Abstract
There has been great confusion about the name of this stage of women’s health and reproductive lives, with vagueness to the term menopause, and the introduction of the stage of perimenopause, or premenopause, as something that doctors, and women, are starting to understand on its own. It is helpful to divide menopause into the stages of perimenopause and postmenopause, as women may experience different symptoms during these times, and clinicians may prescribe differently, based on symptoms and on the results of clinical studies and trials of HT efficacy and safety.
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Bibliography
Broer SL, Eijkemans JC, Scheffer GJ, et al. Anti-müllerian hormone predicts menopause: a long-term follow-up study in normoovulatory women. J Clin Endocrinol Metab. 2011;96(8):2532–9.
Crawford S, Santoro N, Laughlin GA, et al. Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition. J Clin Endocrinol Metab. 2009;94(8):2945–51.
Do Choi S, Steinberg EM, Hyeog Lee H, Naftolin F. The timing hypothesis remains a valid explanation of differential cardioprotective effects of menopausal hormone treatment [review article]. Menopause. 2011;18(2):230–6.
Freeman EW, Sammel MD, Lin H, Gracia CR. Anti-mullerian hormone as a predictor of time to menopause in late reproductive age women. J Clin Endocrinol Metab. 2012;97(5):1673–80.
Freeman WE, Sherif K. Prevalence of hot flushes and night sweats around the world: a systematic review. Climacteric. 2007;10:197–214.
Gast G-C M, Grobbee DE, Pop VJM, et al. Menopausal complaints are associated with cardiovascular risk factors. Hypertension. 2008;51(6):1492–8.
Gavin KM, Seals DR, Silver AE, Moreau KL. Vascular endothelial estrogen receptor alpha is modulated by estrogen status and related to endothelial function and eNOS in healthy women. J Clin Endocrinol Metab. 2009;94(9):3513–20.
Harlow SD, Gass M, Hall JE, et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab. 2012;97(4):1159–68.
Harlow SD, Gass M, Hall JE, et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Menopause. 2012;19(4):387–95.
Hunter MS, Gentry-Maharaj A, Ryan A, et al. Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross-sectional cohort study of 10 418 British women aged 54–65. BJOG. 2012;119(1):40–50.
Kok HS, van Asselt KM, van der Schouw YT, et al. Heart disease risk determines menopausal age rather than the reverse. J Am Coll Cardiol. 2006;47(10): 1976–83.
Konhilas JP, Leinwand LA. The effects of biological sex and diet on the development of heart failure. Circulation. 2007;116:2747–59.
Livingstone C, Collison M. Sex steroids and insulin resistance [review]. Clin Sci. 2002;102:151–66.
National Osteoporosis Foundation. 8 Common myths about osteoporosis. Washington, DC: National Osteoporosis Foundation; 2002.
Niland P, Lyons AC. Uncertainty in medicine: meanings of menopause and hormone replacement therapy in medical textbooks. Soc Sci Med. 2011;73:1238–45.
Notelovitz M. The clinical practice impact of the Women’s Health Initiative: political vs biological correctness [guest editorial]. Maturitas. 2003;44:3–9.
Notelovitz M. The biological rationale for estrogen therapy. Presented at 25 April 2003, Adult Women’s Health & Medicine meeting, Boca Raton, FL and Washington, DC.
O’Connor KA, Ferrell R, Brindle E, et al. Progesterone and ovulation across stages of the transition to menopause. Menopause. 2009;16(6):1178–87.
Phillips LS, Langer RD. Postmenopausal hormone therapy: critical reappraisal and a unified hypothesis. Fertil Steril. 2005;83(3):558–66.
Prior JC, Hitchcock CL. The endocrinology of perimenopause: need for a paradigm shift. Front Biosci. 2011;S3:474–86.
Rybaczyk LA, Bashaw MJ, Pathak DR, et al. An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology. BMC Womens Health. 2005;5:12.
Salpeter SR, Walsh JME, Greyber E, Salpeter EE. Coronary heart disease events associated with hormone therapy in younger and older women: a meta-analysis [brief report]. J Gen Intern Med. 2006;12:363–6.
Santoro N, Crawford SL, Lasley WL. Factors related to declining luteal function in women during the menopausal transition. J Clin Endocrinol Metab. 2008;93(5): 1711–21.
Saraç F, Saydam G, Sahin F, et al. Effects of hormone therapy replacement on insulin resistance and platelet function tests. Med Princ Pract. 2009;18:43–7.
Sherif K. The effects of hormone replacement therapy and oral contraceptive pills on blood pressure. Prog Cardiovasc Nurs 2000;15(1):21–23,28.
Sherwin BB, Henry JF. Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review. Front Neuroendocrinol. 2008;29:88–113.
Szmuilowicz ED, Adler GK, Ricchiuti V, et al. Relationships between endogenous sex hormone concentrations and vascular function in postmenopausal women [brief report]. J Clin Endocrinol Metab. 2007;92(12):4738–41.
Erel T, Guralp O. Epilepsy and menopause. Arch Gynecol Obstet. 2011;284(3):749–55.
Taylor HS, Manson JE. Update in hormone therapy use in menopause. J Clin Endocrinol Metab. 2011;96(2):255–64.
Tepper PG, Randolph Jr JF, McConnell DS, et al. Trajectory clustering of estradiol and follicle-stimulating hormone during the menopausal transition among women in the Study of Women’s Health across the nation (SWAN). Endocrine Res. 2012;97(8): 2872–80.
Thurston RC, Santoro N, Matthews KA. Adiposity and hot flashes in midlife women: a modifying role of age. J Clin Endocrinol Metab. 2011;96(10):E1588–95.
van de Weijer PHM. Risks of hormone therapy in the 50–59 year age group. Maturitas. 2008;60:59–64.
Wildman RP, Tepper PG, Crawford S, et al. Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from The Study of Women’s Health Across the Nation. J Clin Endocrinol Metab. 2012;97(9):E1695–704.
Women’s Health Initiative Investigators Writing Group. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288(3):321–33.
Xing D, Nozell S, Chen Y-F, et al. Estrogen and mechanisms of vascular protection. Arterioscler Thromb Vasc Biol. 2009;29:289–95.
Yamamoto H, Kitawaki J, Kikuchi N, et al. Effects of estrogens on cholinergic neurons in the rat basal nucleus. J Steroid Biochem Mol Biol. 2007;107:70–9.
Yang X-P, Reckelhoff JF. Estrogen, hormonal replacement therapy and cardiovascular disease. Curr Opin Nephrol Hypertens. 2011;20:133–8.
Zengin K, Tokac M, Akif Duzenli M, et al. Influence of menstrual cycle on cardiac performance. Maturitas. 2007;58:70–4.
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Sherif, K. (2013). FAQ: Definitions of Menopause and Biological Actions of Sex Steroids. In: Hormone Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6268-2_1
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DOI: https://doi.org/10.1007/978-1-4614-6268-2_1
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