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Effects of Long-Term Neuroleptic Treatment on Serum Levels of Prolactin, TSH, LH, and Norepinephrine and on α-Adrenergic and Dopaminergic Receptor Sensitivity

Relations to Tardive Dyskinesia

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Psychoneuroendocrine Dysfunction

Abstract

Neuroendocrine effects of catecholamine receptor-blocking neuroleptic drugs have been investigated in numerous studies (Ackenheil, 1981; Brambilla et al., 1979a; Burt et al., 1977; Carlsson, 1978, Collu et al., 1977; Ettigi et al., 1976; Meltzer et al., 1978; Pandey et al., 1977; Sachar, 1978); in particular, the increase of serum prolactin (PRL) after acute neuroleptic treatment is well documented (Gruen et al., 1978; Langer et al., 1977; Rubin and Hays, 1980, Wode-Helgodt, et al., 1977). There are, however, only a few studies dealing with the neuroendocrine effects of chronic neuroleptic treatment. As both differ distinctly, inferring long-term effects from short-term effects is inappropriate (Ler-ner et al., 1977). Moreover, there are striking differences in the reactivity of the tuberoinfundibular, nigrostrial, mesolimbic, and mesocortical dopaminergic systems to long-term treatment with neuroleptics (Bowers and Rozitis, 1974; Julou et al., 1977).

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  1. Psychiatric Hospital of the University of Munich, Munich, Germany

    Dieter Naber & Franz Müller

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  1. Dieter Naber
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  1. Ensor Foundation Research Laboratory, William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) (Director, Research Professor)

  2. Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) & Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Research Professor) &  (Director, Professor and Chairman)

  3. William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Professor and Chairman)

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Naber, D., Müller, F. (1984). Effects of Long-Term Neuroleptic Treatment on Serum Levels of Prolactin, TSH, LH, and Norepinephrine and on α-Adrenergic and Dopaminergic Receptor Sensitivity. In: Shah, N.S., Donald, A.G. (eds) Psychoneuroendocrine Dysfunction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4529-9_34

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  • DOI: https://doi.org/10.1007/978-1-4684-4529-9_34

  • Publisher Name: Springer, Boston, MA

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