Skip to main content
SpringerLink
Log in

Life and Death of a T Cell

  • Chapter
Mechanisms of Lymphocyte Activation and Immune Regulation III

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 292))

  • 95 Accesses

Abstract

Thymus-derived lymphocytes or T cells recognize nominal antigens in the context of the products of the self major histocompatibility locus (MHC)--a phenomenon called MHC restriction. In addition, T cells must be self-tolerant to antigens that are endogenous to the organism in order to avoid an autoimmune condition. How the developing T cells acquire these two characteristics is the main theme of my laboratory.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. W. C. Sha, C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh, Selective expression of an antigen receptor on CD8-bearing T lymphocytes in trans-genic mice, Nature 335:271 (1988).

    Article  PubMed  CAS  Google Scholar 

  2. W. C. Sha, C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Russell, and D. Y. Loh, Positive and negative selection of an antigen receptor on T cells in transgenic mice, Nature 336:73 (1988).

    Article  PubMed  CAS  Google Scholar 

  3. W. C. Sha, C. A. Nelson, R. D. Newberry, J. K. Pullen, L. R. Pease, J. H. Russell, and D. Y. Loh, Positive selection of transgenic receptor-bearing thymocytes by Kb mutations that involve peptide binding, Proc. Natl. Aca. Sci. USA (in press, 1990).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Department of Medicine, Genetics, Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

    Dennis Y. Loh

Authors
  1. Dennis Y. Loh
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Medicine, University of California, Irvine, California, 92717, USA

    Sudhir Gupta

  2. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    William E. Paul

  3. The Howard Hughes Medical Institute, University of Alabama, Birmingham, Alabama, 35294, USA

    Max D. Cooper

  4. Department of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Ellen V. Rothenberg

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

Loh, D.Y. (1991). Life and Death of a T Cell. In: Gupta, S., Paul, W.E., Cooper, M.D., Rothenberg, E.V. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation III. Advances in Experimental Medicine and Biology, vol 292. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5943-2_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5943-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5945-6

  • Online ISBN: 978-1-4684-5943-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation