Skip to main content

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 252))

  • 163 Accesses

Abstract

Uric acid is the end product of purine metabolism in humans. In animals other than mammals uric acid undergoes further degradation because of the activity of enzymes such as uricase, allantoinase and allantoinase; in some species the urea that is formed is further hydrolyzed to ammonia and CO2 by the urease of intestinal bacteria (1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. N.A. Breslau and K. Sakhaee, Pathophysiology of nonhypercalciuric causes of stones. in: “Renal Stone Disease”, C.Y.C. Pak, ed., Martinus Nijhoff Publishing, Boston (1987), pp. 47–84.

    Chapter  Google Scholar 

  2. E.W. Holmes, Uric acid nephrolithiasis, in: “Nephrolithiasis”, F.L. Coe, ed., Churchill Livingstone, New York (1972), pp. 325–336.

    Google Scholar 

  3. L.B. Sorensen, Role of the intestinal tract in the elimination of uric acid, Arth. Rheum. 8: 994 (1965).

    Article  Google Scholar 

  4. L.B. Sorensen, Extrarenal disposal of uric acid. in: “Uric acid”, W.N. Kelley and I.N. Weiner, eds., Springer-Verlag, New York (1978), pp. 325–336.

    Chapter  Google Scholar 

  5. A. Atsmon, A. DeVries and M. Frank, “Uric Acid Lithiasis”, Elsevier, Amsterdam (1963).

    Google Scholar 

  6. A. Bollinger and R. Gross, Ammonia, urea and uric acid content of toe nails in renal insufficiency and gout, Aust. Exp . Biol. Med. Sci. 31: 385 (1953).

    Article  Google Scholar 

  7. V.E. Andreucci, “Acute Renal Failure”, Martinus Nijhoff Publishing, Boston (1984).

    Book  Google Scholar 

  8. J.D. Conger, S.A. Falk, S.J. Guggenheim and T.J. Burke, A micropuncture study of the early phase of acute urate nephropathy, J. Clint Invest. 58: 681 (1976).

    Article  CAS  Google Scholar 

  9. J.D. Conger and S.A. Falk, Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy, J. Clin. Invest. 59: 786 (1977).

    Article  PubMed  CAS  Google Scholar 

  10. R.E. Rieselbach, C.J. Benzel, E. Cotlove, E. Frei and E.J. Freireich, Uric acid excretion and renal function in the acute hyperuricemia of leukemia. Am. J. Med. 37: 872 (1964).

    Article  PubMed  CAS  Google Scholar 

  11. J. Kelton, W.N. Kelley and E.W. Holmes, A rapid method for the diagnosis of acute uric acid nephropathy. Arch. Intern. Med. 138: 612 (1978).

    Article  PubMed  CAS  Google Scholar 

  12. B. Finlayson and A. Smith, Stability of first dissociable proton of uric acid, J. Chem. Eng. Data, 19: 94 (1974).

    Article  CAS  Google Scholar 

  13. F.L. Coe, A.L. Stauss, V. Tembe and M.S.L. Dunn, Uric acid saturation in calcium nephrolithiasis, Kidnev Int. 17: 661 (1980).

    Google Scholar 

  14. C.Y.C. Pak, N.A. Breslau and J.A. Harvey, Nutrition and metabolic bone disease, in: “Nutritional Diseases: Research Directors in Comparative Pathobiology”, D.G. Scarpelli and G. Migaki, eds., Alan R. Liss, New York (1986) pp 115–140.

    Google Scholar 

  15. C.Y.C. Pak, “Renal Stone Disease”, Martinus Nijhoff Publishing, Boston (1987).

    Book  Google Scholar 

  16. C.Y.C. Pak, D.E. Barilla, K. Holt, L. Brinkley, R. Tolentino and J.E. Zerwekh, Effect of oral purine load and allopurinol on the crystallization of calcium salts in urine of patients with hyperuricosuric calcium urolithiasis. Am. J. Med. 65: 593 (1978).

    Article  PubMed  CAS  Google Scholar 

  17. F.L. Coe and A.G. Kavalach, Hypercalciuria and hyperuricosuria in patients with calcium nephrolithiasis, N. Eng. J. Med. 291: 1344 (1974).

    Article  CAS  Google Scholar 

  18. C.Y.C. Pak, O. Waters, L. Arnold, K. Holt, C. Cox and D.E. Barilla, Mechanism of calcium urolithiasis among patients with hyperuricosuria: supersaturation of urine with respect to monosodium urate, J. Clin. Invest. 59: 426 (1977).

    Article  PubMed  CAS  Google Scholar 

  19. C.Y.C. Pak and L. Arnold, Heterogeneous nucleation of calcium oxalate by seeds of monosodium urate, Proc. Soc. Exp . Biol. Med. 149: 930 (1975).

    PubMed  CAS  Google Scholar 

  20. F.L. Coe, R.L. Lawton, R.B. Goldstein and V. Tembe, Sodium urate accelerates precipitation of calcium oxalate in vitro, Proc. Soc. Exp. Biol. Med. 149: 926 (1975).

    PubMed  CAS  Google Scholar 

  21. C.Y.C. Pak, K. Holt and J.E. Zerwekh, Attenuation by monosodium urate of the inhinitory effect of mucopolysaccharide on calcium oxalate nucleation. Invest. Urol. 17: 138 (1979).

    PubMed  CAS  Google Scholar 

  22. C.M. Kjellstrand, D.C.H. Campbell, B. von Hartitzsch and T.J. Bus1meier, Hyperuricemic acute renal failure, Arch. Intern. Med. 133: 349 (1974).

    Article  PubMed  CAS  Google Scholar 

  23. J.O. Wool Iiscroft, H. Colfer and I.H. Fox, Hyperuricemia in acute illness: a poor prognostic sign, Am. J. Med. 72: 58 (1982).

    Article  Google Scholar 

  24. L.H. Beck, Requiem for gouty nephropathy, Kidnev Int., 30: 280 (1986).

    Article  CAS  Google Scholar 

  25. J.M. Charcot, Clinical lectures on senile and chronic diseases. Translated by W.S. Tuke, The New Sydenham Society, London (1881).

    Google Scholar 

  26. R.P. Wedeen and V. Batuman, Tubulo-interstitial nephritis induced by heavy metals and metabolic disturbances, in: “Tubulo-interstitial nephropathies”, R.S. Cotran, ed., Churchill Livingstone, New York (1983) pp. 211–241.

    Google Scholar 

  27. W.J. Fessel, Renal outcomes of gout and hyperuricemia. Am. J. Med. 67: 74 (1979).

    Article  PubMed  CAS  Google Scholar 

  28. T.F. Yu, T.L. Berger, D.J. Dorph and H. Smith, Renal function in gout. V. Factors influencing the renal hemodynamics. Am. J. Med. 67: 766 (1979).

    Article  PubMed  CAS  Google Scholar 

  29. T.F. Yu and T.L. Berger, Renal disease in primary gout: a study of 259 gout patients with proteinuria, Semin. Arthritis Rheum., 4: 293 (1975).

    Article  PubMed  CAS  Google Scholar 

  30. T.L. Berger and T.F. Yu, Renal function in gout. IV. An analysis of 524 gouty subjects including long-term follow-up studies. Am. J. Med. 59: 605 (1975).

    Article  PubMed  CAS  Google Scholar 

  31. T.F. Yu and T.L. Berger, “The kidney in gout and hyperuricemia”, Futura Publishing, Mount Kisco, NY (1982).

    Google Scholar 

  32. R.L. Wortmann and I.H. Fox, Limited value of uric acid to creatinine ratios in estimating uric acid excretion, Ann. Intern. Med. 93: 822 (1980).

    PubMed  CAS  Google Scholar 

  33. C.Y.C. Pak, Prevention of recurrent nephrolithiasis, in: “Renal Stone Disease”, C.Y.C. Pak, ed., Martinus Nijhoff Publishing, Boston (1987).

    Chapter  Google Scholar 

  34. N.A. Breslau, K. Sakhaee, C. Crowther and L. Brinkley, Evidence justifying a high fluid intake in treatment of nephrolithiasis, Ann. Intern, Med. 93: 36 (1981).

    Google Scholar 

  35. C.Y.C. Pak and R. Peterson, Successful treatment of hyperuricosuric calcium oxalate nephrolithiasis with potassium citrate, Arch. Intern. Med. 146: 863 (1986).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Fuiano, G., Federico, S., Conte, G., Andreucci, V.E. (1989). Uric Acid and Kidney. In: Amerio, A., Coratelli, P., Campese, V.M., Massry, S.G. (eds) Drugs, Systemic Diseases, and the Kidney. Advances in Experimental Medicine and Biology, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8953-8_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8953-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8955-2

  • Online ISBN: 978-1-4684-8953-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics