specific requirements: study subjects must be identified and relevant tissue samples collected and stored with the appropriate timing and conditions. These requirements are summarized. To conclude, a short discussion of future prospects is presented.

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Acknowledgements

Thanks to Derek Doherty and Emma Quinn for reading and commenting on this manuscript, and to Eleisa Heron for useful discussion. Anthony W. Ryan acknowledges funding from the Royal City of Dublin Hospital Trust.

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Authors and Affiliations

  1. Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland

    Graham D. Turner & Anthony W. Ryan

  2. Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James’s Hospital, Dublin, Ireland

    Graham D. Turner & Anthony W. Ryan

  3. National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin, Dublin, 12, Ireland

    Margaret R. Dunne

  4. Department of Immunology, Institute of Molecular Medicine, St James’s Hospital, Trinity College Dublin, Dublin, 8, Ireland

    Margaret R. Dunne

  5. Department of Surgery, Trinity Centre for Health Sciences, St James’s Hospital, Dublin, 8, Ireland

    Margaret R. Dunne

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  1. Graham D. Turner
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Correspondence to Anthony W. Ryan .

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  1. Trinity Centre for Health Sciences, Trinity College Dublin Trinity Centre for Health Sciences, Dublin, Ireland

    Anthony W. Ryan

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Turner, G.D., Dunne, M.R., Ryan, A.W. (2015). Celiac Disease: Background and Historical Context. In: Ryan, A. (eds) Celiac Disease. Methods in Molecular Biology, vol 1326. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2839-2_1

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  • DOI: https://doi.org/10.1007/978-1-4939-2839-2_1

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2838-5

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