Abstract
The endometrium responds to blastocyst signals by decidualization and placentation. Angiogenesis — new blood vessel formation — is considered to be a prerequisite for the development of the vascular placenta (Folkman and Shing, 1992). Pharmacological modulation of angiogenesis in the uterus would be of interest for e.g. (1) stimulation of placentation in infertile women during an in vitro-fertilization programme, (2) stimulation of placentation in pregnacies with an intrauterine growth-retarded baby, (3) inhibition of placentation as a contraceptive, and (4) inhibition of angiogenesis in endometrial cancers. In order to stimulate or inhibit endometrial angiogenesis, it is important that the formation of the vascular part of the placenta during normal pregnancy be investigated.
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Christofferson, R.H.B., Wassberg, B.E., Nilsson, B.O. (1994). Angiogenesis in the Rat Uterus During Pregnancy. In: Glasser, S.R., Mulholland, J., Psychoyos, A. (eds) Endocrinology of Embryo-Endometrium Interactions. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1881-5_8
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DOI: https://doi.org/10.1007/978-1-4615-1881-5_8
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