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Life and Death of a T Cell

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Mechanisms of Lymphocyte Activation and Immune Regulation III

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 292))

Abstract

Thymus-derived lymphocytes or T cells recognize nominal antigens in the context of the products of the self major histocompatibility locus (MHC)--a phenomenon called MHC restriction. In addition, T cells must be self-tolerant to antigens that are endogenous to the organism in order to avoid an autoimmune condition. How the developing T cells acquire these two characteristics is the main theme of my laboratory.

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References

  1. W. C. Sha, C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh, Selective expression of an antigen receptor on CD8-bearing T lymphocytes in trans-genic mice, Nature 335:271 (1988).

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  2. W. C. Sha, C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh, Positive and negative selection of an antigen receptor on T cells in transgenic mice, Nature 336:73 (1988).

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  3. W. C. Sha, C. A. Nelson, R. D. Newberry, J. K. Pullen, L. R. Pease, J. H. Russell, and D. Y. Loh, Positive selection of transgenic receptor-bearing thymocytes by Kb mutations that involve peptide binding, Proc. Natl. Aca. Sci. USA (in press, 1990).

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Department of Medicine, Genetics, Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

    Dennis Y. Loh

Authors
  1. Dennis Y. Loh
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of California, Irvine, California, 92717, USA

    Sudhir Gupta

  2. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    William E. Paul

  3. The Howard Hughes Medical Institute, University of Alabama, Birmingham, Alabama, 35294, USA

    Max D. Cooper

  4. Department of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Ellen V. Rothenberg

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© 1991 Plenum Press, New York

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Loh, D.Y. (1991). Life and Death of a T Cell. In: Gupta, S., Paul, W.E., Cooper, M.D., Rothenberg, E.V. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation III. Advances in Experimental Medicine and Biology, vol 292. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5943-2_5

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  • DOI: https://doi.org/10.1007/978-1-4684-5943-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5945-6

  • Online ISBN: 978-1-4684-5943-2

  • eBook Packages: Springer Book Archive

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