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Inhibition of Malignant Tumor Cell Invasion: An Approach to Anti-Progression

  • Chapter
Antimutagenesis and Anticarcinogenesis Mechanisms III

Part of the book series: Basic Life Sciences ((BLSC,volume 61))

Abstract

Considerable attention should be given to primary prevention of neoplastic transformation. The best approaches to anticarcinogenesis are preventative measures to reduce exposure to environmental pollutants and improving life styles that may be responsible for genetic and epigenetic cell damage. Once neoplastic transformation has occurred, however, the major target of the oncologist becomes hindering tumor progression. It is difficult to define the onset of tumor progression and whether it involves a continous evolution or a step-like process. It is easier to define the consequence of tumor progression: malignant lesions with the ability to invade and to metastasize to distant organs. While benign tumors can often be cured simply by surgical removal, metastases remain the most frequent cause of cancer mortality.

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  1. Istituto Nazionale per la Ricerca sul Cancro, 16132, Genova, Italy

    Adriana Albini & Annamaria Colacci

  2. Biotechnology Satellite Unit, Istituto Nazionale per la Ricerca sul Cancro, 40126, Bologna, Italy

    Adriana Albini & Annamaria Colacci

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  1. Istituto di Mutagenesi e Differenziamento del CNR, Pisa, Italy

    Giorgio Bronzetti

  2. Okayama University, Okayama, Japan

    Hikoya Hayatsu

  3. Istituto di Igiene e Medicina Preventia, Genova, Italy

    Silvio De Flora

  4. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Michael D. Waters

  5. University of Kansas, Lawrence, Kansas, USA

    Delbert M. Shankel

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© 1993 Springer Science+Business Media New York

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Albini, A., Colacci, A. (1993). Inhibition of Malignant Tumor Cell Invasion: An Approach to Anti-Progression. In: Bronzetti, G., Hayatsu, H., De Flora, S., Waters, M.D., Shankel, D.M. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms III. Basic Life Sciences, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2984-2_32

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  • DOI: https://doi.org/10.1007/978-1-4615-2984-2_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6299-9

  • Online ISBN: 978-1-4615-2984-2

  • eBook Packages: Springer Book Archive

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