Abstract
Repositioning of cell-specific Transcription Factor Regulatory Networks (TFRNs) into another cell type is a pragmatic approach to elicit desired functions in impaired cells and also to investigate transcription regulations underlying cellular functions. However, a systematic method to identify a set of transcription factors (TFs) which can efficiently promote TFRN in a foreign cell type is lacking. Here, we demonstrate a perturbation-matrix method for the identification and repositioning of monocyte TFRNs in dermal fibroblasts.
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Acknowledgement
This work was supported by MEXT grants for RIKEN Omics Science Center and Center for Life Science Technologies.
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Suzuki, T., Shin, J.W., Suzuki, H. (2014). Repositioning Monocyte TFRN into Fibroblasts. In: Miyamoto-Sato, E., Ohashi, H., Sasaki, H., Nishikawa, Ji., Yanagawa, H. (eds) Transcription Factor Regulatory Networks. Methods in Molecular Biology, vol 1164. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0805-9_17
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DOI: https://doi.org/10.1007/978-1-4939-0805-9_17
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-0804-2
Online ISBN: 978-1-4939-0805-9
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