Abstract
Thyroid hormone-induced increases in oxygen consumption and heat production are consistent properties of many mammalian tissues including the liver. Hepatocytes from hypothyroid rats respire more slowly than those from control animals; cells from hyperthyroid rats respire faster. In liver mitochondria there are two major effects of thyroid hormones on oxygen consumption -one occurs in State 3 respiration where ATP turnover is increased1 and the other occurs in State 4 respiration where there is an increase in the leak of protons across the inner mitochondrial membrane2.
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References
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© 1993 Springer Science+Business Media New York
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Harper, ME., Brand, M.D. (1993). Mechanisms of the Effects of Hypothyroidism and Hyperthyroidism in Rats on Respiration Rate in Isolated Hepatocytes. In: Schuster, S., Rigoulet, M., Ouhabi, R., Mazat, JP. (eds) Modern Trends in Biothermokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2962-0_55
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DOI: https://doi.org/10.1007/978-1-4615-2962-0_55
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