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Genetics and Diabetic Nephropathy

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The Kidney and Hypertension in Diabetes Mellitus

Abstract

Diabetic nephropathy is an acquired condition due to the glomerular consequences of diabetic microangiopathy. Diabetic microangiopathy is secondary to lasting hyperglycaemia, as this was evidenced by experimental, follow-up and intervention clinical studies. However, the annual and cumulated incidences of diabetic nephropathy are lower than those of diabetic retinopathy or neuropathy [1]. For instance, Pirart [2] reported that among type 1 insulin-dependent patients developing diabetic nephropathy, 86% already ha diabetic retinopathy and 89% diabetic neuropathy, while 61% of those developing diabetic retinopathy already had diabetic neuropathy, but only 24% already had diabetic nephropathy (figure 5-1). Thus, diabetes duration and control are necessary and sufficient conditionals for diabetic retinopathy to develop, while those conditionals are necessary but not sufficient for diabetic nephropathy to develop. Consequently, factors protecting against renal complications due to uncontrolled diabetes must be studied, because their identification may held establishing prognosis of type 1, insulin-dependent diabetic patients and perhaps some peculiar follow-up and treatment strategies.

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Authors and Affiliations

  1. Service de Médecine B, Centre Hospitalier Universitaire, Angers, France

    Michel Marre

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  1. Michel Marre
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  1. Medical Department M (Diabetes & Endocrinology), Aarhus Kommunehospital University Hospitals in Aarhus, Aarhus C, Denmark

    Carl Erik Mogensen

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Marre, M. (1996). Genetics and Diabetic Nephropathy. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6749-0_5

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  • DOI: https://doi.org/10.1007/978-1-4757-6749-0_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6751-3

  • Online ISBN: 978-1-4757-6749-0

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