Abstract
Changes in membrane composition and fluidity may reflect derangements in cellular functions. In plasma membranes (p.m.’s) they can modulate adenylate cyclase activity [1, 2]. Differences in both composition and physicochemical state could be demonstrated when comparing thyroid p.m.’s obtained (method as in [3]) from patients with normal thyroid and patients with multinodular goiter euthyroid gland. Normal thyroid membranes displayed higher protein-to-phospholipid ratios and a lower 5’-nucleotidase specific activity (expts. in triplicate on 1 goiter and 2 normal thyroid p.m. preparations; ±S.E.M.’s):
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protein:phospholipid (w/w): normal, 8.59 ±0.41; goiter, 4.26 ±0.15;
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cholesterol:phospholipid (molar ratio basis): normal, 0.69 ±0.08; goiter, 0.38 ±0.03;
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5’-nucleotidase (nmol/min/mg protein): normal, 8.3; goiter, 18.4.
An Addendum outlines lectin specificities (at Editors’ suggestion).
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© 1987 Plenum Press, New York
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Depauw, H. et al. (1987). The Glycoproteins and Fluidity of Multinodular Goiter Euthyroid Plasma Membranes. In: Reid, E., Cook, G.M.W., Luzio, J.P. (eds) Cells, Membranes, and Disease, Including Renal. Methodological Surveys in Biochemistry and Analysis, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1283-3_24
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DOI: https://doi.org/10.1007/978-1-4684-1283-3_24
Publisher Name: Springer, Boston, MA
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