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Fatty Acid Metabolism

  • Chapter
Fungal Lipid Biochemistry

Part of the book series: Monographs in Lipid Research ((MLR))

Abstract

Our knowledge of fatty acid metabolism in fungi as well as all other major groups of living organisms exceeds that of any other lipid class. In the late 1800’s the first studies on lipid metabolism were concerned with the degradation of fatty acids in animals. It was shown that fatty acids fed to animals were oxidized, and large quantities of acetic acid were excreted in the urine. In his now classical experiments reported in 1904, Knoop fed phenyl derivatives of fatty acids (the phenyl group attached at the terminal carbon) to dogs and examined the urine for degradation products containing the phenyl group. He found that the oxidation of even-numbered fatty acids led to the accumulation of phenylacetic acid, or a glycine conjugate, in the urine. This led Knoop to propose that fatty-acid degradation is accomplished through the successive removal of C2 units, and the β-oxidation theory of fatty-acid catabolism was developed.

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  1. Department of Botany and Microbiology, Auburn University, Auburn, Alabama, USA

    John D. Weete

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© 1974 Plenum Press, New York

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Weete, J.D. (1974). Fatty Acid Metabolism. In: Fungal Lipid Biochemistry. Monographs in Lipid Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2829-2_4

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