Abstract
In recent years, a number of drug radioimmunoassays (RIA’s) have been developed. Some of these can be purchased as complete kits while, for others, the items required must be obtained separately either from commercial sources or from the individuals who developed the assays. At present, sufficient assays are available to provide a reasonably comprehensive drug-screen, and those used in the Metropolitan Police Forensic Science Laboratory are shown in Table 1. Virtually all the toxicological and Road Traffic Act cases submitted for drugs analysis (currently about 600 per year) are analysed in part by RIA, the assays required for each case being selected by the person in charge of the case. In the first six months of this year, 310 cases totalling 435 items were analysed by RIA and 978 assay results were obtained. The number of assay results per case ranged from 1 to 10, and one or more positive results were obtained in about 50% of the cases. The average “turnaround” time per case was about one week.
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References
Desbuquois, B. and Aurbach, G.D. (1971), “Use of polyethylene glycol to separate free and antibody-bound hormones in radioimmunoassays”. J. Clin. Endocr. Metab., 33, 732–738
Fletcher, S.M., Lawson, G.J. and Moffat, A.C. (1977), “The radioimmunoassay of cardiac clycosides in normal and post mortem blood”. Home Office Central Research Establishment Report No. 255
Gennaro, W.D. and van Norman, J.D. (1975), “Quantitation of free, total and antibody-bound insulin in insulin-treated diabetics”. Clin. Chem., 21, 873–879
Reding, L.G. (1969), “Determination of free and antibody-bound insulin in insulin treated diabetic patients”. Norm. Metab. Res., 1, 145–146
Holt, D.W. and Benstead, J.G. (1975), “Postmortem assay of digoxin by radioimmunoassay”. J. Clin. Path., 28, 483–486
Karjalainen, J., Ojala, K. and Reissell, P. (1974), “Tissue concentrations of digoxin in autopsy material”. Acta Pharmacol. Toxicol., 34, 385–390
Maguire, K.P., Burrows, G.D., Norman, T.R. and Scoggins, B.A. (1978) “A radioimmunoassay for nortriptyline (and other tricyclic antidepressants) in plasma”. Clin. Chem., 24, 549–554
Ratcliffe, W.A., Fletcher, S.M., Moffat, A.C., Ratcliffe, J.G., Harland, W.A., and Levitt, T.E. (1977), “Radioimmunoassay of lysergic acid diethylamide (LSD) in serum and urine using antisera of different specificities”. Clin. Chem., 23, 169–174
Robinson, J.D., Risby, D., Riley, G., and Aherne, G.W. (1978), “A radioimmunoassay for the determination of combined amitriptyline and nortriptyline concentrations in microliter samples of plasma”. J. Pharm. Expt. Therap, 205, 499–502
Teale, J.D., Forman, E.J., King, L.J., Piall, E.M. and Marks, V. (1975) “The development of a radioimmunoassay for cannabinoids in blood and urine”. J. Pharm. Pharmac., 27, 465–472
Williams, P.L. (1978), “The detection and quantification of cannabinoids and their metabolites in body fluids”. Ph.D. Thesis, University of Surrey
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© 1980 International Association of Forensic Toxicologists
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Smith, R.N. (1980). Immunoassays in Forensic Toxicology. In: Oliver, J.S. (eds) Forensic Toxicology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1478-3_4
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DOI: https://doi.org/10.1007/978-1-4684-1478-3_4
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