Abstract
Mice of the AKR strain have a very high incidence of lymphocytic neoplasms which appear to be caused by a vertically transmitted virus (see reviews by Kaplan, 1967; Moloney, 1962; Furth et al., 1964; Gross, 1958 and 1961). Since this agent is vertically transmitted, it is expected that germfree mice would also develop leukemia, unless the presence of a microbial flora, or other horizontally transmitted viruses, contribute to its development. That this is indeed the case has been demonstrated by Pollard and his co-workers (Pollard et al., 1966; Pollard, 1967) who showed that germfree AKR mice do develop leukemia in high incidence. The purpose of this paper is to compare the incidence of leukemia in germfree AKR mice with their conventional counterparts. We will also describe some of the characteristics of the germfree AKR mouse which make it somewhat different from other germfree inbred strains.
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References
Furth, J.; Okano, H.; Kunii, A. 1964 Role of the thymus in Leukemogenesis. In: The Thymus in Immunobiology; Structure, Function, and Role in Disease. Harper & Row, Publishers, New York.
Gross, L. 1958 Viral etiology of “spontaneous” mouse leukemia: A review. Cancer Research, 18:371–381.
Gross, L. 1961 Oncogenic Viruses. Pergamon Press, Publishers, New York.
Kaplan, H. S. 1967 On the natural history of the murine leukemias: Presidential address. Cancer Research, 27:1325–1340.
McEndy, D. P.; Boon, M. C; and Furth, J. 1944 The role of thymus, spleen, and gonads in the development of leukemia in a high-leukemia stock of mice. Cancer Research, 4:377–383.
Moloney, J. B. 1962 The murine leukemia. Fed. Proc., 21:19–31.
Pilgrim, H. I.; and Dowd, J. E. 1963 Correcting for extraneous death in the evaluation of morbidity or mortality from tumor. Cancer Research, 23:45–48.
Pilgrim, H. I.; and Thompson, D. B. 1962 An inexpensive, auto-clavable germfree mouse isolator. Lab. Animal Care, 13:602–608.
Pollard, M. 1967 Preleukemic syndrome in germfree AK mice. Nature, 123:142–144.
Pollard, M. ; Kajima, M. ; and Teah, B. A. 1965 Spontaneous leukemia in germfree AK mice. Proc. Soc. Exper. Biol. & Med., 120:72–75.
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Pilgrim, H.I., Parks, R.C., Law, L.W. (1969). Leukemia in Germfree AKR Mice. In: Mirand, E.A., Back, N. (eds) Germ-Free Biology Experimental and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6495-3_15
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DOI: https://doi.org/10.1007/978-1-4899-6495-3_15
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