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Unusual Thyroid Tumors

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Atlas of Endocrine Pathology

Part of the book series: Atlas of Anatomic Pathology ((AAP))

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Abstract

A variety of unusual tumors involve the thyroid, including sclerosing mucoepidermoid carcinoma with eosinophils, which has an unusual appearance with infiltrating glandular cells and squamoid cells. Squamous cell carcinoma may involve the thyroid by direct extension from a tumor in the neck or as a metastasis, but primary squamous cell carcinomas of the thyroid also occur. Malignant lymphoma may be primary to the thyroid, or the thyroid may be affected in systemic disease. When limited to the thyroid, Langerhans cell histiocytosis tends to be quite indolent and to remain localized. A variety of mesenchymal tumors affect the thyroid, including solitary fibrous tumor, angiosarcoma, synovial sarcoma, leiomyosarcoma, low-grade fibromyxoid sarcoma, and rhabdomyosarcoma, but angiosarcomas are among the most common and most aggressive sarcomas affecting the thyroid.

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References

  1. Baloch ZW, Solomon AC, LiVolsi VA. Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases. Mod Pathol. 2000;13(7):802–7.

    Article  CAS  PubMed  Google Scholar 

  2. Cavazza A, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: description of a case. Pathologica. 1999;91(1):31–5.

    CAS  PubMed  Google Scholar 

  3. Chan JK, et al. Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia. A distinctive low-grade malignancy arising from the metaplastic follicles of Hashimoto’s thyroiditis. Am J Surg Pathol. 1991;15(5):438–48.

    Article  CAS  PubMed  Google Scholar 

  4. DeLellis RA, Lloyd RV, Heitz PU. WHO classification of tumours—pathology and genetics. In: DeLellis RA, Lloyd RV, Heitz PU, editors. Tumours of endocrine organs. Lyon: IARC Press; 2004.

    Google Scholar 

  5. Lam KY, Lo CY, Liu MC. Primary squamous cell carcinoma of the thyroid gland: an entity with aggressive clinical behaviour and distinctive cytokeratin expression profiles. Histopathology. 2001;39(3):279–86.

    Article  CAS  PubMed  Google Scholar 

  6. Cook AM, Vini L, Harmer C. Squamous cell carcinoma of the thyroid: outcome of treatment in 16 patients. Eur J Surg Oncol. 1999;25(6):606–9.

    Article  CAS  PubMed  Google Scholar 

  7. Lam KY, et al. Insular and anaplastic carcinoma of the thyroid: a 45-year comparative study at a single institution and a review of the significance of p53 and p21. Ann Surg. 2000;231(3):329–38.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Booya F, et al. Primary squamous cell carcinoma of the thyroid: report of ten cases. Thyroid. 2006;16(1):89–93.

    Article  PubMed  Google Scholar 

  9. Sanchez-Sosa S, et al. Primary squamous cell carcinoma of the thyroid arising in Hashimoto’s thyroiditis in an adolescent. Pediatr Dev Pathol. 2006;9(6):496–500.

    Article  PubMed  Google Scholar 

  10. Kleer CG, Giordano TJ, Merino MJ. Squamous cell carcinoma of the thyroid: an aggressive tumor associated with tall cell variant of papillary thyroid carcinoma. Mod Pathol. 2000;13(7):742–6.

    Article  CAS  PubMed  Google Scholar 

  11. Katoh R, et al. Squamous differentiation in thyroid carcinoma. With special reference to histogenesis of squamous cell carcinoma of the thyroid. Acta Pathol Jpn. 1989;39(5):306–12.

    CAS  PubMed  Google Scholar 

  12. Derringer GA, et al. Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases. Am J Surg Pathol. 2000;24(5):623–39.

    Article  CAS  PubMed  Google Scholar 

  13. Thompson LD, et al. Langerhans cell histiocytosis of the thyroid: a series of seven cases and a review of the literature. Mod Pathol. 1996;9(2):145–9.

    CAS  PubMed  Google Scholar 

  14. Cameselle-Teijeiro J, et al. Lipomatous hemangiopericytoma of the thyroid. Pathologica. 2002;94:74.

    Google Scholar 

  15. Deshmukh NS, et al. Solitary fibrous tumour of the thyroid gland. J Laryngol Otol. 2001;115(11):940–2.

    Article  CAS  PubMed  Google Scholar 

  16. Hedinger C. Geographic pathology of thyroid diseases. Pathol Res Pract. 1981;171(3–4):285–92.

    Article  CAS  PubMed  Google Scholar 

  17. Eusebi V, et al. Keratin-positive epithelioid angiosarcoma of thyroid. A report of four cases. Am J Surg Pathol. 1990;14(8):737–47.

    Article  CAS  PubMed  Google Scholar 

  18. Mills SE, et al. Angiomatoid carcinoma and ‘angiosarcoma’ of the thyroid gland. A spectrum of endothelial differentiation. Am J Clin Pathol. 1994;102(3):322–30.

    CAS  PubMed  Google Scholar 

  19. Ryu CH, Cho KJ, Choi SH. Synovial sarcoma of the thyroid gland. Clin Exp Otorhinolaryngol. 2011;4(4):204–6.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Kikuchi I, et al. Synovial sarcoma of the thyroid. Report of a case with aspiration cytology findings and gene analysis. Acta Cytol. 2003;47(3):495–500.

    Article  PubMed  Google Scholar 

  21. Dong W, Zhang H. Low-grade fibromyxoid sarcoma of the thyroid: a case report. Ann Acad Med Singapore. 2013;42(1):55–6.

    PubMed  Google Scholar 

  22. Merchant SH. Low grade fibromyxoid sarcoma: report of a case with epithelioid cell morphology, masquerading as a papillary thyroid carcinoma. Acta Cytol. 2009;53(6):689–92.

    Article  PubMed  Google Scholar 

  23. Mertens F, et al. Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene. Lab Invest. 2005;85(3):408–15.

    Article  CAS  PubMed  Google Scholar 

  24. Carda C, et al. Anaplastic carcinoma of the thyroid with rhabdomyosarcomatous differentiation: a report of two cases. Virchows Arch. 2005;446(1):46–51.

    Article  PubMed  Google Scholar 

  25. Miyauchi A, et al. Intrathyroidal epithelial thymoma: an entity distinct from squamous cell carcinoma of the thyroid. World J Surg. 1985;9(1):128–35.

    Article  CAS  PubMed  Google Scholar 

  26. Dorfman DM, Shahsafaei A, Miyauchi A. Intrathyroidal epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE) exhibits CD5 immunoreactivity: new evidence for thymic differentiation. Histopathology. 1998;32(2):104–9.

    Article  CAS  PubMed  Google Scholar 

  27. Kakudo K, et al. Intrathyroid epithelial thymoma (ITET) and carcinoma showing thymus-like differentiation (CASTLE): CD5-positive neoplasms mimicking squamous cell carcinoma of the thyroid. Histol Histopathol. 2013;28(5):543–56.

    PubMed  Google Scholar 

  28. Reimann JD, Dorfman DM, Nose V. Carcinoma showing thymus-like differentiation of the thyroid (CASTLE): a comparative study: evidence of thymic differentiation and solid cell nest origin. Am J Surg Pathol. 2006;30(8):994–1001.

    Article  PubMed  Google Scholar 

  29. Thompson LD, Rosai J, Heffess CS. Primary thyroid teratomas: a clinicopathologic study of 30 cases. Cancer. 2000;88(5):1149–58.

    Article  CAS  PubMed  Google Scholar 

  30. Riedlinger WF, et al. Primary thyroid teratomas in children: a report of 11 cases with a proposal of criteria for their diagnosis. Am J Surg Pathol. 2005;29(5):700–6.

    Article  PubMed  Google Scholar 

  31. Brownlee RE, Shockley WW. Thyroid paraganglioma. Ann Otol Rhinol Laryngol. 1992;101(4):293–9.

    CAS  PubMed  Google Scholar 

  32. Buss DH, et al. Paraganglioma of the thyroid gland. Am J Surg Pathol. 1980;4(6):589–93.

    Article  CAS  PubMed  Google Scholar 

  33. Kronz JD, et al. Paraganglioma of the thyroid: two cases that clarify and expand the clinical spectrum. Head Neck. 2000;22(6):621–5.

    Article  CAS  PubMed  Google Scholar 

  34. Mitsudo SM, et al. Malignant paraganglioma of the thyroid gland. Arch Pathol Lab Med. 1987;111(4):378–80.

    CAS  PubMed  Google Scholar 

  35. Corrado S, et al. Primary paraganglioma of the thyroid gland. J Endocrinol Invest. 2004;27(8):788–92.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Mayo Clinic College of Medicine, Rochester, MN, USA

    Lori A. Erickson MD

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  1. Lori A. Erickson MD
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Erickson, L.A. (2014). Unusual Thyroid Tumors. In: Atlas of Endocrine Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0443-3_12

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  • DOI: https://doi.org/10.1007/978-1-4939-0443-3_12

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-0442-6

  • Online ISBN: 978-1-4939-0443-3

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