Abstract
We report a case of 62-year-old Japanese male with a myelodysplastic syndrome (MDS) with a Philadelphia (Ph) chromosome. Cytogenetic analysis revealed the bone marrow cells to contain a Ph chromosome due to t(?;11;22) (?;q11;q11), as well as −5, −7, +8, −12 and an extra Ph, in addition to cells with a normal karyotype. Molecular analysis using breakpoint cluster region probes (5′ bcr and 3′ bcr) did not detect a rearrangement within the bcr DNA sequences, indicating that the breakpoint at 22q11 occurred outside the bcr. Furthermore, the bone marrow cells from this patient did not express an 8.5 kb c-abl mRNA. Thus, the Ph translocation in this case differs from that of Ph-positive chronic myelogenous leukemia.
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References
Sandberg, A.A., 1980. The chromosomes in Human Cancer and Leukemia Elsevier/North-Holland Inc., New York.
Canellos, G.P., and J. Whang-Peng. 1972. Philadelphia-chromosome-positive preleukemic state. Lancet i. 1227–1228.
Gracy, M., Suharjono, Sunoto. 1980. Myelomonocytic leukaemia with a preleukemic syndrome and ph-*- chromosome in monozygotic twins. Arch. Dis. Child. 52: 72–80.
Roth, D.G., C.M. Tichman, and J.D. Rowley. 1980. Chronic myelodysplastic syndrome (preleukemia) with the Philadelphia chromosome Blood 56: 262–264.
Michalske, K.A., J.H. Miles, and M.C. Perry. 1982. Unusual Ph translocation in preleukemia. Cancer Genet Cytogenet. 6: 89–90.
Ohyashiki, K., J.H. Ohyashiki, A. Raza, H.D. Preisler, and A.A. Sandberg. 1987. Phenylbutazone-induced myelodysplastic syndrome with Philadelphia translocation. Cancer Genet Cytogenet. 26: 213–216.
Ohyashiki, K., J.H. Ohyashiki, A.J. Kinniburgh, J. Rowe, K.B. Miller, A. Raza, H.D. Preiler, and A.A. Sandberg. 1987. Transposition of breakpoint cluster region (3’bcr) in CML cells with variant Philadelphia translocations. Cancer Genet Cytogenet. 26: 105–115.
Stam, K., N. Heisterkamp, G. Grosveld, A. de Klein, B.S. Verma, M.Cleman, H. Dosck, and J. Groffen. 1985. Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome. N. Engl. J. Med. 313: 1429–1433.
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© 1988 Plenum Press, New York
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Keisuke, T., Kazuma, O., Junko, H.O. (1988). Molecular Implications of Ph (+) Myelodysplastic Syndrome. In: Tavassoli, M., Zanjani, E.D., Ascensao, J.L., Abraham, N.G., Levine, A.S. (eds) Molecular Biology of Hemopoiesis. Advances in Experimental Medicine and Biology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5571-7_10
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DOI: https://doi.org/10.1007/978-1-4684-5571-7_10
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